Tosufloxacin p-Toluenesulfonate Hydrate

Product Name: Tosufloxacin p-Toluenesulfonate Hydrate
CAS No.: 1400591-39-0
Chemical Name: Tosufloxacin p-Toluenesulfonate Hydrate
Synonyms: T-3262 Tosylate Hydrate;A-61827 tosylate hydrate;Tosufloxacin (tosylate hydrate);Tosufloxacin tosylate hydrate, 10 mM in DMSO;Tosufloxacin tosylate hydrate (T3262, A61827);Tosufloxacin p-Toluenesulfonate Hydrate;Tosufloxacin toluenesulfonate hydrate - Bio-X ?;1,8-Naphthyridine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, 4-methylbenzenesulfonate, hydrate (1:1:)
CBNumber: CB22709949
Molecular Formula: C26H23F3N4O6S
Formula Weight: 576.55
MOL File: 1400591-39-0.mol

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Tosufloxacin p-Toluenesulfonate Hydrate Property

storage temp.: Store at -20°C
solubility: DMSO : ≥ 33 mg/mL (55.50 mM)
form: Solid
color: White to off-white

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Safety

RTECS: QN2791000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T2506
Product name: Tosufloxacin p-Toluenesulfonate Hydrate
Purity: >98.0%(HPLC)
Packaging: 5g
Price: $151
Updated: 2021/12/16

ChemScene

Product number: CS-5713
Product name: Tosufloxacin(tosylatehydrate)
Purity: 99.17%
Packaging: 200mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-5713
Product name: Tosufloxacin(tosylatehydrate)
Purity: 99.17%
Packaging: 1g
Price: $108
Updated: 2021/12/16

Chem-Impex

Product number: 38451
Product name: Tosufloxacinp-toluenesulfonatehydrate,98%(HPLC)
Purity: 98%(HPLC)
Packaging: 5G
Price: $165.76
Updated: 2021/12/16

ChemScene

Product number: CS-5713
Product name: Tosufloxacin(tosylatehydrate)
Purity: 99.17%
Packaging: 5g
Price: $180
Updated: 2021/12/16

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Tosufloxacin p-Toluenesulfonate Hydrate Chemical Properties,Usage,Production

Uses

Tosufloxacin tosylate hydrate (A-61827) is an orally active fluoroquinolone antibiotic. Tosufloxacin shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria[1][2].

Definition

ChEBI: A racemate comprising equimolar amounts of (R)- and (S)-tosufloxacin tosylate hydrate.

in vivo

Tosufloxacin tosylate hydrate (T-3262) (oral gavage; 0.16-13.39 mg/kg; once) treatment shows antibacterial activity against S. aureus, E. coli, and P. aeruginosa in vivo^[2].

Animal Model:	Male Slc:ICR mice infected with S. aureus^[2]
Dosage:	1.27-2.15 mg/kg
Administration:	Oral gavage; 1.27-2.15 mg/kg; once
Result:	Showed 50% effective dose (ED₅₀) of 1.62 mg/kg (body weight) at 7 days after infection. Showed MIC value of 0.0125 μg/mL.

Animal Model:	Male Slc:ICR mice infected with E. coli^[2]
Dosage:	0.16-0.30 mg/kg
Administration:	Oral gavage; 0.16-0.30 mg/kg; once
Result:	Showed 50% effective dose (ED₅₀) of 0.22 mg/kg (body weight) at 7 days after infection. Showed MIC value of 0.0125 μg/mL.

Animal Model:	Male Slc:ICR mice infected with P. aeruginosa^[2]
Dosage:	7.66-13.39 mg/kg
Administration:	Oral gavage; 7.66-13.39 mg/kg; once
Result:	Showed 50% effective dose (ED₅₀) of 10.13 mg/kg (body weight) at 7 days after infection. Showed MIC value of 0.78 μg/mL.

IC 50

Quinolone

References

[1] Chu DT, et al. Synthesis and biological properties of A-71497: a prodrug of tosufloxacin. Drugs Exp Clin Res. 1990;16(9):435-43. PMID:2100244
[2] Fujimaki K, et al. In vitro and in vivo antibacterial activities of T-3262, a new fluoroquinolone. Antimicrob Agents Chemother. 1988 Jun;32(6):827-33. DOI:10.1128/AAC.32.6.827

Tosufloxacin p-Toluenesulfonate Hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Tosufloxacin p-Toluenesulfonate Hydrate Suppliers

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1400591-39-0, Tosufloxacin p-Toluenesulfonate HydrateRelated Search:

Tosufloxacin (tosylate hydrate)

Tosufloxacin <i>p</i>-Toluenesulfonate Hydrate

1,8-Naphthyridine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, 4-methylbenzenesulfonate, hydrate (1:1:)

A-61827 tosylate hydrate

T-3262 Tosylate Hydrate

Tosufloxacin tosylate hydrate (T3262, A61827)

Tosufloxacin tosylate hydrate, 10 mM in DMSO

Tosufloxacin toluenesulfonate hydrate - Bio-X ?

1400591-39-0