OMadacycline (tosylate)
- Product Name
- OMadacycline (tosylate)
- CAS No.
- 1075240-43-5
- Chemical Name
- OMadacycline (tosylate)
- Synonyms
- QTH11;Omycycline;Omacycline Mesylate;Tyrosine Impurity 22;Omadacyeline tosylate;Omadacycline tosylater;OMadacycline (tosylate);Omacycline p-toluene sulfonate;Omadacycline p-Toluenesulfonate;Omachycline p-toluene sulfonate
- CBNumber
- CB22685931
- Molecular Formula
- C36H48N4O10S
- Formula Weight
- 728.86
- MOL File
- 1075240-43-5.mol
OMadacycline (tosylate) Property
- storage temp.
- 4°C, protect from light
- solubility
- Soluble in DMSO
- form
- Solid
- color
- White to yellow
- Water Solubility
- H2O: 2mg/mL, clear
- InChIKey
- SETFNHZTVGTBHC-MPRIKUDSNA-N
- SMILES
- S(C1C=CC(C)=CC=1)(O)(=O)=O.O[C@@]12C(C(C(=O)N)=C(O)[C@@H](N(C)C)[C@]1([H])C[C@]1([H])CC3=C(C=C(CNCC(C)(C)C)C(O)=C3C(=O)C1=C2O)N(C)C)=O |&1:12,20,24,27,r|
N-Bromosuccinimide Price
- Product number
- CS-2465
- Product name
- Omadacycline(tosylate)
- Purity
- 99.37%
- Packaging
- 50mg
- Price
- $1800
- Updated
- 2021/12/16
- Product number
- CS-2465
- Product name
- Omadacycline(tosylate)
- Purity
- 99.37%
- Packaging
- 5mg
- Price
- $312
- Updated
- 2021/12/16
- Product number
- CS-2465
- Product name
- Omadacycline(tosylate)
- Purity
- 99.37%
- Packaging
- 10mg
- Price
- $540
- Updated
- 2021/12/16
- Product number
- CD31004645
- Product name
- Omadacyclinetosylate
- Purity
- 98+%
- Packaging
- 50mg
- Price
- $631
- Updated
- 2021/12/16
- Product number
- CD31004645
- Product name
- Omadacyclinetosylate
- Purity
- 98+%
- Packaging
- 5mg
- Price
- $182
- Updated
- 2021/12/16
OMadacycline (tosylate) Chemical Properties,Usage,Production
Description
Omadacycline tosylate is a semisynthetic tetracycline-class antibacterial agent, which has been designated by some as a “new-generation tetracycline” or “the first in a new class of aminomethylcyclines.” Omadacycline has been structurally modified to provide effectiveness against certain strains of bacteria that have mechanisms to resist the action of older tetracyclines. The new agent binds to the 30S ribosomal unit, blocks bacterial protein synthesis, and is generally bacteriostatic[1]. Omadacycline tosylate has broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline tosylate has been studied in acute bacterial skin and skin structure infections, community-acquired pneumonia and urinary tract infections.
Uses
OMadacycline (tosylate) is a new type of 9-aminomethylcycline drug, which is a semi-synthetic compound obtained by modifying chemical groups on the basis of minocycline. The modification can help omacycline overcome bacterial resistance. Pharmacological properties, expand the antibacterial spectrum, and improve the pharmacokinetic properties.
Biological Activity
OMadacycline (tosylate) is an aminecycline antibiotic with antibacterial activity against Gram-positive and negative aerobic bacteria and some anaerobic bacteria.
Mode of action
(1) OMadacycline (tosylate) specifically binds to the A site of the 30S subunit of the bacterial ribosome, inhibits the normal binding of aminoacyl-tRNA to this site, terminates the elongation of the peptide chain, and blocks the synthesis of proteins to produce a bacteriostatic effect.
(2) The electron-donating group (dimethylamino) of the modified group of it can improve the activity and help to overcome the bacterial efflux pump resistance mechanism.
(3) The aminomethyl modification of it can make it overcome the bacterial ribosome protection mechanism (caused by the ribosome protection protein gene TetO) and enhance oral bioavailability.
(4) But it cannot resist the effect of Tet(X) modification enzyme.
References
[1] DANIEL A. HUSSAR; Elias B C. Omadacycline tosylate, Sarecycline hydrochloride, Rifamycin sodium, and Moxidectin[J]. Journal of the American Pharmacists Association, 2019. DOI:10.1016/j.japh.2019.07.016.
OMadacycline (tosylate) Preparation Products And Raw materials
Raw materials
Preparation Products
OMadacycline (tosylate) Suppliers
- Tel
- 028-68252565 15228763780
- Fax
- 028-82783880
- 1063969897@qq.com
- Country
- China
- ProdList
- 178
- Advantage
- 60
- Tel
- 18980796919
- 236656639@qq.com
- Country
- China
- ProdList
- 23
- Advantage
- 58
- Tel
- 010-88886666-01 13112345678
- Fax
- CDXH21@126.com
- loyson@tcypharm.com
- Country
- China
- ProdList
- 596
- Advantage
- 55
- Tel
- 027-59207796 13429867250
- Fax
- 027-59207796
- w13429867250@163.com
- Country
- China
- ProdList
- 1992
- Advantage
- 58
- Tel
- 021-54285032 18116461626
- Fax
- 021-54285032
- 25493162@qq.com
- Country
- China
- ProdList
- 142
- Advantage
- 58
- Tel
- 0512-0512-62551764 18013103761
- Fax
- 0512-62551799
- sales01@bright-gene.com
- Country
- China
- ProdList
- 61
- Advantage
- 70
- Tel
- 0512-63001269 15720870325
- sales2@biosyntech-suzhou.com
- Country
- China
- ProdList
- 56
- Advantage
- 58
- Tel
- 0512-65974739-0 15151475053
- mengqi_biopole@163.com
- Country
- China
- ProdList
- 51
- Advantage
- 58
- Tel
- 18576690171
- 3001025734@qq.com
- Country
- China
- ProdList
- 11429
- Advantage
- 58
- Tel
- 028-87827187 13419034739
- sales@eastonpharma.cn
- Country
- China
- ProdList
- 63
- Advantage
- 60
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6005
- Advantage
- 61
- Tel
- 025-57798810
- Fax
- 025-57019371
- sales@sunlidabio.com
- Country
- China
- ProdList
- 3239
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7783
- Advantage
- 58
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9647
- Advantage
- 58
- Tel
- 0531-68652053
- 2310993908@qq.com
- Country
- China
- ProdList
- 1557
- Advantage
- 58
- Tel
- +86-21-5821 5861
- Fax
- +86-21-5106 2861
- sales@letopharm.com
- Country
- China
- ProdList
- 2384
- Advantage
- 58
- Tel
- 028-86136736 19130631884
- Fax
- 028-85265615
- sales@mic-pharma.com
- Country
- China
- ProdList
- 307
- Advantage
- 56
- Tel
- 21-619849051-1 18521059765
- synchempharma@aliyun.com
- Country
- China
- ProdList
- 6464
- Advantage
- 55
- Tel
- Fax
- -
- eric_feng1954@126.com
- Country
- China
- ProdList
- 9248
- Advantage
- 55
- Tel
- 18280102635; 18280102635
- Fax
- 028-82252524
- sales@betterwanhe.com
- Country
- China
- ProdList
- 67
- Advantage
- 55
- Tel
- 0317-5296180 15533709196
- Fax
- 0317-5106596
- sale@enkepharma.com
- Country
- China
- ProdList
- 2039
- Advantage
- 55
- Tel
- 17754423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8011
- Advantage
- 62
- Tel
- 028-83379370 13880556291
- Fax
- 028-87747383
- tcy@tcypharm.com
- Country
- China
- ProdList
- 6272
- Advantage
- 58
- Tel
- 021-2022843681 15618226720
- Fax
- +86-21-51601218
- lucy@atkchemical.com
- Country
- China
- ProdList
- 9987
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12306
- Advantage
- 58
- Tel
- 027-59402396 13419635609
- Fax
- 027-83989310
- 13419635609@163.com
- Country
- China
- ProdList
- 1971
- Advantage
- 55
- Tel
- 027-83778876 13667159345
- Fax
- 027-83778876
- 13667159345@163.com
- Country
- China
- ProdList
- 2009
- Advantage
- 55
- Tel
- 027-83778875 15807197853
- Fax
- 027-83991220
- 15807197853@163.com
- Country
- China
- ProdList
- 4035
- Advantage
- 58
- Tel
- 027-83778895 18602735115
- Fax
- 027-51119224
- 18602735115@163.com
- Country
- China
- ProdList
- 1998
- Advantage
- 64
- Tel
- 028-82250492; 15121117545
- Fax
- QQ 3627337140
- viola.liu@medsynbio.cn
- Country
- China
- ProdList
- 99
- Advantage
- 58
- Tel
- 0371-63315541 13323832564
- Fax
- QQ:3001332135
- 3001332135@qq.com
- Country
- China
- ProdList
- 10019
- Advantage
- 58
- Tel
- 13316949107 13316968096
- 1979313431@qq.com
- Country
- China
- ProdList
- 9122
- Advantage
- 58
- Tel
- +86-27-87465837 +8618971612321
- Fax
- 86 27 87772287
- info@finetechnology-ind.com
- Country
- China
- ProdList
- 9638
- Advantage
- 58
- Tel
- +8613073028829
- mack@tongyon.com
- Country
- China
- ProdList
- 2994
- Advantage
- 58
- Tel
- +86-0571-85134551
- Fax
- 008657185134895
- sales@afinechem.com
- Country
- China
- ProdList
- 15352
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30231
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9409
- Advantage
- 58
- Tel
- 13969155946
- 1461866103@qq.com
- Country
- China
- ProdList
- 16111
- Advantage
- 58
- Tel
- 027-59207795 18327179646
- Fax
- 027-59207795
- 18327179646@163.com
- Country
- China
- ProdList
- 1993
- Advantage
- 58
- Tel
- 024-23982345
- 1020788318@qq.com
- Country
- China
- ProdList
- 2251
- Advantage
- 58
- Tel
- 021-38015121 18438616290
- wulan@absin.cn
- Country
- China
- ProdList
- 24731
- Advantage
- 58
- Tel
- +86-18629577295 +86-18629577295
- Fax
- 029-84161958
- magic@lynabio.com
- Country
- China
- ProdList
- 1055
- Advantage
- 55
- Tel
- 0510-83591909 18018392058
- Fax
- 0510-83591909
- info@enbridgepharm.com
- Country
- China
- ProdList
- 226
- Advantage
- 58
- Tel
- 027-027-83984790 17720532645
- Fax
- 027-83984790
- t17720532645@163.com
- Country
- China
- ProdList
- 991
- Advantage
- 58
- Tel
- 027-52344656 15871722230
- Fax
- 2796190295
- 15871722230@163.com
- Country
- China
- ProdList
- 4944
- Advantage
- 58
- Tel
- 027-59506022 13419526507
- Fax
- 027-59506022
- 13419526507@163.com
- Country
- China
- ProdList
- 2972
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44811
- Advantage
- 58
- Tel
- 027-61907345 13397111514
- Fax
- 3443707954
- w13397111514@163.com
- Country
- China
- ProdList
- 1011
- Advantage
- 58
- Tel
- 021-021-52919136 17315815539
- 2804155403@qq.com
- Country
- China
- ProdList
- 168
- Advantage
- 58
- Tel
- 400-880-2824 18107960669
- Fax
- 18140514863
- 79046690@qq.com
- Country
- China
- ProdList
- 1267
- Advantage
- 58
View Lastest Price from OMadacycline (tosylate) manufacturers
- Product
- OMadacycline (tosylate) 1075240-43-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98
- Supply Ability
- 1000
- Release date
- 2025-01-09
- Product
- OMadacycline (tosylate) 1075240-43-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 5kg
- Purity
- 98%-102%
- Supply Ability
- 200kg
- Release date
- 2024-12-27
- Product
- Omadacycline Tosylate 1075240-43-5
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-12-30