P7C3-A20

Product Name: P7C3-A20
CAS No.: 1235481-90-9
Chemical Name: P7C3-A20
Synonyms: CS-2365;P7C3-A20;P7C3-A20, >=98%;N-(3-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-2-FLUOROPROPYL)-3-METHOXYANILINE;9H-Carbazole-9-propanamine, 3,6-dibromo-β-fluoro-N-(3-methoxyphenyl)-;3,6-Dibromo-beta-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine;P7C3-A20 3,6-Dibromo-beta-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine
CBNumber: CB22686079
Molecular Formula: C22H19Br2FN2O
Formula Weight: 506.21
MOL File: 1235481-90-9.mol

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P7C3-A20 Property

Boiling point:: 641.3±55.0 °C(Predicted)
Density: 1.57±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: Soluble in DMSO (40 mg/ml)
pka: 3.25±0.50(Predicted)
form: solid
color: Off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 24201
Product name: P7C3-A20
Purity: ≥95%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 24201
Product name: P7C3-A20
Purity: ≥95%
Packaging: 5mg
Price: $145
Updated: 2024/03/01

Cayman Chemical

Product number: 24201
Product name: P7C3-A20
Purity: ≥95%
Packaging: 10mg
Price: $243
Updated: 2024/03/01

Cayman Chemical

Product number: 24201
Product name: P7C3-A20
Purity: ≥95%
Packaging: 25mg
Price: $480
Updated: 2024/03/01

AK Scientific

Product number: W9492
Product name: P7C3-A20
Packaging: 10mg
Price: $154
Updated: 2021/12/16

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P7C3-A20 Chemical Properties,Usage,Production

Description

P7C3-A20 is a derivative of P7C3 (Item No. 16682) that has proneurogenic and neuroprotective activity. It increases proliferation in the subgranular zone (SGZ) of the adult mouse dentate gyrus in a dose-dependent manner when administered at doses ranging from 0.1 to 10 μM. It also protects U2OS cells from calcium-induced mitochondrial dissolution. In a rat model of traumatic brain injury, P7C3-A20 (10 mg/kg, i.p., twice daily for one week) decreases contusion volume, increases proliferation in the SGZ, and decreases the latency to reach the platform in the Morris water maze to sham surgery control levels. It also prevents or reverses dopaminergic cell death and motor deficits in a 6-OHDA rat model of Parkinson's disease.

References

LoCoco et al. (2017), Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy; Elife, 6 e29626 Blaya et al. (2014), Neuroprotective efficacy of a proneurigenic compound after traumatic brain injury; Neurotrauma, 31 476 Vázquez-Rosa et al. (2020), P7C3-A20 treatment one year after TBI in mice repairs the blood-brain barrier, arrests chronic neurodegeneration, and restores cognition; Proc. Natl. Acad. Sci. USA, 117 27667 Bai et al. (2020), The Small Molecule P7C3-A20 Exerts Neuroprotective Effects in a Hypoxic-ischemic Encephalopathy Model via Activation of PI3K/AKT/GSK3? Signaling; Neuroscience, 441 197 Oku et al. (2017), P7C3 Suppresses Neuroinflammation and Protects Retinal Ganglion Cells of Rats from Optic Nerve Crush; Invest. Ophthamol. Vis. Sci., 58 4877

P7C3-A20 Preparation Products And Raw materials

Raw materials

Preparation Products

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P7C3-A20 Suppliers

China 71 India 1 United Kingdom 1 United States 13 Global 86

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 3445
Advantage: 55

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7856
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2989
Advantage: 60

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

Taizhou Crene Biotechnology Co., Ltd.

Tel: 0576-88813233 88205808
Fax: 0576-88229589
Email: sales@taizhoukerui.com
Country: China
ProdList: 137
Advantage: 57

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4153
Advantage: 55

Shanghai Synchem Pharma Co., ltd

Tel: 021-61984905-1 18016477331
Email: synchempharma@aliyun.com
Country: China
ProdList: 6455
Advantage: 55

ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9638
Advantage: 58

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View Lastest Price from P7C3-A20 manufacturers

Career Henan Chemical Co

Product: P7C3-A20 1235481-90-9
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 95%~99%
Supply Ability: per week:100kg
Release date: 2019-09-05

1235481-90-9, P7C3-A20Related Search:

KU57788(NU7441) RESINIFERATOXIN N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) Volasertib (BI 6727)

P7C3-A20 3,6-Dibromo-beta-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine

P7C3-A20, >=98%

P7C3-A20

N-(3-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-2-FLUOROPROPYL)-3-METHOXYANILINE

3,6-Dibromo-beta-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine

CS-2365

9H-Carbazole-9-propanamine, 3,6-dibromo-β-fluoro-N-(3-methoxyphenyl)-

1235481-90-9

C22H19Br2FN2O

Inhibitors