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TetroMycin B

Product Name
TetroMycin B
CAS No.
180027-84-3
Chemical Name
TetroMycin B
Synonyms
TetroMycin B;18H-16a,19-Metheno-16aH-benzo[b]naphth[2,1-j]oxacyclotetradecin-18,20(1H)-dione, 2,3,4,4a,6a,9,10,12a,15,16,20a,20b-dodecahydro-4,21-trihydroxy-1,6,7,11,12a,14,15,20a-octamethyl-, (1S,4S,4aS,6aR,7E,11E,12aR,15R,16aS,20aS,20bR)- (9CI)
CBNumber
CB22703770
Molecular Formula
C34H46O5
Formula Weight
534.72604
MOL File
180027-84-3.mol
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TetroMycin B Property

Boiling point:
680.0±55.0 °C(Predicted)
Density 
1.17±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
form 
A solid
pka
4.50±1.00(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23766
Product name
Tetromycin B
Purity
≥99%
Packaging
500μg
Price
$255
Updated
2024/03/01
Cayman Chemical
Product number
23766
Product name
Tetromycin B
Purity
≥99%
Packaging
2.5mg
Price
$1143
Updated
2024/03/01
TRC
Product number
T309510
Product name
TetromycinB
Packaging
500μg
Price
$230
Updated
2021/12/16
Usbiological
Product number
T3530-05
Product name
Tetromycin B
Packaging
500ug
Price
$523
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0012606
Product name
TETROMYCIN B
Purity
95.00%
Packaging
5MG
Price
$498.32
Updated
2021/12/16
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TetroMycin B Chemical Properties,Usage,Production

Description

Tetromycin B is a cysteine protease inhibitor with Ki values of 0.62, 1.42, 32.5, and 1.59 μM for rhodesain, falcipain-2, cathepsin L, and cathepsin B, respectively. It inhibits the growth of T. brucei in vitro (IC50 = 30.87 μM). Tetromycin B is also cytotoxic to HEK293T kidney cells and J774.1 macrophages (IC50s = 71.77 and 20.2 μM, respectively).

Uses

Tetromycin B is an unusual tetronic acid, structurally related to kijanimicin, chlorothricin, saccharocarcin, tetrocarcin and versipelostatin. Tetromycin B has pronounced activity against antibiotic susceptible and resistant Gram positive bacteria including MRSA. Limited availability has restricted further investigation of this metabolite in the literature. Several members of this class have received considerable literature focus. Versipelostatin inhibits transcription from the promoter of GRP78, a gene that is activated as part of a stress signalling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action is seen only in conditions of glucose deprivation and causes selective and massive killing of the glucose-deprived cells. Tetrocarcin A appears to target the phosphatidylinositide-3'-kinase/Akt signalling pathway.

Uses

Tetromycin B is an unusual tetronic acid structured antibiotic showing efficacy against MRSA.

References

[1] SHEILA M PIMENTEL-ELARDO. New tetromycin derivatives with anti-trypanosomal and protease inhibitory activities.[J]. Marine Drugs, 2011, 9 10: 1682-1697. DOI: 10.3390/md9101682

TetroMycin B Preparation Products And Raw materials

Raw materials

Preparation Products

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TetroMycin B Suppliers

China 21 India 1 United Kingdom 1 United States 5 Global 28
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Meng Cheng Technology (Shanghai) Co., LTD
Tel
400-820-6829
Email
sales@mitachieve.com
Country
China
ProdList
8860
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Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
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Shanghai Saikerui Biotechnology Co. , Ltd.
Tel
021-58000709 15900491054
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China
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Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627
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customer_service@efebio.com
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China
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Nanjing Shizhou Biology Technology Co.,Ltd
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025-85560043 15850508050
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025-85563444
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cindy.huang@synzest.com
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China
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Hubei Danding Pharmaceutical Technology Co., Ltd
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17701422019
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1559451077@qq.com
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China
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Shanghai Weiyite Biotechnology Co., Ltd
Tel
15317051735
Email
zhaojing@wytsci.com
Country
China
ProdList
9980
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58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
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Neobioscience Co., Ltd.
Tel
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CHINA
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Absin Bioscience Inc.
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Beijing Sizhengbai Biotechnology Co., Ltd.
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marketing@4abio.com
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Boao Pike
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lyn@biopike.com.cn
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Shanghai Bosheng Biotechnology Co., Ltd.
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1310057982@qq.com
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Shanghai Hao Biological Technology Co., Ltd.
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shxiyuanbio@163.com
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Beijing Fubo Biotechnology Co., Ltd.
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6170
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Beijing Bolide Biotechnology Co., Ltd.
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180027-84-3, TetroMycin BRelated Search:


  • TetroMycin B
  • 18H-16a,19-Metheno-16aH-benzo[b]naphth[2,1-j]oxacyclotetradecin-18,20(1H)-dione, 2,3,4,4a,6a,9,10,12a,15,16,20a,20b-dodecahydro-4,21-trihydroxy-1,6,7,11,12a,14,15,20a-octamethyl-, (1S,4S,4aS,6aR,7E,11E,12aR,15R,16aS,20aS,20bR)- (9CI)
  • 180027-84-3