N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE

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N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE

Product Name: N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE
CAS No.: 31750-48-8
Chemical Name: N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE
Synonyms: ici55,548;desmethyltamoxifen;n-desmethyltamoxifen;Tamoxifen EP Impurity F;N-DESMETHYL TAMOXIFEN HCL;tamoxifen citrate impurity F;N-DEMETHYLTAMOXIFEN, HYDROCHLORIDE;N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE;2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(p-((z)-ethylamin;2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(4-((z)-ethanamin
CBNumber: CB2267847
Molecular Formula: C25H27NO
Formula Weight: 357.49
MOL File: 31750-48-8.mol

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N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE Property

Boiling point:: 485.8±33.0 °C(Predicted)
Density: 1.047±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 72 mg/mL (201.40 mM);Ethanol: 36 mg/mL (100.70 mM)
pka: 9.38±0.10(Predicted)
Water Solubility: Water: Insoluble

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H350May cause cancer

H360May damage fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P314Get medical advice/attention if you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Usbiological

Product number: D3220-90M
Product name: N-Desmethyltamoxifen, Hydrochloride
Packaging: 5mg
Price: $460
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 34558
Product name: N-Desmethyltamoxifen HCl
Packaging: 5mg
Price: $1440
Updated: 2021/12/16

Acrotein

Product number: DM-3492
Product name: 2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N-methylethanamineHCl
Purity: 97%
Packaging: 1g
Price: $220
Updated: 2021/12/16

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N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE Chemical Properties,Usage,Production

Definition

ChEBI: N-Desmethyltamoxifen is a stilbenoid.

Biological Activity

N-Desmethyltamoxifen is the main metabolite of Tamoxifen in the human body. N-Desmethyltamoxifen, a weaker antiestrogen, is a protein kinase C (PKC) inhibitor ten times stronger than Tamoxifen. It is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis and sphingosine phosphorylation.

in vitro

N-desmethyltamoxifen (20-500 ng/ml; 48 hours) has a profound inhibitory effect upon all seven glioma lines (T98G, U87, U138, U373, ALW, AUK, CAS cells).
It inhibits growth of MCF 7 human mammary carcinoma cells.
N-desmethyltamoxifen, resulting from the CYP3A4/5-mediated catalysis of tamoxifen, is the major primary quantitative metabolite of tamoxifen.

Cell Viability Assay

td>

Cell Line:	MCF 7 human mammary carcinoma cells
Concentration:	1.5, 2.5, 5, 7.5, 10 μM
Incubation Time:	114 hours
Result:	Inhibits growth of MCF 7 human mammary carcinoma cells

target

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N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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31750-48-8, N-DESMETHYLTAMOXIFEN, HYDROCHLORIDERelated Search:

Tamoxifen

(Z)-2-[4-(1,2-DIPHENYL-1-BUTENYL)PHENOXY]-N-METHYL-ETHANAMINE

Tamoxifen EP Impurity F

2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N-methylethanamine HCl

N-DESMETHYL TAMOXIFEN HCL

N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE

N-DEMETHYLTAMOXIFEN, HYDROCHLORIDE

2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(4-((z)-ethanamin

2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(p-((z)-ethylamin

cis-2-(p-(1,2-diphenyl-1-butenyl)phenoxy)-n-methylethylamine

desmethyltamoxifen

ici55,548

n-desmethyltamoxifen

Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N-methyl-

(Z)-2-(4-(1,2-diphenylbut-1-en-1-yl)phenoxy)-N-methylethanamine

tamoxifen citrate impurity F

2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N-methyl-ethanamine

31750-48-8

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PKC	Estrogen Receptor