Helioxanthin 8-1

Product Name: Helioxanthin 8-1
CAS No.: 840529-13-7
Chemical Name: Helioxanthin 8-1
Synonyms: CS-1213;Helioxanthin 8-1;Helioxanthin analogue 8-1;Helioxanthin 8 1,Helioxanthin 81;11-(1,3-Benzodioxol-5-yl)-8,9-dihydro-1,3-benzodioxolo[4,5-g]phthalazine-7,10-dione;1,3-Benzodioxolo[4,5-g]phthalazine-7,10-dione, 11-(1,3-benzodioxol-5-yl)-8,9-dihydro-
CBNumber: CB22715636
Molecular Formula: C20H12N2O6
Formula Weight: 376.32
MOL File: 840529-13-7.mol

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Helioxanthin 8-1 Property

Melting point:: 318-320 °C
Density: 1.548±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 10.56±0.20(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B4701
Product name: Helioxanthin8-1
Packaging: 2mg
Price: $368
Updated: 2021/12/16

ChemScene

Product number: CS-3198
Product name: Helioxanthin8-1
Purity: >98.0%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ApexBio Technology

Product number: B4701
Product name: Helioxanthin8-1
Packaging: 5mg
Price: $551
Updated: 2021/12/16

ChemScene

Product number: CS-3198
Product name: Helioxanthin8-1
Purity: >98.0%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

ApexBio Technology

Product number: B4701
Product name: Helioxanthin8-1
Packaging: 10mg
Price: $788
Updated: 2021/12/16

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Helioxanthin 8-1 Chemical Properties,Usage,Production

Uses

Helioxanthin 8-1 is an analogue of helioxanthin, exhibites significant in vitro anti-HBV/HCV/HSV-1/HIV activity with EC50 of >5/10/1.4/15 uM. IC50 value: >5/10/1.4/15 uM(HBV/HCV/HSV-1/HIV) [1] Target: Antiviral agent The cyclic hydrazide 28(Helioxanthin 8-1) showed the most potent antiHBV activity among those helioxanthin analogues tested. In addition, compound 28 exhibited moderately potent activity against HIV. It would therefore be promising to study helioxanthin analogues that contain a six-membered ring instead of the five-membered ring found in the lactam [1]. 8-1 exhibited effective inhibition on DHBV replication. The combination of 8-1 with 3TC resulted in additional anti-DHBV activity. Viral induced cells displayed higher susceptibility to 8-1 treatment than non-induced cells. HBV X protein might not be an essential factor in the initiation of the biological activity of 8-1, as demonstrated by its absence in DHBV [2].

Biological Activity

helioxanthin 8-1, an analogue of helioxanthin (ach126447), is an inhibitor of hbv and hiv virus with ec50 values of 0.03 μm and 2.7 μm, respectively [1].helioxanthin 8-1 is the cyclic hydrazide derivative of helioxanthin and has shown significant in vitro antivirus activity with ec50 values of 0.03 μm and 2.7 μm for hbv and hiv, respectively [1]. in the ds-tet5 cells, helioxanthin 8-1 can inhibit duck hepatitis b virus (dhbv) dna synthesis with a mean ic50 value of 0.25±0.05 μm. besides, in induced cells and non-induced ds-tet5 cells, helioxanthin 8-1 has cytotoxic effect with cc50 values of 18±2 μm and 45±3 μm, respectively, by using an mtt assay [2].

References

[1] yeo h1, li y, fu l, zhu jl, gullen ea, dutschman ge, lee y, chung r, huang es, austin dj, cheng yc. synthesis and antiviral activity of helioxanthin analogues. j med chem. 2005 jan 27;48(2):534-46.
[2] ying c1, tan s, cheng yc. helioxanthin analogue 8-1 inhibits duck hepatitis b virus replication in cell culture. antivir chem chemother. 2010;21(2):97-103.

Helioxanthin 8-1 Preparation Products And Raw materials

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Helioxanthin 8-1 Suppliers

China 18 United States 7 Global 25

MedChemexpress LLC

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840529-13-7, Helioxanthin 8-1Related Search:

Helioxanthin derivative 5-4-2

Helioxanthin 8-1

11-(1,3-Benzodioxol-5-yl)-8,9-dihydro-1,3-benzodioxolo[4,5-g]phthalazine-7,10-dione

CS-1213

Helioxanthin analogue 8-1

1,3-Benzodioxolo[4,5-g]phthalazine-7,10-dione, 11-(1,3-benzodioxol-5-yl)-8,9-dihydro-

Helioxanthin 8 1,Helioxanthin 81

840529-13-7