ChemicalBook > CAS DataBase List > TUG 891

TUG 891

Product Name: TUG 891
CAS No.: 1374516-07-0
Chemical Name: TUG 891
Synonyms: CS-2448;TUG 891;TUG-891 ，S6775;TUG 891;TUG-891;GPR120 Agonist III;TUG-891, 10 mM in DMSO;Inhibitor,inhibit,Free Fatty Acid Receptor,TUG-891,FFAR;4-[(4-Fluoro-4'-methyl-biphenyl-2-yl)methoxy]benzenepropanoic acid;3-{4-[(4-Fluoro-4'-methyl-2-biphenylyl)methoxy]phenyl}propanoic acid;3-(4-{[5-fluoro-2-(4-methylphenyl)phenyl]methoxy}phenyl)propanoic acid
CBNumber: CB22701695
Molecular Formula: C23H21FO3
Formula Weight: 364.41
MOL File: 1374516-07-0.mol

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TUG 891 Property

Boiling point:: 540.8±50.0 °C(Predicted)
Density: 1.199±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO:30.0(Max Conc. mg/mL);82.32(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);13.72(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);2.74(Max Conc. mM)
form: Powder
pka: 4.70±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1914
Product name: TUG-891
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $108
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1914
Product name: TUG-891
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $305.2
Updated: 2025/07/31

Cayman Chemical

Product number: 17035
Product name: TUG-891
Purity: ≥98%
Packaging: 1mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 17035
Product name: TUG-891
Purity: ≥98%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 17035
Product name: TUG-891
Purity: ≥98%
Packaging: 10mg
Price: $166
Updated: 2024/03/01

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TUG 891 Chemical Properties,Usage,Production

Uses

TUG 891 is a potent and selective GPR120 agonist as a new potential target for treatment of type 2 diabetes and metabolic diseases.

Biological Activity

TUG-891 is an orally active, potent and selective agonist for human long chain free fatty acid (FFA) receptor FFA4/GPR120 (pEC50 of receptor β-arrestin-2 recruitment = 7.36/FFA4 vs. 4.19/FFA1 HEK transfectants; pEC50 of calcium mobilization = 7.02/FFA4 vs. 5.30/FFA1 transfectants), while exhibiting no activity toward human short-chain FFA receptors FFA2/GPR43 and FFA3/GPR41. TUG-891 also exhibits potent partial agonist activity toward murine FFA4 (pEC50 = 7.77, 75% efficacy by β-arrestin-2 recruitment assay; pEC50 = 6.89 by calcium mobilization), albeit with a reduced selectivity over mFFA1 (pEC50 = 5.92 by β-arrestin-2 recruitment and 6.41 by by calcium mobilization). When administered via water intake (~20 mg/kg/day), TUG-891 is reported to reverse food intake increases and body weight gains among mice subjected to sleep fragmentation, and significantly attenuate visceral white adipose tissue inflammation as well as insulin resistance.', 'TUG-891, a GPR120 agonist helps to stimulate metabolic health by inducing mitochondrial respiration in brown fat. It is capable of enhancing lipid oxidation and decreasing f at mass in mice.

storage

Store at RT

TUG 891 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from TUG 891 manufacturers

Career Henan Chemical Co

Product: TUG 891 1374516-07-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-25

1374516-07-0, TUG 891Related Search:

TUG-770 TUG-469 4-[2-(2-methylphenyl)ethynyl]-benzenepropanoicacid

TUG 891

4-[(4-Fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]-benzenepropanoic acid

CS-2448

TUG 891;TUG-891

Benzenepropanoic acid, 4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]-

3-(4-{[5-fluoro-2-(4-methylphenyl)phenyl]methoxy}phenyl)propanoic acid

Inhibitor,inhibit,Free Fatty Acid Receptor,TUG-891,FFAR

3-{4-[(4-Fluoro-4'-methyl-2-biphenylyl)methoxy]phenyl}propanoic acid

3-(4-((4-fluoro-4'-methyl-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoicacid

4-[(4-Fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]benzenepropanoic acid

TUG-891, 10 mM in DMSO

GPR120 Agonist III

TUG-891 ，S6775

4-[(4-Fluoro-4'-methyl-biphenyl-2-yl)methoxy]benzenepropanoic acid

1374516-07-0

C23H21FO3