ChemicalBook > CAS DataBase List > 4-chloro-N-ethyl-5-(trifluoroMethyl)pyriMidin-2-aMine

4-chloro-N-ethyl-5-(trifluoroMethyl)pyriMidin-2-aMine

Product Name
4-chloro-N-ethyl-5-(trifluoroMethyl)pyriMidin-2-aMine
CAS No.
1374829-47-6
Chemical Name
4-chloro-N-ethyl-5-(trifluoroMethyl)pyriMidin-2-aMine
Synonyms
2-chloro-N-ethyl-5-(trifluoromethyl)pyrimidin-4-amine;2-chloro-N-ethyl-5-(trifluoromethyl)-4-Pyrimidinamine;4-chloro-N-ethyl-5-(trifluoroMethyl)pyriMidin-2-aMine;2-chloro-4-(ethylamino)-5-(trifluoromethyl)pyrimidine;(2-Chloro-5-trifluoromethyl-pyrimidin-4-yl)-ethyl-amine;4-Pyrimidinamine, 2-chloro-N-ethyl-5-(trifluoromethyl)-
CBNumber
CB22721116
Molecular Formula
C7H7ClF3N3
Formula Weight
225.6
MOL File
1374829-47-6.mol
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4-chloro-N-ethyl-5-(trifluoroMethyl)pyriMidin-2-aMine Property

Boiling point:
319.1±42.0 °C(Predicted)
Density 
1.434±0.06 g/cm3(Predicted)
pka
0.63±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Crysdot
Product number
CD11269704
Product name
4-Chloro-N-ethyl-5-(trifluoromethyl)pyrimidin-2-amine
Purity
95+%
Packaging
250mg
Price
$262
Updated
2021/12/16
Chemenu
Product number
CM166180
Product name
4-Chloro-N-ethyl-5-(trifluoromethyl)pyrimidin-2-amine
Purity
95%
Packaging
1g
Price
$611
Updated
2021/12/16
Crysdot
Product number
CD11269704
Product name
4-Chloro-N-ethyl-5-(trifluoromethyl)pyrimidin-2-amine
Purity
95+%
Packaging
1g
Price
$654
Updated
2021/12/16
Chemenu
Product number
CM166180
Product name
4-Chloro-N-ethyl-5-(trifluoromethyl)pyrimidin-2-amine
Purity
95%
Packaging
5g
Price
$1834
Updated
2021/12/16
Crysdot
Product number
CD11269704
Product name
4-Chloro-N-ethyl-5-(trifluoromethyl)pyrimidin-2-amine
Purity
95+%
Packaging
5g
Price
$1961
Updated
2021/12/16
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4-chloro-N-ethyl-5-(trifluoroMethyl)pyriMidin-2-aMine Chemical Properties,Usage,Production

Synthesis

A solution of 2,4-dichloro-5-(trifluoromethyl)pyrimidine (70 g, 322.61 mmol) in THF (1.4 L) was treated with a solution of ethanolamine (32 g, 709.74 mmol, 46.37 mL) in THF (100 mL) at 0°C, dropwise under N2, over 1 hour. Once the addition was complete, the mixture was stirred at 25°C for 1 hour. The mixture was then filtered and concentrated under reduced pressure to obtain a residue. The residue was subsequently triturated with DCM (200 mL) and filtered. The filtrate was recrystallized with a mixture of n-heptane (600 mL) and MTBE (400 mL). The resulting phase was syrup-like in consistency, and the liquid phase was discarded. The syrup residue was further purified by silica gel column chromatography (PE: EtOAc=20:1) to yield 4-chloro-N-ethyl-5-(trifluoromethyl) pyrimidine-2-amine as a white solid.

4-chloro-N-ethyl-5-(trifluoroMethyl)pyriMidin-2-aMine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-chloro-N-ethyl-5-(trifluoroMethyl)pyriMidin-2-aMine Suppliers

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1374829-47-6, 4-chloro-N-ethyl-5-(trifluoroMethyl)pyriMidin-2-aMineRelated Search:

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