(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione

Product Name: (7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione
CAS No.: 92395-41-0
Chemical Name: (7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione
Synonyms: Amrubicin intermediate;Amrubicin Intermediate 5;Amrubicinhydrochloride int5;9α-amino-9β-acetyl-7,8,9,10-tetrahydro-6,7α,11-trihydroxy-5,12-naphthacenedione;(7S,9S)-9-Acetyl-9-amino-6,7,11-trihydroxy-7,8,9,10-tetrahydro-5,12-tetracenedione;(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione;5,12-Naphthacenedione, 9-acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-, (7S,9S)-
CBNumber: CB22717140
Molecular Formula: C20H17NO6
Formula Weight: 367.35
MOL File: 92395-41-0.mol

More

Less

(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione Property

Melting point:: 158-159℃
Boiling point:: 604.6±55.0 °C(Predicted)
Density: 1.550±0.06 g/cm3(Predicted)
pka: 7.92±0.60(Predicted)

More

Less

Safety

HS Code: 2922500090

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione Chemical Properties,Usage,Production

Uses

(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione can be used as organic synthesis intermediates and pharmaceutical intermediates. It is an intermediate in the synthesis of amrubicin. amrubicin is a third-generation synthetic anthracycline currently in development for the treatment of small cell lung cancer.

Synthesis

A mixture of R-9-acetamido-9- [1,1- (2,2-dimethylpropanedioxy) ethyl] -4,5-dihydro-6,13-dihydroxy -4,14- Methyl-14H-anthraceno [3,2-f] - [1,3] oxazolene-7,12-dione (Compound 4, R = CH3), 1200 g of 3N sulfuric acid aqueous solution and incubated at 60-70 ?? C for 8 hours. The pH of the solution was adjusted to 7-8 with aqueous sodium hydrogencarbonate solution, The combined chloroform layers were washed with water, dried, filtered and concentrated. The residue was stirred with isopropyl ether to give (+) - 9-amino-4-demethoxy-9-deoxo daunomycinone.

(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione Suppliers

China 14 Global 14

Wuhan EEChem Technologies Co., Ltd

Tel: 0711-3617768 13308685235
Fax: 0711-3616558
Email: lihongcai4360@sina.com
Country: China
ProdList: 1383
Advantage: 55

Abydos Scientific

Tel: 025-84767922 18936879710
Email: sales@abydoscientific.com
Country: China
ProdList: 1008
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

Speranza Chemical Co., Ltd.

Tel: 0755-21030354 18126410231
Email: sales@speranzachem.com
Country: China
ProdList: 511
Advantage: 58

Changzhou Bojia Biomedical Technology Co., Ltd.

Tel: 2122619822
Email: czbjpharma@126.com
Country: China
ProdList: 18478
Advantage: 58

WEITIXIHAUGONG

Tel: 0371-53370800 18037197114
Email: 2853031799@qq.com
Country: China
ProdList: 9993
Advantage: 58

Shaanxi Didu New Material Co., Ltd

Tel: 029-81145920 15353716720
Email: 1046@dideu.com
Country: China
ProdList: 9987
Advantage: 58

Shandong Mopai Biotechnology Co., Ltd

Tel: 13070690626
Email: admin@mopaikeji.com
Country: China
ProdList: 10757
Advantage: 58

Wuhan Noble Pharmaceutical&Chemical Co.Ltd.

Tel: 027-87827088 13907152521
Email: 3085654926@QQ.COM
Country: China
ProdList: 1972
Advantage: 58

Hubei Soren Technology Co., Ltd

Tel: 0-13419562052 13419562052
Email: wwmlyb@163.com
Country: China
ProdList: 2860
Advantage: 58

Hebei Weibang Biotechnology Co., Ltd

Tel: +8617732866630
Email: bess@weibangbio.com
Country: China
ProdList: 18152
Advantage: 58

Zibo Hangyu Biotechnology Development Co., Ltd

Tel: +86-0533-2185556 +8617865335152
Email: Mandy@hangyubiotech.com
Country: China
ProdList: 10986
Advantage: 58

Speranza Chemical Co., Ltd.

Tel: +86-86-075521030354 +8618688942810
Fax: +86-755-33122716
Email: sophieliu@speranzachem.com
Country: China
ProdList: 802
Advantage: 55

Sense Chemicals (Shanghai) Co., Ltd.

Tel: +86-21-52751036; +8613818977689
Fax: +86-21-52751036
Email: david.dai@sensechemicals.com
Country: China
ProdList: 225
Advantage: 58

92395-41-0, (7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedioneRelated Search:

(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione

Amrubicinhydrochloride int5

5,12-Naphthacenedione, 9-acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-, (7S,9S)-

9α-amino-9β-acetyl-7,8,9,10-tetrahydro-6,7α,11-trihydroxy-5,12-naphthacenedione

Amrubicin intermediate

Amrubicin Intermediate 5

(7S,9S)-9-Acetyl-9-amino-6,7,11-trihydroxy-7,8,9,10-tetrahydro-5,12-tetracenedione

92395-41-0