AR7

ChemicalBook > CAS DataBase List > AR7

Product Name: AR7
CAS No.: 80306-38-3
Chemical Name: AR7
Synonyms: AR7;ERBA;ERB-T-1;CS-2649;c-ERBA-1;MGC43240;AR7;AR 7;MGC000261;AR 7(RARα agonist);Atypical retinoid 7
CBNumber: CB22714659
Molecular Formula: C15H12ClNO
Formula Weight: 257.71
MOL File: 80306-38-3.mol

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AR7 Property

storage temp.: Sealed in dry,2-8°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Safety

Hazard Codes: N
Risk Statements: 50/53
Safety Statements: 60-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SRP2127
Product name: TR, α1, GST tagged human
Purity: recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
Packaging: 10μG
Price: $400
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0921
Product name: AR7
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: SRP2046
Product name: Thyroid Hormone receptor,α1 human
Purity: recombinant, expressed in insect cells, ≥80% (SDS-PAGE)
Packaging: 5μG
Price: $471
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0921
Product name: AR7
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $478
Updated: 2024/03/01

Cayman Chemical

Product number: 22946
Product name: AR-7
Packaging: 1mg
Price: $32
Updated: 2024/03/01

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AR7 Chemical Properties,Usage,Production

Description

AR7 (80306-38-3) is an atypical retinoid which acts as an RARα antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pathway.1 Downstream signaling results in an increase of LAMP-2A expression.1 Cells pretreated with AR7 had markedly improved viability in a paraquat-induced oxidative stress model.1 AR7 stimulated CMA and attenuated accumulation of SNCA oligomers in prolonged cultures of mutant cortical neurons2 indicating that CMA activation may be a viable disease modifying strategy in Parkinson’s disease3. A targetome analysis of AR7-induced CMA in cancer cells has been performed.4

Uses

AR 7 is a CMA booster. Used in biological study of chemical modulation of chaperone-?mediated autophagy by retinoic acid derivatives.

References

Anguiano et al. (2013), Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives; Nat. Chem. Biol. 9 374 Ho et al. (2020), Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA); Autophagy 16 347 Bonam et al. (2021), Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease; Cells 10 3547 Hao et al. (2019), Targetome analysis of chaperone-mediated autophagy in cancer cells; Autophagy 15 1558

AR7 Preparation Products And Raw materials

Raw materials

Preparation Products

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AR7 Suppliers

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80306-38-3, AR7Related Search:

Tigecycline METHOPRENE ACID N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) Volasertib (BI 6727)

AR7

7-Chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine

7-Chloro-3-p-tolyl-2H-benzo[b][1,4]oxazine

Atypical retinoid 7

Thyroid Hormone receptor,α1 human

c-ERBA-1

ERBA

ERB-T-1

MGC000261

MGC43240

TR, α1, GST tagged human

AR7;AR 7

CS-2649

Reaxys ID: 20039175

2H-1,4-Benzoxazine, 7-chloro-3-(4-methylphenyl)-

AR 7(RARα agonist)

receptor,AR 7,CMA,Retinoid X receptors,Retinoic acid receptors,retinoic,macroautophagy,inhibit,AR-7,AR7,acid,RAR/RXR,Inhibitor

80306-38-3