GGTI 298 trifluoroacetate salt hydrate

Product Name: GGTI 298 trifluoroacetate salt hydrate
CAS No.: 1217457-86-7
Chemical Name: GGTI 298 trifluoroacetate salt hydrate
Synonyms: GGTI-298 TFA;GGTI 298 TFA salt;GGTI298 Trifluoroacetate;WALKWJPZELDSKT-UFABNHQSSA-N;GGTI 298 trifluoroacetate salt hydrate;GGTI 298 TFA SALT;GGTI 298 (TRIFLUOROACETATE SALT);N-[[4-(2-(R)-Amino-3-mercaptopropyl)amino]-2-naphthylbenzoyl]leucine methyl ester trifluoroacetate salt hydrate;(S)-Methyl 2-(4-(((R)-2-amino-3-mercaptopropyl)amino)-2-(naphthalen-1-yl)benzamido)-4-methylpentanoate 2,2,2-trifluoroacetate
CBNumber: CB22676894
Molecular Formula: C29H34F3N3O5S
Formula Weight: 593.66
MOL File: 1217457-86-7.mol

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GGTI 298 trifluoroacetate salt hydrate Property

Melting point:: 99.5-100°C
storage temp.: -20°C
solubility: DMSO: >20mg/mL
form: film &_& lyophilized
color: colorless

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G5169
Product name: GGTI 298 trifluoroacetate salt hydrate
Purity: ≥90% (HPLC), film
Packaging: 250μg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: G5169
Product name: GGTI 298 trifluoroacetate salt hydrate
Purity: ≥90% (HPLC), film
Packaging: 1mg
Price: $440
Updated: 2024/03/01

Cayman Chemical

Product number: 16176
Product name: GGTI 298 (trifluoroacetate salt)
Purity: ≥95%
Packaging: 500μg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 16176
Product name: GGTI 298 (trifluoroacetate salt)
Purity: ≥95%
Packaging: 1mg
Price: $184
Updated: 2024/03/01

Cayman Chemical

Product number: 16176
Product name: GGTI 298 (trifluoroacetate salt)
Purity: ≥95%
Packaging: 5mg
Price: $816
Updated: 2024/03/01

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GGTI 298 trifluoroacetate salt hydrate Chemical Properties,Usage,Production

Uses

GGTI 298 trifluoroacetate salt hydrate has been used as a geranylgeranyltransferase I (GGTase I) inhibitor:

to study the anticancer effects of statins along with GGTI 298
to study its combinatorial effects with FTI-277 on statin-mediated activation of extracellular signal-regulated kinase 5 (ERK5) in the human endothelium
to evaluate the effect of protein geranylgeranylation (GG) inhibition on the breast cancer stem cell (CSC) population

Biochem/physiol Actions

GGTI 298 is a cell-permeable, prodrug form of the geranylgeranyltransferase I (GGTase I) inhibitor GGTI-297. It inhibits the processing of Rap 1A without effecting the processing of H-Ras.

storage

Store at -20°C

GGTI 298 trifluoroacetate salt hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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GGTI 298 trifluoroacetate salt hydrate Suppliers

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1217457-86-7, GGTI 298 trifluoroacetate salt hydrateRelated Search:

Silver

GGTI 298 trifluoroacetate salt hydrate

N-[[4-(2-(R)-Amino-3-mercaptopropyl)amino]-2-naphthylbenzoyl]leucine methyl ester trifluoroacetate salt hydrate

GGTI-298 TFA

GGTI298 Trifluoroacetate

WALKWJPZELDSKT-UFABNHQSSA-N

GGTI 298 TFA salt

GGTI 298 TFA SALT;GGTI 298 (TRIFLUOROACETATE SALT)

(S)-Methyl 2-(4-(((R)-2-amino-3-mercaptopropyl)amino)-2-(naphthalen-1-yl)benzamido)-4-methylpentanoate 2,2,2-trifluoroacetate

1217457-86-7