Ethyl8-hydroxy-2-MethyliMidazo[1,2-a]pyridine-3-carboxylate

Product Name: Ethyl8-hydroxy-2-MethyliMidazo[1,2-a]pyridine-3-carboxylate
CAS No.: 173530-73-9
Chemical Name: Ethyl8-hydroxy-2-MethyliMidazo[1,2-a]pyridine-3-carboxylate
Synonyms: Ethyl8-hydroxy-2-MethyliMidazo[1,2-a]pyridine-3-carboxylate;8-Hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester;Imidazo[1,2-a]pyridine-3-carboxylic acid, 8-hydroxy-2-methyl-, ethyl ester
CBNumber: CB22682233
Molecular Formula: C11H12N2O3
Formula Weight: 220.22
MOL File: 173530-73-9.mol

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Ethyl8-hydroxy-2-MethyliMidazo[1,2-a]pyridine-3-carboxylate Property

Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 4.90±0.30(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: E946060
Product name: Ethyl8-Hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxylate
Packaging: 50mg
Price: $90
Updated: 2021/12/16

AK Scientific

Product number: 6804AJ
Product name: Ethyl8-hydroxy-2-methylimidazo[1,2-A]pyridine-3-carboxylate
Packaging: 5g
Price: $1204
Updated: 2021/12/16

Ambeed

Product number: A115126
Product name: Ethyl8-hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxylate
Purity: 97%
Packaging: 100mg
Price: $78
Updated: 2021/12/16

Ambeed

Product number: A115126
Product name: Ethyl8-hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxylate
Purity: 97%
Packaging: 250mg
Price: $119
Updated: 2021/12/16

Chemenu

Product number: CM133629
Product name: ethyl8-hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxylate
Purity: 95+%
Packaging: 250mg
Price: $190
Updated: 2021/12/16

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Ethyl8-hydroxy-2-MethyliMidazo[1,2-a]pyridine-3-carboxylate Chemical Properties,Usage,Production

Synthesis

96428-50-1

173530-73-9

Example 3A Synthesis of ethyl 8-hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxylate: 31.45 g (101.3 mmol) of ethyl 8-(benzyloxy)-2-methylimidazo[1,2-a]pyridine-3-carboxylate was dissolved in 2 L of ethyl acetate and 3.15 g of 10% Pd/C catalyst was added. The mixture was stirred at room temperature and atmospheric pressure for 5 hours in a hydrogen atmosphere. Upon completion of the reaction, the mixture was filtered through diatomaceous earth and the filter cake was washed well with ethyl acetate/methanol (volume ratio not specified). The filtrates were combined and concentrated to dryness under reduced pressure to give 21.94 g ethyl 8-hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxylate in 98% yield and 99% purity. The product was analyzed by LC-MS (Method 1): retention time (Rt) = 0.61 min, mass spectrum (ESpos): m/z = 221 [M + H]+. 1H NMR (400 MHz, DMSO-d6) δ: 1.36 (t, 3H), 2.60 (s, 3H), 4.36 (q, 2H), 6.78 (d, 1H), 6.98 (t , 1H), 8.73 (d, 1H), 10.60 (br s, 1H).

References

[1] Patent: US2014/128386, 2014, A1. Location in patent: Paragraph 0994; 0995; 0996; 0997; 0997
[2] Patent: US2017/57954, 2017, A1. Location in patent: Paragraph 0625; 0626; 0627; 0628; 0629
[3] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999, vol. 38, # 6, p. 635 - 638
[4] Patent: US2017/217954, 2017, A1

Ethyl8-hydroxy-2-MethyliMidazo[1,2-a]pyridine-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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173530-73-9, Ethyl8-hydroxy-2-MethyliMidazo[1,2-a]pyridine-3-carboxylateRelated Search:

8-(trifluoroMethyl)isoquinolin-3-ol 8-HYDROXY-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE IMidazo[1,2-a]pyridine-2-carboxylic acid, 8-hydroxy-, ethyl ester 8-(trifluoroMethyl)isoquinolin-3-aMine 2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-ol 8-Trifluoromethylquinoline 8-Isoquinolinecarbonitrile(9CI) 8-Isoquinolinol 8-Hydroxyimidazo[1,2-a]pyridine-3-carbaldehyde 8-CYANO-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER Imidazo[1,2-a]pyrazin-8(7H)-one (9CI)

8-Hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester

Ethyl8-hydroxy-2-MethyliMidazo[1,2-a]pyridine-3-carboxylate

Imidazo[1,2-a]pyridine-3-carboxylic acid, 8-hydroxy-2-methyl-, ethyl ester

173530-73-9