ZENIPLATIN
- Product Name
- ZENIPLATIN
- CAS No.
- 111490-36-9
- Chemical Name
- ZENIPLATIN
- Synonyms
- ZENIPLATIN;Zeniplatinum;ZENIPLATIN USP/EP/BP;(sp-4-2)-[2，2-Bis(aminc~nethyl)-1，3-propanediol-N，N，][1，1-cyclobutanedicarboxylato(2-)-O，O’]platinum
- CBNumber
- CB2267690
- Molecular Formula
- C11H20N2O6Pt
- Formula Weight
- 471.36
- MOL File
- 111490-36-9.mol
ZENIPLATIN Property
- Melting point:
- 210-212 °C
N-Bromosuccinimide Price
- Product number
- API0012816
- Product name
- ZENIPLATIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.98
- Updated
- 2021/12/16
ZENIPLATIN Chemical Properties,Usage,Production
Originator
Zeniplatin,American Cyanamid (AHP)
Uses
Antineoplastic.
Manufacturing Process
The compound of 2,2-dibromomethyl-1,3-propanediol was prepared by the
method M. Saivier (et al.), Can. J. Chem; 44, 1599 (1966).
A mixture of 13.1 g of 2,2-dibromomethyl-1,3-propanediol, 6.5 g of sodium
azide and 750 ml of dimethylformamide was stirred and heated at 110°-
120°C for 20 h, then clarified and the filtrate evaporated. The residue was
extracted three times with dichloromethane. The extracts were combined and
evaporated, giving 13.65 g of 2,2-bis(azidomethyl)-1,3-propanediol,
compound with dimethylformamide.
A 13.0 g portion of the 2,2-bis(azidomethyl)-1,3-propanediol was reduced
with 0.1 g of platinum dioxide in ethanol, using 50 lb of hydrogen pressure for
20 h. The mixture was then filtered and the filtrate concentrated to dryness,
giving 9.34 g of 2,2-bis(aminomethyl)-1,3-propanediol as a pale yellow oil.
A mixture of 1.34 g of 2,2-bis(aminomethyl)-1,3-propanediol, 4.15 g of
potassium dichloroplatinate and 22 ml of water was stirred for 2 h, then
cooled, the solid collected and washed three times with cold water. This solid
was recrystallized from 60 ml of hot water, giving 890.0 mg of the desired
[2,2-bis(aminomethyl)-1,3-propanediol-N,N']dichloroplatinum as beige
crystals, melting point 223°-225°C (dec.).
A mixture of 0.8 g of [2,2-bis(aminomethyl)-1,3-propanediol-
N,N']dichloroplatinum and 0.78 g of the disilver salt of 1,1-cyclobutane
dicarboxylic acid in 50 ml of water was stirred in the dark overnight and then
filtered. The filtrate was evaporated to dryness, giving 0.72 g of the desired
[2,2-bis(aminomethyl)-1,3-propanediol-N,N'][[1,1'-
cyclobutanedicarboxylato](2-)-O1,O1]platinum as a beige powder, melting
point 202°-205°C (dec.).
Therapeutic Function
Antineoplastic
ZENIPLATIN Preparation Products And Raw materials
Raw materials
Preparation Products
ZENIPLATIN Suppliers
- Tel
- 1-(800)-881-8210
- Fax
- 615-250-9817
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- United States
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- +1-781-999-5354 +1-00000000000
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- China
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- China
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- 021-61734564
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- China
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View Lastest Price from ZENIPLATIN manufacturers
- Product
- ZENIPLATIN 111490-36-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-02