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(S)-b-AMino-4-chloro-benzeneethanol

Product Name
(S)-b-AMino-4-chloro-benzeneethanol
CAS No.
191109-51-0
Chemical Name
(S)-b-AMino-4-chloro-benzeneethanol
Synonyms
(S)-b-AMino-4-chloro-benzeneethanol;(S)-2-aMino-2-(4-chlorophenyl)ethanol;(2S)-2-Amino-2-(4-chlorophenyl)ethanol;(S)-2-Amino-2-(4-chlorophenyl)ethan-1-ol;Benzeneethanol, β-amino-4-chloro-, (βS)-;(2S)-2-AMINO-2-(4-CHLOROPHENYL)ETHAN-1-OL;(S)-1-(4-chlorophenyl)-2-hydroxyethylamine;(S)-2-Amino-2-(4-chlorophenyl)ethan-1-ol - [A91747]
CBNumber
CB22684222
Molecular Formula
C8H10ClNO
Formula Weight
171.6241
MOL File
191109-51-0.mol
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(S)-b-AMino-4-chloro-benzeneethanol Property

Boiling point:
319.8±27.0 °C(Predicted)
Density 
1.260±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
12.43±0.10(Predicted)
Appearance
White to off-white Solid
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Safety

HS Code 
2922190090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A621218
Product name
(S)-2-Amino-2-(4-chlorophenyl)ethanolhydrochloride
Packaging
5mg
Price
$65
Updated
2021/12/16
TRC
Product number
A621218
Product name
(S)-2-Amino-2-(4-chlorophenyl)ethanolhydrochloride
Packaging
10mg
Price
$90
Updated
2021/12/16
ChemScene
Product number
CS-0037479
Product name
(S)-2-Amino-2-(4-chlorophenyl)ethan-1-ol
Packaging
100mg
Price
$131
Updated
2021/12/16
Apolloscientific
Product number
OR452154
Product name
(S)-b-Amino-4-chloro-benzeneethanol
Purity
97%
Packaging
250mg
Price
$348
Updated
2021/12/16
ChemScene
Product number
CS-0037479
Product name
(S)-2-Amino-2-(4-chlorophenyl)ethan-1-ol
Packaging
1g
Price
$436
Updated
2021/12/16
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(S)-b-AMino-4-chloro-benzeneethanol Chemical Properties,Usage,Production

Synthesis

67336-19-0

191109-51-0

The general procedure for the synthesis of (S)-2-amino-2-(4-chlorophenyl)ethanol from (S)-4-chlorophenylglycine was as follows: to a solution of (S)-2-amino-2-(4-chlorophenyl)acetic acid (10.0 g, 53.9 mmol) in tetrahydrofuran (THF, 216 mL) was slowly added dropwise to a solution of (S)-2-amino-2-(4-chlorophenyl)acetic acid (10.0 g, 53.9 mmol) in the presence of a 1.0 M borane tetrahydrofuran complex (216 mL. 216 mmol) over 45 min. After removal of the ice bath, the reaction mixture was continued to be stirred at room temperature for 3.25 hours. Subsequently, water (6.79 mL, 377 mmol) was slowly added followed by sodium hydroxide solution (40.4 mL, 202 mmol) dropwise over 15 minutes. The reaction mixture was heated to 65 °C and stirred at this temperature for 18 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure. The residue was dissolved in dichloromethane (DCM, 500 mL), the organic phase was separated and washed with deionized water (200 mL). The aqueous phase was further extracted with dichloromethane (2 x 250 mL). All organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to afford (S)-2-amino-2-(4-chlorophenyl)ethanol as a white solid (8.55 g, 92% yield). The product was characterized by LC-MS and 1H NMR: the calculated exact mass (C8H10ClNO) was 171.1, and the measured LC-MS m/z (%) was 172.2 ([M+H]+, 35Cl, 100) and 174.2 ([M+H]+, 37Cl, 33); 1H NMR (400 MHz, methanol-d4) δ ppm 3.47- 3.57 (m, 1H), 3.59-3.69 (m, 1H), 3.93 (dd, J=7.58,5.05Hz, 1H), 7.23-7.42 (m, 4H).

References

[1] Patent: WO2009/58300, 2009, A1. Location in patent: Page/Page column 53-54

(S)-b-AMino-4-chloro-benzeneethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-b-AMino-4-chloro-benzeneethanol Suppliers

China 40 Global 40
Tetranov Biopharm
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13526569071
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China
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Shanghai Hanhong Scientific Co.,Ltd.
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Amatek Scientific Co. Ltd.
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Bide Pharmatech Ltd.
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LABTER PHARMATECH(BEIJING) CO.,LTD
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Chongqing Acemol Technology Co.,Ltd
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Shanghai YuanYe Biotechnology Co., Ltd.
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Amadis Chemical Company Limited
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571-89925085
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Shanghai CR Corporation Limited
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191109-51-0, (S)-b-AMino-4-chloro-benzeneethanolRelated Search:

Ethanol

  • (S)-b-AMino-4-chloro-benzeneethanol
  • (S)-2-aMino-2-(4-chlorophenyl)ethanol
  • (2S)-2-AMINO-2-(4-CHLOROPHENYL)ETHAN-1-OL
  • (2S)-2-Amino-2-(4-chlorophenyl)ethanol
  • (S)-2-Amino-2-(4-chlorophenyl)ethan-1-ol
  • (S)-1-(4-chlorophenyl)-2-hydroxyethylamine
  • Benzeneethanol, β-amino-4-chloro-, (βS)-
  • (S)-2-Amino-2-(4-chlorophenyl)ethan-1-ol - [A91747]
  • 191109-51-0