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AMpkinone

Product Name
AMpkinone
CAS No.
1233082-79-5
Chemical Name
AMpkinone
Synonyms
CS-2123;AMpkinone;[1]Benzopyrano[3,4-e]isoindole-1,3(2H,4H)-dione, 2-(4-benzoylphenyl)-6-hydroxy-7-methoxy-4,4-dimethyl-
CBNumber
CB22695626
Molecular Formula
C31H23NO6
Formula Weight
505.52
MOL File
1233082-79-5.mol
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AMpkinone Property

Boiling point:
732.7±70.0 °C(Predicted)
Density 
1.353±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≤2mg/ml in DMSO;10mg/ml in dimethyl formamide
form 
crystalline solid
pka
9.01±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10631
Product name
Ampkinone
Purity
≥95%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
10631
Product name
Ampkinone
Purity
≥95%
Packaging
5mg
Price
$220
Updated
2024/03/01
Cayman Chemical
Product number
10631
Product name
Ampkinone
Purity
≥95%
Packaging
10mg
Price
$384
Updated
2024/03/01
Usbiological
Product number
162633
Product name
Ampkinone
Packaging
2.5mg
Price
$382
Updated
2021/12/16
TRC
Product number
A634330
Product name
Ampkinone
Packaging
2.5mg
Price
$100
Updated
2021/12/16
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AMpkinone Chemical Properties,Usage,Production

Uses

Ampkinone is a novel small molecule activator of AMP-activated protein kinase. Ampkinone was shown to exhibit antidiabetic and antiobesity effects.

Biological Activity

ampkinone is an ampk activator.adenosine 5'-monophosphate (amp) activated protein kinase (ampk) has considered as an promising target molecule for the treatment of metabolic disorders, such as obesity and type 2 diabetes.

in vitro

ampkinone was identified as an indirect ampk activator, which was derived from the small molecule library constructed by diversity-oriented synthesis. ampkinone was able to stimulate the phosphorylation of ampk through the indirect activation of ampk in various cell lines. moreover, ampkinone-mediated activation of ampk needed the activity of lkb1 and led to increased glucose uptake in muscle cells [1].

in vivo

animal study found that ampkinone-treated dio mice had significantly reduced total body weight and overall fat mass. histological examination and measurement of lipid parameters showed that ampkinone could effectively improve metabolic abnormalities. these results demonstrated that ampkinone had a potential as a new class of therapeutic agent for antidiabetic and antiobesity treatment through the indirect stimulation of ampk [1].

References

[1] oh, s. ,kim, s.j.,hwang, j.h., et al. antidiabetic and antiobesity effects of ampkinone (6f), a novel small molecule activator of amp-activated protein kinase. journal of medicinal chemistry 53, 7405-7413 (2010).

AMpkinone Preparation Products And Raw materials

Raw materials

Preparation Products

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AMpkinone Suppliers

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Haoyuan Chemexpress Co., Ltd.
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021-58950125
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(86) 21-58955996
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Shanghai TaoSu Biochemical Technology Co., Ltd.
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021-33632979
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Guangzhou QiYun Biotechnology Co., Ltd.
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020-61288194 61288195
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Shanghai Rechem science Co., Ltd.
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21-31433387 15618786686
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QQ:1369748377
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sales@rechemscience.com
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Musechem
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+1-800-259-7612
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United States
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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+86-400-002-6226 13028896684
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Fan De(Beijing) Biotechnology Co., Ltd.
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15911056312
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
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1233082-79-5, AMpkinoneRelated Search:


  • CS-2123
  • AMpkinone
  • [1]Benzopyrano[3,4-e]isoindole-1,3(2H,4H)-dione, 2-(4-benzoylphenyl)-6-hydroxy-7-methoxy-4,4-dimethyl-
  • 1233082-79-5
  • Aromatics, Amines, Pharmaceuticals, Intermediates & Fine Chemicals