Ro 25-6981 (Maleate)

Product Name: Ro 25-6981 (Maleate)
CAS No.: 1312991-76-6
Chemical Name: Ro 25-6981 (Maleate)
Synonyms: Ro 25-6981 maleate salt, NR2B antagonist;Ro 25-6981 maleate salt (mM/ml), NR2B antagonist;[R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate salt;1-Piperidinepropanol, α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-, ( αR,βS)-, (2Z)-2-butenedioate (1:1)
CBNumber: CB22677053
Molecular Formula: C26H33NO6
Formula Weight: 455.55
MOL File: 1312991-76-6.mol

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Ro 25-6981 (Maleate) Property

storage temp.: 2-8°C
solubility: H2O: soluble2mg/mL (clear solution, warmed)
form: powder
color: white to beige
optical activity: [α]/D +15 to +22°, c = 1 in methanol
Water Solubility: H2O: 2mg/mL (clear solution, warmed)

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Safety

Hazard Codes: Xi,N
Risk Statements: 36/37/38-50
Safety Statements: 26-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H400Very toxic to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0495
Product name: Ro 25-6981 maleate salt
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $159
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0495
Product name: Ro 25-6981 maleate salt
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $507
Updated: 2024/03/01

Cayman Chemical

Product number: 14578
Product name: Ro 25-6981 (maleate)
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 14578
Product name: Ro 25-6981 (maleate)
Purity: ≥98%
Packaging: 10mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 14578
Product name: Ro 25-6981 (maleate)
Purity: ≥98%
Packaging: 50mg
Price: $820
Updated: 2024/03/01

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Ro 25-6981 (Maleate) Chemical Properties,Usage,Production

Uses

Ro 25-6981 maleate is a potent NMDA receptor antagonist.

Definition

ChEBI: Ro 25-6981 maleate is the maleic acid salt of Ro 25-6981. It is a potent and selective antagonist of GluN2B-containing NMDA receptors. It has a role as an anticonvulsant, an antidepressant, a neuroprotective agent and a NMDA receptor antagonist. It contains a Ro 25-6981(1+).

Biochem/physiol Actions

Ro 25-6981 maleate salt is a potent and selective antagonist of NMDA glutamate receptors containing the NR2B subunit with IC50 values of .009 μM for NR2B vs. 52 μM for NR2A subunits. Ro 25-6981 has been shown to have neuroprotectant effects and to reduce inflammatory and neuropathic pain in rodent models.

storage

Room temperature (desiccate)

Ro 25-6981 (Maleate) Preparation Products And Raw materials

Raw materials

Preparation Products

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Ro 25-6981 (Maleate) Suppliers

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1312991-76-6, Ro 25-6981 (Maleate)Related Search:

[R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate salt

1-Piperidinepropanol, α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-, ( αR,βS)-, (2Z)-2-butenedioate (1:1)

Ro 25-6981 maleate salt, NR2B antagonist

Ro 25-6981 maleate salt (mM/ml), NR2B antagonist

1312991-76-6

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