4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile

Uses

Product Name: 4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile
CAS No.: 906673-45-8
Chemical Name: 4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile
Synonyms: Crisaborole-003;Crisaborole Impurity 31;Crisaborole Impurity 55;Crisaborole Intermediate 1;4-(4-bromo-3-(hydroxymethyl;2-bromo-5-(4-cyanophenoxy)benzyl alcohol;2-Bromo-5-(4-cyanophenoxyl)benzyl alcohol;4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile;Benzonitrile, 4-[4-bromo-3-(hydroxymethyl)phenoxy]-;4-[4-Bromo-3-(hydroxymethyl)phenoxy]benzonitrileQ: What is 4-[4-Bromo-3-(hydroxymethyl)phenoxy]benzonitrile Q: What is the CAS Number of 4-[4-Bromo-3-(hydroxymethyl)phenoxy]benzonitrile Q: What is the storage condition of 4-[4-Bromo-3-(hydroxymethyl)phenoxy]benzonitrile
CBNumber: CB22716062
Molecular Formula: C14H10BrNO2
Formula Weight: 304.14
MOL File: 906673-45-8.mol

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4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile Property

Boiling point:: 447.6±45.0 °C(Predicted)
Density: 1.57±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 13.96±0.10(Predicted)
Appearance: Light yellow to yellow Solid
InChI: InChI=1S/C14H10BrNO2/c15-14-6-5-13(7-11(14)9-17)18-12-3-1-10(8-16)2-4-12/h1-7,17H,9H2
InChIKey: DAMOSKSUIVLOJT-UHFFFAOYSA-N
SMILES: C(#N)C1=CC=C(OC2=CC=C(Br)C(CO)=C2)C=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-B0833
Product name: 4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile
Purity: 97.21%
Packaging: 1g
Price: $83
Updated: 2021/12/16

ChemScene

Product number: CS-B0833
Product name: 4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile
Purity: 97.21%
Packaging: 5g
Price: $178
Updated: 2021/12/16

ChemScene

Product number: CS-B0833
Product name: 4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile
Purity: 97.21%
Packaging: 10g
Price: $337
Updated: 2021/12/16

Ambeed

Product number: A197114
Product name: 4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile
Purity: 97%
Packaging: 100mg
Price: $7
Updated: 2021/12/16

Ambeed

Product number: A197114
Product name: 4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile
Purity: 97%
Packaging: 250mg
Price: $11
Updated: 2021/12/16

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4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile Chemical Properties,Usage,Production

Uses

4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile is a useful research chemical.

Chemical Properties

Class white powder

Synthesis

906673-54-9

906673-45-8

The general procedure for the synthesis of 4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile from 4-(4-bromo-3-formylphenoxy)benzonitrile was as follows: 100 g of 4-(4-bromo-3-formylphenoxy)benzonitrile (VI) was dissolved in 500 mL of methanol at 25-30 °C, and subsequently cooled to 10-15 °C. While maintaining 10-15 °C, 6.2 g of sodium borohydride was slowly added for 60-90 min. After the addition was completed, the temperature of the reaction system was slowly increased to 15-20°C. Upon completion of the reaction, 1000 mL of water was added to the reaction mixture and stirred at 25-30 °C for 1 hour. The resulting solid product was collected by vacuum filtration, washed with water and dried under vacuum at not more than 55 °C to obtain 4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile (V). Yield: 99.0%; purity: 99.02%.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 8, p. 2129 - 2132
[2] Patent: WO2018/207216, 2018, A1. Location in patent: Page/Page column 10
[3] Patent: CN108659024, 2018, A. Location in patent: Paragraph 0038-0039
[4] Patent: WO2018/115362, 2018, A1. Location in patent: Paragraph 0121
[5] Patent: US2007/293457, 2007, A1. Location in patent: Page/Page column 39-40

4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile Suppliers

China 180 Germany 1 India 8 United States 5 Global 194

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View Lastest Price from 4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile manufacturers

Wuhan Biocar Pharmacy CO.,Ltd.

Product: 4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile 906673-45-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 800kg
Release date: 2025-03-18

Henan Aochuang Chemical Co.,Ltd.

Product: 4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile 906673-45-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-16

Shaanxi Dideu New Materials Co. Ltd

Product: 4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile 906673-45-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-22

906673-45-8, 4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrileRelated Search:

4-Bromoaniline BENZAL BROMIDE 4-(4-BroMo-3-(1,3-dioxolan-2-yl)phenoxy)benzonitrile

4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile

2-bromo-5-(4-cyanophenoxy)benzyl alcohol

2-Bromo-5-(4-cyanophenoxyl)benzyl alcohol

Crisaborole Intermediate 1

Benzonitrile, 4-[4-bromo-3-(hydroxymethyl)phenoxy]-

Crisaborole-003

Crisaborole Impurity 31

4-[4-Bromo-3-(hydroxymethyl)phenoxy]benzonitrileQ: What is 4-[4-Bromo-3-(hydroxymethyl)phenoxy]benzonitrile Q: What is the CAS Number of 4-[4-Bromo-3-(hydroxymethyl)phenoxy]benzonitrile Q: What is the storage condition of 4-[4-Bromo-3-(hydroxymethyl)phenoxy]benzonitrile

Crisaborole Impurity 55

4-(4-bromo-3-(hydroxymethyl

906673-45-8