4-BroMo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
- Product Name
- 4-BroMo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
- CAS No.
- 1022158-35-5
- Chemical Name
- 4-BroMo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
- Synonyms
- 4-bromo-1-(oxan-2-yl)indazole;4-bromo-1-(oxan-2-yl)-1H-indazole;4-bromo-1-(oxepan-2-yl)-1H-indazole;4-Bromo-1-(tetrahydropyran-2-yl)-1H-indazole;4-BroMo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole;1H-Indazole, 4-bromo-1-(tetrahydro-2H-pyran-2-yl)-
- CBNumber
- CB22704388
- Molecular Formula
- C12H13BrN2O
- Formula Weight
- 281.15
- MOL File
- 1022158-35-5.mol
4-BroMo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole Property
- Melting point:
- 51-52 °C
- Boiling point:
- 405.5±35.0 °C(Predicted)
- Density
- 1.60±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -0.22±0.30(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B678268
- Product name
- 4-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
- Packaging
- 500mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- B678268
- Product name
- 4-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 4H56-9-70
- Product name
- 4-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- HCH0419512
- Product name
- 4-BROMO-1-(TETRAHYDRO-2H-PYRAN-2-YL)-1H-INDAZOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.3
- Updated
- 2021/12/16
- Product number
- 4H56-9-70
- Product name
- 4-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
- Packaging
- 1g
- Price
- $225
- Updated
- 2021/12/16
4-BroMo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole Chemical Properties,Usage,Production
Synthesis
110-87-2
186407-74-9
1022158-35-5
The general procedure for the synthesis of 4-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole from 3,4-dihydro-2H-pyran and 4-bromo-1H-indazole was as follows: 3,4-dihydro-2H-pyran (5.36 mL, 58.57 mmol) was added to a solution of 3,4-dihydro-2H-pyran (5.36 mL, 58.57 mmol) containing 4-bromo-1H-indazole (5.77 g, 29.3 mmol) and 4-bromo-1H-sulphonic acid ( 0.176 g, 1.02 mmol) in a solution of ethyl acetate (60 mL). The reaction mixture was heated and stirred at 70 °C for 16 hours. After the reaction was completed, the mixture was cooled to room temperature and neutralized by adding saturated aqueous sodium bicarbonate solution (50 mL). The organic and aqueous phases were separated and the aqueous phase was extracted with ethyl acetate (10 mL). The organic layers were combined and washed sequentially with saturated aqueous sodium bicarbonate (10 mL) and saturated aqueous sodium chloride (10 mL). The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting brown oil was purified by fast silica gel column chromatography with the eluent being a heptane solution of 10% ethyl acetate. The product fraction was collected and the solvent was evaporated under reduced pressure to give 4-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole (7.78 g, 94% yield) as a white solid. The product was confirmed by 1H NMR (400 MHz, CDCl3, 30 °C): δ 1.60-1.88 (3H, m), 2.03-2.23 (2H, m), 2.55 (1H, dddd), 3.73 (1H, dddd), 4.00 (1H, dddd), 5.71 (1H, dddd), 7.19-7.24 (1H, m), and 7.32 (1H, dd), 7.55 (1H, dd), 8.03 (1H, d).
References
[1] Patent: WO2017/182495, 2017, A1. Location in patent: Page/Page column 114-115
[2] Patent: WO2008/51494, 2008, A1. Location in patent: Page/Page column 159
[3] Asian Journal of Chemistry, 2011, vol. 23, # 1, p. 451 - 454
[4] Patent: US2018/111931, 2018, A1. Location in patent: Paragraph 0882; 0883
[5] Synlett, 2009, # 4, p. 615 - 619
4-BroMo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole Preparation Products And Raw materials
Raw materials
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