LenalidoMide (heMihydrate)

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LenalidoMide (heMihydrate)

Product Name: LenalidoMide (heMihydrate)
CAS No.: 847871-99-2
Chemical Name: LenalidoMide (heMihydrate)
Synonyms: Lenalidonmide;CC-5013 hemihydrate;LenalidoMide (heMihydrate);Lenalidomide hemihydrate (Revlimid, CC 5013);3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione hemihydrate;IKZF3,inhibit,IKZF1,ligand,Inhibitor,CC-5013 hemihydrate,degradation,myeloma,Ligands for E3 Ligase,analog,multiple,Lenalidomide hemihydrate,immunomodulatory,E3 ligase-recruiting Moiety,CRL4,ligase,Molecular Glues,cereblon,Apoptosis
CBNumber: CB22682011
Molecular Formula: C26H28N6O7
Formula Weight: 536.53652
MOL File: 847871-99-2.mol

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LenalidoMide (heMihydrate) Property

storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (186.38 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form: Powder
color: Off-white to pink
InChI: InChI=1S/2C13H13N3O3.H2O/c2*14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18;/h2*1-3,10H,4-6,14H2,(H,15,17,18);1H2
InChIKey: OTJHSDXKMBRCMM-UHFFFAOYSA-N

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B1188
Product name: Lenalidomidehemihydrate
Packaging: 50mg
Price: $113
Updated: 2021/12/16

ApexBio Technology

Product number: B1188
Product name: Lenalidomidehemihydrate
Packaging: 100mg
Price: $180
Updated: 2021/12/16

ApexBio Technology

Product number: B1188
Product name: Lenalidomidehemihydrate
Packaging: 500mg
Price: $300
Updated: 2021/12/16

ApexBio Technology

Product number: B1188
Product name: Lenalidomidehemihydrate
Packaging: 1g
Price: $465
Updated: 2021/12/16

Crysdot

Product number: CD31000637
Product name: Lenalidomidehemihydrate
Purity: 98+%
Packaging: 50mg
Price: $53
Updated: 2021/12/16

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LenalidoMide (heMihydrate) Chemical Properties,Usage,Production

Biological Activity

LenalidoMide (heMihydrate) is a derivative of Thalidomide and an orally active immunomodulator. It is a ligand for the ubiquitin E3 ligase cereblon (CRBN), selectively ubiquitinates and degrades two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. It specifically inhibits the growth of mature B-cell lymphomas, including multiple myeloma, and induces the release of interleukin-2 (IL-2) from T cells.

in vitro

LenalidoMide (heMihydrate) is potent in stimulating T cell proliferation and IFN-γ and IL-2 production. It has been shown to inhibit production of pro inflammatory cytokines TNF-α, IL-1, IL-6, IL-12 and elevate the production of anti-inflammatory cytokine IL-10 from human PBMCs. It downregulates the production of IL-6 directly and also by inhibiting multiple myeloma (MM) cells and bone marrow stromal cells (BMSC) interaction, which augments the apoptosis of myeloma cells. Dose-dependent interaction with the CRBN-DDB1 complex is observed with Thalidomide, Lenalidomide and Pomalidomide, with IC ₅₀ values of ~30 μM, ~3 μM and ~3 μM, respectively, These reduced CRBN expression cells (U266-CRBN ₆₀ and U266-CRBN ₇₅ ) are less responsive than the parental cells to antiproliferative effects Lenalidomide across a dose-response range of 0.01 to 10 μM . Lenalidomide, a thalidomide analog, functions as a molecular glue between the human E3 ubiq uitin ligase cereblon and CKIα is shown to induce the ubiquitination and degradation of this kinase, thus presumably killing leukemic cells by p53 activation.

in vivo

The toxicity of LenalidoMide (heMihydrate) doses up to 15, 22.5, and 45 mg/kg via IV, IP, and PO routes of administration. Limited by solubility in our PBS dosing vehicle, these maximum achievable Lenalidomide doses are well tolerated with the exception of one mouse death (of four total dosed) at the 15 mg/kg IV dose. Notably, no other toxicities are observed in the study at IV doses of 15 mg/kg (n=3) or 10 mg/kg (n=45) or at any other dose level through IV, IP, and PO routes.

target

Cereblon

LenalidoMide (heMihydrate) Preparation Products And Raw materials

Raw materials

Preparation Products

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847871-99-2, LenalidoMide (heMihydrate)Related Search:

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Lenalidonmide

IKZF3,inhibit,IKZF1,ligand,Inhibitor,CC-5013 hemihydrate,degradation,myeloma,Ligands for E3 Ligase,analog,multiple,Lenalidomide hemihydrate,immunomodulatory,E3 ligase-recruiting Moiety,CRL4,ligase,Molecular Glues,cereblon,Apoptosis

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2C13H13N3O3H2O