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(4-BROMO-3-METHYLISOXAZOL-5-YL)METHYL ACETATE

Product Name
(4-BROMO-3-METHYLISOXAZOL-5-YL)METHYL ACETATE
CAS No.
1380089-33-7
Chemical Name
(4-BROMO-3-METHYLISOXAZOL-5-YL)METHYL ACETATE
Synonyms
(4-BROMO-3-METHYLISOXAZOL-5-YL)METHYL ACETATE;5-Isoxazolemethanol, 4-bromo-3-methyl-, 5-acetate
CBNumber
CB22676218
Molecular Formula
C7H8BrNO3
Formula Weight
234.05
MOL File
1380089-33-7.mol
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(4-BROMO-3-METHYLISOXAZOL-5-YL)METHYL ACETATE Property

Boiling point:
289.6±35.0 °C(Predicted)
Density 
1.552±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
-2.86±0.38(Predicted)
InChI
InChI=1S/C7H8BrNO3/c1-4-7(8)6(12-9-4)3-11-5(2)10/h3H2,1-2H3
InChIKey
USGKSLUGKUUZSM-UHFFFAOYSA-N
SMILES
C(OCC1ON=C(C)C=1Br)(=O)C
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific
Product number
OR46746
Product name
(4-Bromo-3-methylisoxazol-5-yl)methylacetate
Purity
97%
Packaging
1g
Price
$201
Updated
2021/12/16
Apolloscientific
Product number
OR46746
Product name
(4-Bromo-3-methylisoxazol-5-yl)methylacetate
Purity
97%
Packaging
250mg
Price
$87
Updated
2021/12/16
AK Scientific
Product number
2455AQ
Product name
4-BROMO-3-METHYLISOXAZOL-5-YL)METHYLACETATE
Packaging
5g
Price
$1257.2
Updated
2021/12/16
Ambeed
Product number
A262561
Product name
(4-Bromo-3-methylisoxazol-5-yl)methylacetate
Purity
97%
Packaging
250mg
Price
$51
Updated
2021/12/16
Ambeed
Product number
A262561
Product name
(4-Bromo-3-methylisoxazol-5-yl)methylacetate
Purity
97%
Packaging
1g
Price
$126
Updated
2021/12/16
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(4-BROMO-3-METHYLISOXAZOL-5-YL)METHYL ACETATE Chemical Properties,Usage,Production

Synthesis

43214-88-6

1380089-33-7

General procedure for the synthesis of (4-bromo-3-methylisoxazol-5-yl)methyl acetate from 3-methyl-5-isoxazolemethanol acetate: To a solution of (3-methylisoxazol-5-yl)methyl acetate (0.979 g, 6.31 mmol) in acetic acid (10 mL, 175 mmol) was added sequentially N-bromosuccinimide (1.30 g, 7.30 mmol) and sulfuric acid (0.65 mL, 12.19 mmol). The reaction mixture was heated to 110 °C and maintained for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and slowly poured into a beaker containing ice and saturated sodium bicarbonate solution. The two-phase mixture was vigorously stirred and the basic aqueous phase (pH 8-9) was subsequently extracted with ethyl acetate (2 x 15 mL). The organic phase was washed sequentially with 2% sodium thiosulfate solution and brine (20 mL), dried over anhydrous sodium sulfate and concentrated to give a light yellow oil. The crude product was purified by a Biotage purification system (isocratic elution, 10% ethyl acetate: 90% hexane) to afford the title compound (4-bromo-3-methylisoxazol-5-yl)methyl acetate (1.30 g, 5.55 mmol, 88% yield) as a colorless to light yellow oil. lc/ms m/z 234 [M + H]+.

References

[1] Patent: WO2012/75383, 2012, A2. Location in patent: Page/Page column 82
[2] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 9, p. 835 - 840
[3] Patent: WO2013/184878, 2013, A1. Location in patent: Paragraph 00241; 00242
[4] Patent: WO2013/184876, 2013, A1. Location in patent: Paragraph 00144; 00147; 00148
[5] Patent: WO2016/97870, 2016, A1. Location in patent: Paragraph 0168

(4-BROMO-3-METHYLISOXAZOL-5-YL)METHYL ACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-BROMO-3-METHYLISOXAZOL-5-YL)METHYL ACETATE Suppliers

China 40 India 1 United States 2 Global 43
Beijing Yisiyan Technology Research Center
Tel
010-56645598 13366904824
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01062230033
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bjkaida@163.com
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China
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Beijing Ouhe Technology Co., Ltd
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010-010-82967028 13522913783
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+86-10-82967029
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2355560935@qq.com
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China
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skychemical Co.Ltd
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021-20958197 20965099
Fax
021-20960837
Email
sales@skychemical.com
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China
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Shanghai Hope Chem Co., Ltd.，
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+21-18501659228 18501659228
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sales@hope-chem.com
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info@hope-chem.com
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China
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Shanghai Jian Chao Chemical Technology Co., Ltd.
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150-2103-5486 18017383231
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qq：2817624287
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983544897@qq.com
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China
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Aloespharm Co., Ltd.
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021-20960837
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021-20960837
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market@aloespharm.com
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China
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ShangHai Angti Biotechnology Co., Ltd.
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13764913901
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info@angtibio.com
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China
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skychemical Co.Ltd
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021-20960837,QQ1332204249
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021-20960837
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sales@skychemical.com
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China
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3341
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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China
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8000
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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China
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View Lastest Price from (4-BROMO-3-METHYLISOXAZOL-5-YL)METHYL ACETATE manufacturers

Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
Product
(4-BROMO-3-METHYLISOXAZOL-5-YL)METHYL ACETATE 1380089-33-7
Price
US $0.00-0.00/kg
Min. Order
0.1kg
Purity
98%
Supply Ability
100kg
Release date
2023-03-09
Career Henan Chemical Co
Product
(4-BROMO-3-METHYLISOXAZOL-5-YL)METHYL ACETATE 1380089-33-7
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2019-08-07

1380089-33-7, (4-BROMO-3-METHYLISOXAZOL-5-YL)METHYL ACETATERelated Search:


  • (4-BROMO-3-METHYLISOXAZOL-5-YL)METHYL ACETATE
  • 5-Isoxazolemethanol, 4-bromo-3-methyl-, 5-acetate
  • 1380089-33-7