Mutated EGFR-IN-1

Product Name: Mutated EGFR-IN-1
CAS No.: 1421372-66-8
Chemical Name: Mutated EGFR-IN-1
Synonyms: AZD9291 intermediate;OMT-3;CS-1173;HY-78869;AZD9291 3;AZD9291DA;AZD9291 N-2;AZD9291 int-5;Osimertinib N-2;AZD9291 INT1 N-2
CBNumber: CB22715656
Molecular Formula: C25H31N7O
Formula Weight: 445.56
MOL File: 1421372-66-8.mol

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Mutated EGFR-IN-1 Property

Boiling point:: 676.5±65.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: ≥ 75 mg/mL (168.33 mM)
pka: 9.07±0.28(Predicted)
form: Powder
Appearance: Off-white to gray Solid
InChIKey: HTNTZPBKKCORTP-UHFFFAOYSA-N
SMILES: C1(N(CCN(C)C)C)=CC(OC)=C(NC2=NC=CC(C3C4=C(N(C)C=3)C=CC=C4)=N2)C=C1N

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D470923
Product name: N1-[2-(Dimethylamino)ethyl]-5-methoxy-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-1,2,4-benzenetriamine
Packaging: 10mg
Price: $205
Updated: 2021/12/16

ChemScene

Product number: CS-3259
Product name: MutatedEGFR-IN-1
Purity: 99.36%
Packaging: 5g
Price: $400
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611848
Product name: Mutated EGFR-IN-1
Packaging: 10mg
Price: $414.8
Updated: 2021/12/16

AK Scientific

Product number: 0008AP
Product name: N1-[2-(Dimethylamino)ethyl]-5-methoxy-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-1,2,4-benzenetriamine
Packaging: 1mg
Price: $145
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611848
Product name: Mutated EGFR-IN-1
Packaging: 50mg
Price: $674.9
Updated: 2021/12/16

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Mutated EGFR-IN-1 Chemical Properties,Usage,Production

Uses

N1-?[2-?(Dimethylamino)?ethyl]?-?5-?methoxy-?N1-?methyl-?N4-?[4-?(1-?methyl-?1H-?indol-?3-?yl)?-?2-?pyrimidinyl]?-?1,?2,?4-?benzenetriamine can be involved as reactant/reagent in "Schizophrenic" self-assembly of dual thermoresponsive block copolymers bearing a zwitterionic and a non-ionic hydrophilic block.

Synthesis

1421372-67-9

1421372-66-8

Under nitrogen protection, 28.5 g (0.060 mol) of N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-2-nitrobenzene-1,4-diamine was added to 500 mL of methanol with 2.5 g of palladium carbon catalyst. The reaction was stirred at 25 °C for 4 hours in a hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to dryness under reduced pressure to afford 26 g of the brown solid product N1-[2-(dimethylamino)ethyl]-5-methoxy-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-1,2,4-benzenetriamine in 97.3% yield.

IC 50

EGFR^L858R; EGFR^{Exon 19 deletion/T790M}; EGFR^T790M

References

[1] Patent: CN107216313, 2017, A. Location in patent: Paragraph 0058; 0059; 0071; 0072
[2] Patent: CN108129342, 2018, A. Location in patent: Paragraph 0054; 0055; 0056
[3] Patent: CN107188888, 2017, A. Location in patent: Paragraph 0067-0069; 0070-0072
[4] Journal of Heterocyclic Chemistry, 2017, vol. 54, # 5, p. 2898 - 2901
[5] Patent: CN107793413, 2018, A. Location in patent: Paragraph 0180; 0181; 0184; 0185

Mutated EGFR-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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Mutated EGFR-IN-1 Suppliers

China 215 India 6 United States 12 Global 233

Hangzhou Chemtrue Bio-Tech Co.,Ltd.

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SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.

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View Lastest Price from Mutated EGFR-IN-1 manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Mutated EGFR-IN-1 1421372-66-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Henan Fengda Chemical Co., Ltd

Product: Mutated EGFR-IN-1 1421372-66-8
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-09

Zhuozhou Wenxi import and Export Co., Ltd

Product: AZD9291 intermediate 1421372-66-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

1421372-66-8, Mutated EGFR-IN-1Related Search:

Osimertinib mesylate AZD-9291 N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine 1,4-BenzenediaMine, N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]-2-nitro-

Mutated EGFR-IN-1

HY-78869

AZD9291DA HCl salt

N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]benzene-1,2,4-triamine

AZD9291 int-5

N1-[2-(Dimethylamino)ethyl]-5-methoxy-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-1,2,4-benzenetriamine

1,2,4-Benzenetriamine, N1-[2-(dimethylamino)ethyl]-5-methoxy-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-

AZD9291 3

N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine

AZD9291 intermediate 4

AZD9291 INT1 N-2

Osimertinib Impurity 5

CS-1173

AZD91 intermediate

AZD9291 N-2

Mutated EGFR-IN-1 (Osimertinib analog)

N1-[2-(Dimethylamino)ethyl]-5-methoxy-N1-methyl-N4-[4-(1-m-ethyl-1H-indol-3-yl)-2-pyrimidi-nyl]-1,2,

N1-(2-dimethylaminoethyl)-5-methoxy-N1-methyl-N4-[4-(1-methylindol-3-yl)pyrimidin-2-yl]benzene-1,2,4-triamine

N-(2-dimethylamino-ethyl)-2-methoxy-n-methyl-n-[4-(1-methyl-1h-indol-3-yl)-pyrimidin-2-yl]-5-Amino-benzene-1,4-diamine

AZD9291 Intermediate1

Mereletinib Intermediates

OMT-3

N1-(2-(Dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)b

Osimertinib Intermediate 3

AZD9291 intermediates 3

Mutated EGFR inhibitor 1

Osimertinib analog

Osimertinib intermediate

AZD9291 intermediate

N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3- yl)pyrimidin-2-yl)benzene-1,2-triamine

AZD9291DA

N1-(2-(Dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene

1-N-[2-(dimethylamino)ethyl]-5-methoxy-1-N-methyl-4-N-[4-(1-methylindol-3-yl)pyrimidin-2-yl]benzene-1,2,4-triamine

N1- [2- (dimethylamino) ethyl] -5-methoxy-N1- methyl-N4- [4- (1-methyl-1H-indole-3-yl) -2-pyrimidinyl] -1,2,4-phenyltriamine

Osimertinib N-2

N1-[2-(Dimethylamino)ethyl]-5-methoxy-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-1,2,4-

Mutated EGFR-IN-1, 10 mM in DMSO

N1-[2-(Dimethylamino)ethyl]-5-methoxy-N1-methyl-N4-[4-(1-methyl-3-indolyl)-2-pyrimidinyl]-1,2,4-benzenetriamine

Mutated EGFR-IN-1 ，E2251

N1-[2-(dimethylamino)ethyl]-5-methoxy-N1-methyl-N4- [4- (1-methyl-1H-indol-3-yl) -2-pyrimidinyl] -1,2,4-phenyltriamine

1421372-66-8

AZD9291

Pharmaceutical intermediate

API