(2S,5S)-5-hydroxypiperidine-2-carboxylic acid hydrochloride
- Product Name
- (2S,5S)-5-hydroxypiperidine-2-carboxylic acid hydrochloride
- CAS No.
- 154307-84-3
- Chemical Name
- (2S,5S)-5-hydroxypiperidine-2-carboxylic acid hydrochloride
- Synonyms
- EOS-62364;(2S,5S)-5-hydroxypiperidine-2-carboxylic acid hydrochloride;(2S,5S)-5-hydroxypiperidine-2-carboxylic acid hydrogen chloride;2-Piperidinecarboxylic acid, 5-hydroxy-, hydrochloride (1:1), (2S,5S)-
- CBNumber
- CB22703907
- Molecular Formula
- C6H12ClNO3
- Formula Weight
- 181.62
- MOL File
- 154307-84-3.mol
(2S,5S)-5-hydroxypiperidine-2-carboxylic acid hydrochloride Property
- storage temp.
- Inert atmosphere,Room Temperature
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H879565
- Product name
- (2S,5S)-5-Hydroxypiperidine-2-carboxylicacidhydrochloride
- Packaging
- 50mg
- Price
- $285
- Updated
- 2021/12/16
- Product number
- 4H58-5-4B
- Product name
- (2S,5S)-5-Hydroxypiperidine-2-carboxylic acid hydrochloride
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $820
- Updated
- 2021/12/16
- Product number
- CD11248346
- Product name
- (2S,5S)-5-Hydroxypiperidine-2-carboxylicacidhydrochloride
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1030
- Updated
- 2021/12/16
- Product number
- 154307843
- Product name
- (2S,5S)-5-Hydroxypiperidine-2-carboxylicacidhydrochloride
- Packaging
- 1g
- Price
- $1035.5
- Updated
- 2021/12/16
- Product number
- CM107164
- Product name
- (2s,5s)-5-hydroxypiperidine-2-carboxylicacidhydrochloride
- Purity
- 97%
- Packaging
- 5g
- Price
- $1155
- Updated
- 2021/12/16
(2S,5S)-5-hydroxypiperidine-2-carboxylic acid hydrochloride Chemical Properties,Usage,Production
Synthesis
1383814-52-5
154307-84-3
The general procedure for the synthesis of (2S,5S)-5-hydroxypiperidine-2-carboxylic acid hydrochloride from the compound (CAS:1383814-52-5) is as follows: Step 1: Preparation of (2S,5S)-5-hydroxypiperidine-2-carboxylic acid hydrochloride (2S,5S)-5-hydroxypiperidine-2-carboxylic acid tert-butyl ester (126.22 g, 0.63 mol) was gradually added to 5 M hydrochloric acid (630 mL) at room temperature, followed by heating to 65 °C and stirring for 2 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and the solvent was removed by concentration under reduced pressure. The residue was dissolved in water (500 mL), activated carbon (6.5 g) was added and stirred at room temperature for 30 minutes. The activated carbon was removed by diatomaceous earth filtration and the diatomaceous earth was washed twice with (100 mL) water, the filtrates were combined and concentrated under reduced pressure. The resulting residue (150 g) was cooled in an ice bath, inoculated and stirred. Acetone (650 mL) was added slowly and dropwise over 30 minutes and stirring was continued for 30 minutes. The precipitated crystals were filtered under argon protection and washed with acetone. The crystals were dried under vacuum overnight to give 108.79 g of (2S,5S)-5-hydroxypiperidine-2-carboxylic acid hydrochloride as colorless powdery crystals (96% yield). 1H NMR (400 MHz, D2O) δ 1.66-2.23 (m, 4H), 3.25 (d, J = 3.4 Hz, 1H), 3.38 (d, J = 3.4 Hz, 1H), 4.00 (dd, J = 11.7, 3.7 Hz, 1H), 4.22 (brs, 1H); MS m/z: 146 (M-HCl + H)+.
References
[1] Patent: EP2857401, 2015, A1. Location in patent: Paragraph 0646
(2S,5S)-5-hydroxypiperidine-2-carboxylic acid hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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