5’O-Tritylinosine

Product Name: 5’O-Tritylinosine
CAS No.: 4152-77-6
Chemical Name: 5’O-Tritylinosine
Synonyms: KIN-59;5'-O-Trt-rI;5’O-Tritylinosine;5’-O-Tritylinosine;Inosine, 5'-O-(triphenylmethyl)-;5′-O-Tritylinosine, CAS 4152-77-6;5'-O-tritylinosine-2'-deoxyinosine
CBNumber: CB22701680
Molecular Formula: C29H26N4O5
Formula Weight: 510.54
MOL File: 4152-77-6.mol

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5’O-Tritylinosine Property

solubility: DMF: 5 mg/mL; DMSO: 16 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL; Ethanol: 0.3 mg/mL
form: A crystalline solid
color: White to off-white
InChIKey: YEPZMZDCXFRHCL-ZYWWQZICSA-N
SMILES: O(C(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3C(=C(N=CN=3)O)N=C2)[C@H](O)[C@@H]1O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19833
Product name: KIN-59
Purity: ≥98%
Packaging: 10mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 19833
Product name: KIN-59
Purity: ≥98%
Packaging: 50mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 19833
Product name: KIN-59
Purity: ≥98%
Packaging: 100mg
Price: $208
Updated: 2024/03/01

TRC

Product number: T888600
Product name: 5’-O-Tritylinosine
Packaging: 100mg
Price: $155
Updated: 2021/12/16

ApexBio Technology

Product number: C4148
Product name: KIN-59
Packaging: 50mg
Price: $130
Updated: 2021/12/16

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5’O-Tritylinosine Chemical Properties,Usage,Production

Description

KIN59 is a purine riboside derivative that allosterically inhibits thymidine phosphorylase (TPase; IC₅₀s = 44 and 67 μM for purified E. coli and human enzymes, respectively). Through this action, KIN59 blocks the conversion of thymidine to thymine. KIN59 inhibits TPase-induced angiogenesis in a chicken chorioallantoic membrane assay and reduces endothelial cell migration without impacting proliferation. KIN59 also inhibits the binding of fibroblast growth factor 2 (FGF2) to FGF receptor 1, preventing the growth and neovascularization of subcutaneous tumors induced by FGF2-transformed endothelial cells injected in immunodeficient nude mice.

Uses

5’O-Tritylinosine acts as an allosteric inhibitor of angiogenic enzyme thymidine phosphorylase.

Uses

5’-O-Tritylinosine acts as an allosteric inhibitor of angiogenic enzyme thymidine phosphorylase.

in vivo

KIN59 (15 mg/kg; s.c.; twice daily from day 2 for 20 days) shows anti-tumor activity in mice^[1].

Animal Model:	Eight-week-old female, 25 g, athymic, nude nu/nu mice (F2T-luc2.9 cellss)^[1]
Dosage:	15 mg/kg
Administration:	S.c.; twice daily from day 2 (once daily during the weekend) at a site distant from the tumor (inoculation) site for 20 days
Result:	Caused a significant inhibition in the rate of tumor growth.

References

[1] SANDRA LIEKENS. The nucleoside derivative 5’-O-trityl-inosine (KIN59) suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action.[J]. The Journal of Biological Chemistry, 2004, 279 28: 29598-29605. DOI: 10.1074/jbc.m402602200
[2] SANDRA LIEKENS. 5’-O-tritylated nucleoside derivatives: inhibition of thymidine phosphorylase and angiogenesis.[J]. Molecular Pharmacology, 2006, 70 2: 501-509. DOI: 10.1124/mol.105.021188
[3] SANDRA LIEKENS. The thymidine phosphorylase inhibitor 5’-O-tritylinosine (KIN59) is an antiangiogenic multitarget fibroblast growth factor-2 antagonist.[J]. Molecular Cancer Therapeutics, 2012, 11 4: 817-829. DOI: 10.1158/1535-7163.mct-11-0738

5’O-Tritylinosine Preparation Products And Raw materials

Raw materials

Preparation Products

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5’O-Tritylinosine Suppliers

Canada 1 CHINA 27 India 1 United Kingdom 1 United States 4 Global 34

Shanghai shuodian Biotechnology Co., Ltd

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J & K SCIENTIFIC LTD.

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Energy Chemical

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Xi'an Kezhan Biotechnology Co., Ltd.

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View Lastest Price from 5’O-Tritylinosine manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: 5’O-Tritylinosine 4152-77-6
Price: US $0.00-0.00/G
Min. Order: 1G
Purity: 98%
Supply Ability: 2000
Release date: 2025-06-04

4152-77-6, 5’O-TritylinosineRelated Search:

5’O-Tritylinosine

KIN-59

Inosine, 5'-O-(triphenylmethyl)-

5'-O-tritylinosine-2'-deoxyinosine

5'-O-Trt-rI

5’-O-Tritylinosine

5′-O-Tritylinosine, CAS 4152-77-6

4152-77-6