ChemicalBook > CAS DataBase List > OMadacycline (tosylate)

OMadacycline (tosylate)

Product Name
OMadacycline (tosylate)
CAS No.
1075240-43-5
Chemical Name
OMadacycline (tosylate)
Synonyms
QTH11;Omycycline;Omacycline Mesylate;Tyrosine Impurity 22;Omadacyeline tosylate;Omadacycline tosylater;OMadacycline (tosylate);Omacycline p-toluene sulfonate;Omadacycline p-Toluenesulfonate;Omachycline p-toluene sulfonate
CBNumber
CB22685931
Molecular Formula
C36H48N4O10S
Formula Weight
728.86
MOL File
1075240-43-5.mol
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OMadacycline (tosylate) Property

storage temp. 
4°C, protect from light
solubility 
Soluble in DMSO
InChIKey
SETFNHZTVGTBHC-MPRIKUDSNA-N
SMILES
S(C1C=CC(C)=CC=1)(O)(=O)=O.O[C@@]12C(C(C(=O)N)=C(O)[C@@H](N(C)C)[C@]1([H])C[C@]1([H])CC3=C(C=C(CNCC(C)(C)C)C(O)=C3C(=O)C1=C2O)N(C)C)=O |&1:12,20,24,27,r|
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-2465
Product name
Omadacycline(tosylate)
Purity
99.37%
Packaging
50mg
Price
$1800
Updated
2021/12/16
ChemScene
Product number
CS-2465
Product name
Omadacycline(tosylate)
Purity
99.37%
Packaging
5mg
Price
$312
Updated
2021/12/16
ChemScene
Product number
CS-2465
Product name
Omadacycline(tosylate)
Purity
99.37%
Packaging
10mg
Price
$540
Updated
2021/12/16
Crysdot
Product number
CD31004645
Product name
Omadacyclinetosylate
Purity
98+%
Packaging
50mg
Price
$631
Updated
2021/12/16
Crysdot
Product number
CD31004645
Product name
Omadacyclinetosylate
Purity
98+%
Packaging
5mg
Price
$182
Updated
2021/12/16
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OMadacycline (tosylate) Chemical Properties,Usage,Production

Description

Omadacycline tosylate is a semisynthetic tetracycline-class antibacterial agent, which has been designated by some as a “new-generation tetracycline” or “the first in a new class of aminomethylcyclines.” Omadacycline has been structurally modified to provide effectiveness against certain strains of bacteria that have mechanisms to resist the action of older tetracyclines. The new agent binds to the 30S ribosomal unit, blocks bacterial protein synthesis, and is generally bacteriostatic[1]. Omadacycline tosylate has broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline tosylate has been studied in acute bacterial skin and skin structure infections, community-acquired pneumonia and urinary tract infections.

Uses

OMadacycline (tosylate) is a new type of 9-aminomethylcycline drug, which is a semi-synthetic compound obtained by modifying chemical groups on the basis of minocycline. The modification can help omacycline overcome bacterial resistance. Pharmacological properties, expand the antibacterial spectrum, and improve the pharmacokinetic properties.

Biological Activity

OMadacycline (tosylate) is an aminecycline antibiotic with antibacterial activity against Gram-positive and negative aerobic bacteria and some anaerobic bacteria.

Mode of action

(1) OMadacycline (tosylate) specifically binds to the A site of the 30S subunit of the bacterial ribosome, inhibits the normal binding of aminoacyl-tRNA to this site, terminates the elongation of the peptide chain, and blocks the synthesis of proteins to produce a bacteriostatic effect.
(2) The electron-donating group (dimethylamino) of the modified group of it can improve the activity and help to overcome the bacterial efflux pump resistance mechanism.
(3) The aminomethyl modification of it can make it overcome the bacterial ribosome protection mechanism (caused by the ribosome protection protein gene TetO) and enhance oral bioavailability.
(4) But it cannot resist the effect of Tet(X) modification enzyme.

References

[1] DANIEL A. HUSSAR; Elias B C. Omadacycline tosylate, Sarecycline hydrochloride, Rifamycin sodium, and Moxidectin[J]. Journal of the American Pharmacists Association, 2019. DOI:10.1016/j.japh.2019.07.016.

OMadacycline (tosylate) Preparation Products And Raw materials

Raw materials

Preparation Products

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OMadacycline (tosylate) Suppliers

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View Lastest Price from OMadacycline (tosylate) manufacturers

Biopole Pharmatech Co., Ltd.
Product
Omadacycline Tosylate 1075240-43-5
Price
US $0.00/g
Min. Order
1g
Purity
0.99
Supply Ability
100kg
Release date
2024-01-19

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