GDC 0068 (Hydrochloride)
- Product Name
- GDC 0068 (Hydrochloride)
- CAS No.
- 1396257-94-5
- Chemical Name
- GDC 0068 (Hydrochloride)
- Synonyms
- GDC0068 2HCl;Ipatasertib 2HCl;RG-7440 dihydrochloride;GDC-0068 dihydrochloride;GDC 0068 (Hydrochloride);Ipatasertib (GDC-0068) 2HCl;Ipatasertib dihydrochloride;Ipatasertib dihydrochloride (GDC-0068);Ipatasertib (GDC-0068) dihydrochloride;Ipatasertib dihydrochloride, 10 mM in DMSO
- CBNumber
- CB22668572
- Molecular Formula
- C24H33Cl2N5O2
- Formula Weight
- 494.46
- MOL File
- 1396257-94-5.mol
GDC 0068 (Hydrochloride) Property
- storage temp.
- Store at -20°C, sealed storage, away from moisture
- solubility
- DMSO : 125 mg/mL (235.44 mM);Water : ≥ 41 mg/mL (77.22 mM)
- form
- Solid
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-4037
- Product name
- Ipatasertibdihydrochloride
- Purity
- 99.27%
- Packaging
- 2mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FC145493
- Product name
- Ipatasertib dihydrochloride
- Packaging
- 5mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-4037
- Product name
- Ipatasertibdihydrochloride
- Purity
- 99.27%
- Packaging
- 5mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- FC145493
- Product name
- Ipatasertib dihydrochloride
- Packaging
- 10mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-4037
- Product name
- Ipatasertibdihydrochloride
- Purity
- 99.27%
- Packaging
- 10mg
- Price
- $100
- Updated
- 2021/12/16
GDC 0068 (Hydrochloride) Chemical Properties,Usage,Production
Uses
Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective and ATP-competitive pan-Akt inhibitor with IC50s of 5, 18 and 8 nM for Akt1, Akt2 and Akt3, respectively.
in vivo
Ipatasertib is typically efficacious in xenograft models in which Akt is activated because of genetic alterations including PTEN loss, PIK3CA mutations/amplifications, or HER2 overexpression. In these models, tumor growth delay, stasis, or regression is achieved at or below 100 mg/kg daily oral dose, which is the maximum dose tested in immunocompromised mice that is well tolerated. When tested in vivo, daily dosing of Ipatasertib in combination with RP-56976 induces tumor regression and stasis in the PC-3 and MCF7-neo/HER2 xenograft models, at doses where each single agent is ineffective or only causes modest tumor growth delay. Similarly, increased TGI is observed in the OVCAR3 ovarian cancer xenograft model when Ipatasertib is combined with NSC 241240. The combination of Ipatasertib with RP-56976 or NSC 241240 is tolerated with less than 5% body weight loss when compared with treatment with each chemotherapeutic agent alone[2].
IC 50
Akt1: 5 nM (IC50); Akt3: 8 nM (IC50); Akt2: 18 nM (IC50); PKA: 3100 nM (IC50)
References
[1] Blake JF, et al. Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors. J Med Chem. 2012 Sep 27;55(18):8110-27. DOI:10.1021/jm301024w
[2] Lin J, et al. Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models. Clin Cancer Res. 2013 Apr 1;19(7):1760-72. DOI:10.1158/1078-0432.CCR-12-3072
GDC 0068 (Hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
GDC 0068 (Hydrochloride) Suppliers
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