Ningetinib Tosylate

Product Name: Ningetinib Tosylate
CAS No.: 1394820-77-9
Chemical Name: Ningetinib Tosylate
Synonyms: 112176;CT-053;CT-053 tosylate;Ningetinib (Tosylate);Ningetinib-Tosylate(tosylate);Ningetinib Tosylate, 10 mM in DMSO;Ningetinib Tosylate (CT-053 Tosylate);N-(3-Fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-ph;VEGFR,c-Met/HGFR,Inhibitor,TAM Receptor,Tyro3,inhibit,Axl,Vascular endothelial growth factor receptor,Ningetinib,Ningetinib Tosylate,Mer;N-(3-fluoro-4-((7-(2-hydroxy-2-Methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-diMethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxaMide p-toluenesulfonate
CBNumber: CB22723675
Molecular Formula: C38H37FN4O8S
Formula Weight: 728.7857832
MOL File: 1394820-77-9.mol

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Ningetinib Tosylate Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO: 33.33 mg/mL (45.73 mM); Water: < 0.1 mg/mL (insoluble)
form: Solid
color: White to off-white
InChIKey: NAUYISNCVNUUDK-UHFFFAOYSA-N
SMILES: N1(C)C(C)=C(C(NC2=CC=C(OC3=C4C(=NC=C3)C=C(OCC(O)(C)C)C=C4)C(F)=C2)=O)C(=O)N1C1=CC=CC=C1.C1(S(O)(=O)=O)=CC=C(C)C=C1

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0027426
Product name: NingetinibTosylate
Purity: 99.92%
Packaging: 5mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-0027426
Product name: NingetinibTosylate
Purity: 99.92%
Packaging: 10mg
Price: $160
Updated: 2021/12/16

Apolloscientific

Product number: BISN0068
Product name: NingetinibTosylate
Purity: 99%
Packaging: 5mg
Price: $211
Updated: 2021/12/16

ChemScene

Product number: CS-0027426
Product name: NingetinibTosylate
Purity: 99.92%
Packaging: 25mg
Price: $300
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BN168496
Product name: Ningetinib tosylate
Packaging: 25mg
Price: $425
Updated: 2021/12/16

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Ningetinib Tosylate Chemical Properties,Usage,Production

Uses

Ningetinib Tosylate is a potent, orally bioavailable small molecule tyrosine kinase inhibitor (TKI) with IC50s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively.

in vivo

When single dosed orally (3 mg/kg) to U87MG tumor-bearing nude mice, Ningetinib Tosylate (CT053PTSA) potently inhibits the phosphorylation of c-Met and its downstream signaling kinases AKT and ERK1/2 for up to 6 hours in tumor tissues. In orthotopic U87MG human glioblastoma xenograft model, Ningetinib Tosylate prolongs the median survival time (MST) and yields significant increase in life-span value (ILS=32%, p=0.003) at an oral dose of 20 mg/kg/day (dosed 21 days) versus the vehicle-treated group^[1].

IC 50

Axl; VEGFR2: 1.9 nM (IC₅₀)

References

[1] Ning Xi, et al. Abstract 1755: CT053PTSA, a novel c-MET and VEGFR2 inhibitor, potently suppresses angiogenesis and tumor growth. Cancer Res 2014;74(19 Suppl):Abstract nr 1755.

Ningetinib Tosylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ningetinib Tosylate Suppliers

China 38 India 1 United States 3 Global 42

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1394820-77-9, Ningetinib TosylateRelated Search:

N-(3-fluoro-4-((7-(2-hydroxy-2-Methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-diMethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxaMide p-toluenesulfonate

N-(3-Fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-ph

Ningetinib (Tosylate)

N-(3-fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide 4-methylbenzenesulfonate

Ningetinib Tosylate (CT-053 Tosylate)

CT-053 tosylate

Ningetinib-Tosylate(tosylate)

CT-053

112176

1H-Pyrazole-4-carboxamide, N-[3-fluoro-4-[[7-(2-hydroxy-2-methylpropoxy)-4-quinolinyl]oxy]phenyl]-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-, 4- methylbenzenesulfonate (1:1)

VEGFR,c-Met/HGFR,Inhibitor,TAM Receptor,Tyro3,inhibit,Axl,Vascular endothelial growth factor receptor,Ningetinib,Ningetinib Tosylate,Mer

Ningetinib Tosylate, 10 mM in DMSO

1394820-77-9

C38H37FN4O8S