Kif15-IN-1
- Product Name
- Kif15-IN-1
- CAS No.
- 672926-32-8
- Chemical Name
- Kif15-IN-1
- Synonyms
- Kif15-IN-1;Kif15 inhibitor 1;Kif-15-IN-1,Kif15IN1,Kif15 IN 1;Ethyl (S)-2-(2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-3-methylbutanamido)-4-methylthiazole-5-carboxylate;2-[[(2S)-2-(1,4-Dihydro-2,4-dioxo-3(2H)-quinazolinyl)-3-methyl-1-oxobutyl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester;5-Thiazolecarboxylic acid, 2-[[(2S)-2-(1,4-dihydro-2,4-dioxo-3(2H)-quinazolinyl)-3-methyl-1-oxobutyl]amino]-4-methyl-, ethyl ester
- CBNumber
- CB22685926
- Molecular Formula
- C20H22N4O5S
- Formula Weight
- 430.48
- MOL File
- 672926-32-8.mol
Kif15-IN-1 Property
- Density
- 1.361±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; insoluble in DMSO; ≥19.2 mg/mL in EtOH
- form
- Solid
- pka
- 7.73±0.50(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- B3280
- Product name
- Kif15-IN-1
- Packaging
- 2mg
- Price
- $341
- Updated
- 2021/12/16
- Product number
- CS-2697
- Product name
- Kif15-IN-1
- Purity
- 99.53%
- Packaging
- 5mg
- Price
- $420
- Updated
- 2021/12/16
- Product number
- B3280
- Product name
- Kif15-IN-1
- Packaging
- 5mg
- Price
- $513
- Updated
- 2021/12/16
- Product number
- CS-2697
- Product name
- Kif15-IN-1
- Purity
- 99.53%
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
- Product number
- B3280
- Product name
- Kif15-IN-1
- Packaging
- 10mg
- Price
- $733
- Updated
- 2021/12/16
Kif15-IN-1 Chemical Properties,Usage,Production
Uses
Kif15-IN-1 is an inhibitor of the mitotic Kinesin family member 15 (Kif15), and is used for the research of cellular proliferative diseases.
Biological Activity
kif15-in-1, a potent kif15 kinesin inhibitor; inhibits cellular proliferation in various tumor cell lines [1].kif15,also known as kinesin-12 and hklp2, is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth [2]. kif15 is a kinesin-related protein whose mitotic homologues are believed to crosslink and immobilize spindle microtubules.kif15 is involved in maintaining bipolar microtubulespindle apparatusin dividing cells and shares redundant functions with kif11 [3].
IC 50
KIF15
References
[1]. preparation of quinazolinediones as kif15 kinesin inhibitors for treating cellular proliferative disorders. pat. appl. publ. (2004), us 20040053948 a1 20040318.
[2]. buster d w, baird d h, yu w, et al. expression of the mitotic kinesin kif15 in postmitotic neurons: implications for neuronal migration and development[j]. journal of neurocytology, 2003, 32(1): 79-96.
[3]. vanneste d, takagi m, imamoto n, et al. the role of hklp2 in the stabilization and maintenance of spindle bipolarity[j]. current biology, 2009, 19(20): 1712-1717.
Kif15-IN-1 Preparation Products And Raw materials
Raw materials
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