P7C3-A20

Product Name: P7C3-A20
CAS No.: 1235481-90-9
Chemical Name: P7C3-A20
Synonyms: CS-2365;P7C3-A20;P7C3-A20, >=98%;N-(3-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-2-FLUOROPROPYL)-3-METHOXYANILINE;9H-Carbazole-9-propanamine, 3,6-dibromo-β-fluoro-N-(3-methoxyphenyl)-;3,6-Dibromo-beta-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine;P7C3-A20 3,6-Dibromo-beta-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine
CBNumber: CB22686079
Molecular Formula: C22H19Br2FN2O
Formula Weight: 506.21
MOL File: 1235481-90-9.mol

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P7C3-A20 Property

Boiling point:: 641.3±55.0 °C(Predicted)
Density: 1.57±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: Soluble in DMSO (40 mg/ml)
pka: 3.25±0.50(Predicted)
form: solid
color: Off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 24201
Product name: P7C3-A20
Purity: ≥95%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 24201
Product name: P7C3-A20
Purity: ≥95%
Packaging: 5mg
Price: $145
Updated: 2024/03/01

Cayman Chemical

Product number: 24201
Product name: P7C3-A20
Purity: ≥95%
Packaging: 10mg
Price: $243
Updated: 2024/03/01

Cayman Chemical

Product number: 24201
Product name: P7C3-A20
Purity: ≥95%
Packaging: 25mg
Price: $480
Updated: 2024/03/01

AK Scientific

Product number: W9492
Product name: P7C3-A20
Packaging: 10mg
Price: $154
Updated: 2021/12/16

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P7C3-A20 Chemical Properties,Usage,Production

Description

P7C3-A20 is a derivative of P7C3 (Item No. 16682) that has proneurogenic and neuroprotective activity. It increases proliferation in the subgranular zone (SGZ) of the adult mouse dentate gyrus in a dose-dependent manner when administered at doses ranging from 0.1 to 10 μM. It also protects U2OS cells from calcium-induced mitochondrial dissolution. In a rat model of traumatic brain injury, P7C3-A20 (10 mg/kg, i.p., twice daily for one week) decreases contusion volume, increases proliferation in the SGZ, and decreases the latency to reach the platform in the Morris water maze to sham surgery control levels. It also prevents or reverses dopaminergic cell death and motor deficits in a 6-OHDA rat model of Parkinson's disease.

References

LoCoco et al. (2017), Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy; Elife, 6 e29626 Blaya et al. (2014), Neuroprotective efficacy of a proneurigenic compound after traumatic brain injury; Neurotrauma, 31 476 Vázquez-Rosa et al. (2020), P7C3-A20 treatment one year after TBI in mice repairs the blood-brain barrier, arrests chronic neurodegeneration, and restores cognition; Proc. Natl. Acad. Sci. USA, 117 27667 Bai et al. (2020), The Small Molecule P7C3-A20 Exerts Neuroprotective Effects in a Hypoxic-ischemic Encephalopathy Model via Activation of PI3K/AKT/GSK3? Signaling; Neuroscience, 441 197 Oku et al. (2017), P7C3 Suppresses Neuroinflammation and Protects Retinal Ganglion Cells of Rats from Optic Nerve Crush; Invest. Ophthamol. Vis. Sci., 58 4877

P7C3-A20 Preparation Products And Raw materials

Raw materials

Preparation Products

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P7C3-A20 Suppliers

China 77 India 1 United Kingdom 1 United States 13 Global 92

MedChemexpress LLC

Tel: 021-58955995
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Target molecule Corp.

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Musechem

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TargetMol Chemicals Inc.

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InvivoChem

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Cckinase, Inc.

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BOC Sciences

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Aladdin Scientific

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Focus Biomolecules

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Cayman Chemical Company

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United States Biological

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Combi-Blocks Inc.

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SynInnova Laboratories Inc.

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View Lastest Price from P7C3-A20 manufacturers

Career Henan Chemical Co

Product: P7C3-A20 1235481-90-9
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 95%~99%
Supply Ability: per week:100kg
Release date: 2019-09-05

1235481-90-9, P7C3-A20Related Search:

KU57788(NU7441) RESINIFERATOXIN N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) Volasertib (BI 6727)

P7C3-A20 3,6-Dibromo-beta-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine

P7C3-A20, >=98%

P7C3-A20

N-(3-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-2-FLUOROPROPYL)-3-METHOXYANILINE

3,6-Dibromo-beta-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine

CS-2365

9H-Carbazole-9-propanamine, 3,6-dibromo-β-fluoro-N-(3-methoxyphenyl)-

1235481-90-9

C22H19Br2FN2O

Inhibitors