ChemicalBook > CAS DataBase List > Cilliobrevin D

Cilliobrevin D

Product Name: Cilliobrevin D
CAS No.: 1370554-01-0
Chemical Name: Cilliobrevin D
Synonyms: Cilliobrevin D;Ciliobrevin D, 10 mM in DMSO;Cytoplasmic Dynein Inhibitor, Ciliobrevin D;Benzenepropanenitrile, 2,4-dichloro-α-(7-chloro-3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-β-oxo-;2-(7-Chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile;inhibit,melanosome,spindles,cytoplasmic,γ-tubulin,Inhibitor,dynein,ATPases,Ciliobrevin D,Hedgehog,peroxisomes,aggregation
CBNumber: CB22714664
Molecular Formula: C17H8Cl3N3O2
Formula Weight: 392.62
MOL File: 1370554-01-0.mol

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Cilliobrevin D Property

Boiling point:: 591.8±50.0 °C(Predicted)
Density: 1.537±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 5 mg/mL (12.73 mM; ultrasonic and warming and heat to 80°C)
pka: 5.99±0.20(Predicted)
form: Solid
color: Light yellow to yellow
InChI: InChI=1S/C17H8Cl3N3O2/c18-8-1-3-10(13(20)5-8)15(24)12(7-21)16-22-14-6-9(19)2-4-11(14)17(25)23-16/h1-6,22H,(H,23,25)
InChIKey: JKKSCGHDRHRWOQ-UHFFFAOYSA-N
SMILES: C(=C1NC(=O)C2=CC=C(Cl)C=C2N1)(C#N)C(C1C=CC(Cl)=CC=1Cl)=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 250401
Product name: Cytoplasmic Dynein Inhibitor, Ciliobrevin D
Purity: Ciliobrevin D is a cell-permeable, reversible, and specific blocker of AAA+ ATPase motor cytoplasmic dynein. Disrupts spindle pole focusing and kinetochore-microtubule attachment (~10 to 40 µM).
Packaging: 10 mg
Price: $252
Updated: 2025/07/31

TRC

Product number: C441315
Product name: CiliobrevinD
Packaging: 25mg
Price: $1260
Updated: 2021/12/16

ChemScene

Product number: CS-0087674
Product name: CiliobrevinD
Purity: 98.94%
Packaging: 50mg
Price: $1950
Updated: 2021/12/16

ChemScene

Product number: CS-0087674
Product name: CiliobrevinD
Purity: 98.94%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0087674
Product name: CiliobrevinD
Purity: 98.94%
Packaging: 10mg
Price: $595
Updated: 2021/12/16

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Cilliobrevin D Chemical Properties,Usage,Production

Uses

Ciliobrevin D is an inhibitor of the AAA+ ATPase motor cytoplasmic dynein.

in vivo

Knockdown of Dync1h1 or inactivation of dynein 1 by Ciliobrevin D in the testis in vivo perturbs spermatogenesis. Knockdown of Dync1h1 or the use of Ciliobrevin D to inactivate dynein 1 in the testis in vivo perturbs MT organization through changes in the spatial expression of EB1, perturbs F-actin organization, and perturbs distribution of adhesion protein complexes at the BTB, leading to a loss of BTB integrity. F-actin disorganization in the seminiferous epithelium following Dync1h1 knockdown or dynein 1 inactivation by Ciliobrevin D is mediated by changes in the spatiotemporal expression of actin regulatory proteins Arp3 and Eps8^[3].

Cilliobrevin D Preparation Products And Raw materials

Raw materials

Preparation Products

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1370554-01-0, Cilliobrevin DRelated Search:

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Cilliobrevin D

Cytoplasmic Dynein Inhibitor, Ciliobrevin D

Benzenepropanenitrile, 2,4-dichloro-α-(7-chloro-3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-β-oxo-

inhibit,melanosome,spindles,cytoplasmic,γ-tubulin,Inhibitor,dynein,ATPases,Ciliobrevin D,Hedgehog,peroxisomes,aggregation

2-(7-Chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile

Ciliobrevin D, 10 mM in DMSO

1370554-01-0