ChemicalBook > CAS DataBase List > CPI-169
CPI-169
- Product Name
- CPI-169
- CAS No.
- 1450655-76-1
- Chemical Name
- CPI-169
- Synonyms
- CPI-169;CPI 169;CPI169;CPI-169 racemate;CPI169;CPI 169;CPI-169;CPI-169, EZH2 inhibitor;CPI169 racemate,CPI 169 racemate;1-(1-(1-(Ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide;1H-Indole-3-carboxamide, N-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-1-[1-[1-(ethylsulfonyl)-4-piperidinyl]ethyl]-2-methyl-
- CBNumber
- CB22715621
- Molecular Formula
- C27H36N4O5S
- Formula Weight
- 528.66
- MOL File
- 1450655-76-1.mol
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CPI-169 Property
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥26.45 mg/mL in DMSO; insoluble in H2O; ≥2.18 mg/mL in EtOH with gentle warming and ultrasonic
- form
- solid
- pka
- 11.01±0.10(Predicted)
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 18299
- Product name
- CPI-169
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $68
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 18299
- Product name
- CPI-169
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $235
- Updated
- 2024/03/01
TRC
- Product number
- C781428
- Product name
- CPI-169
- Packaging
- 25mg
- Price
- $800
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-3137
- Product name
- CPI-169racemate
- Purity
- 98.52%
- Packaging
- 5mg
- Price
- $144
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-3137
- Product name
- CPI-169racemate
- Purity
- 98.52%
- Packaging
- 10mg
- Price
- $216
- Updated
- 2021/12/16
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CPI-169 Chemical Properties,Usage,Production
Uses
CPI-169 is a heteroaryl amide that was discovered useful as modulator of Me modifying enzymes.
Definition
ChEBI: 1-[1-(1-ethylsulfonyl-4-piperidinyl)ethyl]-N-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-3-indolecarboxamide is an indolecarboxamide.
Biological Activity
cpi-169 is a novel, small molecule and potent inhibitor of enhancer of zeste homolog 2 (ezh2) with an ic50 value of <1nm for polycomb repressive complex 2 (prc2) [1].cpi-169 has been found to be a potent ezh2 inhibitor with an ic50 value of <1nm for polycomb repressive complex 2 (prc2). in addition, cpi-169 has been reported to reduce cellular levels of histone h3 on lysine 27(h3k27) with an ec50 value of 70nm. moreover, cpi-169 has been exhibited to trigger cell cycle arrest and apoptosis in cells. apart from these, treatment the inhibitor at 200mpk twice daily, cpi-169 has been noted to have a well tolerated in mice with no observed toxic effect or body weight loss [1].
References
[1] vidya balasubramanian, priya iyer, shilpi arora, patrick troyer, emmanuel normant. constellation pharmaceuticals, cambridge, ma. cpi-169, a novel and potent ezh2 inhibitor, synergizes with chop in vivo and achieves complete regression in lymphoma xenograft models
CPI-169 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CPI-169 manufacturers
Career Henan Chemical Co
- Product
- 1-(1-(1-(ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2- methyl-1H-indole-3-carboxamide 1450655-76-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-01-01