5-broMo-3-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine
- Product Name
- 5-broMo-3-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine
- CAS No.
- 1150618-36-2
- Chemical Name
- 5-broMo-3-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine
- Synonyms
- 5-Bromo-3-(trifluoromethyl)-7-azaindole;5-broMo-3-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 5-bromo-3-(trifluoromethyl)-
- CBNumber
- CB22672957
- Molecular Formula
- C8H4BrF3N2
- Formula Weight
- 265.03
- MOL File
- 1150618-36-2.mol
5-broMo-3-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine Property
- Density
- 1.830±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 11.08±0.40(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PC201031
- Product name
- 5-Bromo-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $174
- Updated
- 2021/12/16
- Product number
- PC201031
- Product name
- 5-Bromo-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $277
- Updated
- 2021/12/16
- Product number
- 3H31-B-0F
- Product name
- 5-Bromo-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine
- Purity
- 95.0%
- Packaging
- 100mg
- Price
- $279
- Updated
- 2021/12/16
- Product number
- 3H31-B-0F
- Product name
- 5-Bromo-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine
- Purity
- 95.0%
- Packaging
- 250mg
- Price
- $444
- Updated
- 2021/12/16
- Product number
- HCH0295052
- Product name
- 5-BROMO-3-(TRIFLUOROMETHYL)-1H-PYRROLO[2,3-B]PYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.63
- Updated
- 2021/12/16
5-broMo-3-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine Chemical Properties,Usage,Production
Synthesis
892414-47-0
1150618-36-2
General procedure for the synthesis of 3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine from 3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine: Bromine (36.2 g, 0.2 mol) was added slowly and dropwise over a period of 1 h to dry dichloromethane (200 mL) that was cooled to -5°C. The reaction was followed by the addition of bromine (36.2 g, 0.2 mol). Subsequently, a solution of 3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine (25 g, 0.13 mol) and pyridine (17 mL) in dichloromethane (500 mL) was added dropwise. After dropwise addition, the reaction mixture was stirred at -5°C for 45 minutes. After completion of the reaction, the mixture was poured into a mixture of saturated aqueous sodium bicarbonate and sodium thiosulfate and extracted with ethyl acetate (3 x 1000 mL). The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate and subsequently concentrated to dryness under vacuum. The resulting residue was purified by recrystallization (ethyl acetate: petroleum ether = 8:1) to afford the target product 5-bromo-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine (7.55 g, 21% yield). The structure of the product was confirmed by NMR hydrogen spectroscopy (400 MHz, DMSO-d6): δ 12.76 (s, 1H), 8.44 (s, 1H), 8.23 (m, 2H).
References
[1] Patent: WO2014/111496, 2014, A1. Location in patent: Page/Page column 105; 106
[2] Patent: WO2016/142310, 2016, A1. Location in patent: Page/Page column 72
5-broMo-3-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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