2-chloro-6-iodobenzoic acid
- Product Name
- 2-chloro-6-iodobenzoic acid
- CAS No.
- 13420-63-8
- Chemical Name
- 2-chloro-6-iodobenzoic acid
- Synonyms
- 2-chloro-6-iodobenzoic acid;Benzoic acid, 2-chloro-6-iodo-
- CBNumber
- CB22686064
- Molecular Formula
- C7H4ClIO2
- Formula Weight
- 282.46
- MOL File
- 13420-63-8.mol
2-chloro-6-iodobenzoic acid Property
- Melting point:
- 147-149℃ (heptane ethyl acetate )
- Boiling point:
- 333.6±27.0 °C(Predicted)
- Density
- 2.077±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- form
- solid
- pka
- 1.63±0.10(Predicted)
- Appearance
- Yellow to brown Solid
Safety
- RIDADR
- 2811
- WGK Germany
- 3
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- ALD00400
- Product name
- 2-Chloro-6-iodobenzoic acid
- Purity
- 95%
- Packaging
- 1g
- Price
- $114
- Updated
- 2025/07/31
- Product number
- C585848
- Product name
- 2-Chloro-6-iodobenzoic acid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR400966
- Product name
- 2-Chloro-6-iodobenzoic acid
- Packaging
- 5g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- 2621-M-03
- Product name
- 2-Chloro-6-iodobenzoic acid
- Purity
- 95%
- Packaging
- 100mg
- Price
- $395
- Updated
- 2021/12/16
- Product number
- HCH0363608
- Product name
- 2-CHLORO-6-IODOBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.12
- Updated
- 2021/12/16
2-chloro-6-iodobenzoic acid Chemical Properties,Usage,Production
Uses
The following building block was synthesized via a C-H activation method developed by Yu and coworkers. The method was incorporated using the Yu-Wasa Auxiliary (Aldrich 791806) and I2 as the sole oxidant for ortho-iodination from the corresponding benzoic acid derivative.
reaction suitability
reagent type: ligand
reaction type: C-H Activation
Synthesis
118-91-2
13420-63-8
General procedure: In a flame-dried 100 mL round-bottomed flask, 2-chlorobenzoic acid (16.4 mmol, 1.0 eq.), palladium acetate (0.05 eq.), iodobenzene diacetate (1.5 eq.), and iodine (1.5 eq.) were added and dissolved in anhydrous DMF (40 mL), and the reaction system was kept at atmospheric conditions. After sealing the flask with a rubber septum, the reaction mixture was stirred at 100 °C for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate and subsequently washed with 0.5 N HCl solution (420 mL). The organic phase was washed with saturated brine, dried over anhydrous sodium sulfate and finally concentrated in a rotary evaporator. The crude product was purified by silica gel column chromatography (eluent ratio 3:1 hexane/ethyl acetate) to afford the target product 2-chloro-6-iodobenzoic acid.
References
[1] ACS Catalysis, 2018, vol. 8, # 2, p. 920 - 925
[2] Australian Journal of Chemistry, 2015, vol. 68, # 6, p. 912 - 918
[3] Angewandte Chemie - International Edition, 2008, vol. 47, # 28, p. 5215 - 5219
[4] Synthetic Communications, 2005, vol. 35, # 6, p. 799 - 806
2-chloro-6-iodobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-chloro-6-iodobenzoic acid manufacturers
- Product
- 2-chloro-6-iodobenzoic acid 13420-63-8
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-03