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N-(2-AMINO-4-TRIFLUOROMETHYLPHENYL)PIPERIDINE

Product Name
N-(2-AMINO-4-TRIFLUOROMETHYLPHENYL)PIPERIDINE
CAS No.
1496-40-8
Chemical Name
N-(2-AMINO-4-TRIFLUOROMETHYLPHENYL)PIPERIDINE
Synonyms
AKOS B025581;AKOS BB-8562;ASISCHEM Z43511;BUTTPARK 44\09-69;ART-CHEM-BB B025581;3-AMINO-4-PIPERIDINOBENZOTRIFLUORIDE;2-piperidino-5-(trifluoromethyl)aniline;3-AMINO-4-(1-PIPERIDINO)BENZOTRIFLUORIDE;2-PIPERIDIN-1-YL-5-(TRIFLUOROMETHYL)ANILINE;2-(1-Piperidinyl)-5-(trifluoromethyl)aniline
CBNumber
CB2272441
Molecular Formula
C12H15F3N2
Formula Weight
244.26
MOL File
1496-40-8.mol
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N-(2-AMINO-4-TRIFLUOROMETHYLPHENYL)PIPERIDINE Property

Melting point:
41 °C
Boiling point:
332.2±42.0 °C(Predicted)
Density 
1.236±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
6.19±0.11(Predicted)
Appearance
Off-white to light brown Solid
CAS DataBase Reference
1496-40-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
HazardClass 
6.1
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
P992233
Product name
2-(Piperidin-1-yl)-5-(trifluoromethyl)aniline
Packaging
500mg
Price
$110
Updated
2021/12/16
Apolloscientific
Product number
PC1100E
Product name
2-(Piperidin-1-yl)-5-(trifluoromethyl)aniline
Purity
97%
Packaging
1g
Price
$32
Updated
2021/12/16
AK Scientific
Product number
1692CD
Product name
2-(Piperidin-1-yl)-5-(trifluoromethyl)aniline
Packaging
5g
Price
$371
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0020203
Product name
2-PIPERIDINO-5-(TRIFLUOROMETHYL)ANILINE
Purity
95.00%
Packaging
1G
Price
$648.81
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0020203
Product name
2-PIPERIDINO-5-(TRIFLUOROMETHYL)ANILINE
Purity
95.00%
Packaging
2.5G
Price
$852.21
Updated
2021/12/16
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N-(2-AMINO-4-TRIFLUOROMETHYLPHENYL)PIPERIDINE Chemical Properties,Usage,Production

Synthesis

1692-79-1

1496-40-8

To a solution of methanol (10 ml) containing 1-(2-nitro-4-(trifluoromethyl)phenyl)piperidine (559 mg, 2.03 mmol) was sequentially added concentrated hydrochloric acid (2.00 ml, 24.0 mmol) and anhydrous stannous dichloride (2.50 g, 13.1 mmol) at 0 °C. The reaction mixture was gradually warmed up to room temperature with continuous stirring for 17.5 hours. Upon completion of the reaction, saturated aqueous sodium bicarbonate solution was added to the mixture for neutralization. Subsequently, the mixture was extracted three times with ethyl acetate. The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (50 g silica gel, eluent hexane/ethyl acetate = 14/1) to afford 2-piperidin-1-yl-5-(trifluoromethyl)aniline (448 mg, 1.83 mmol, 90.4% yield) as a light yellow solid. The product was characterized by TLC and 1H NMR (CDCl3, 400 MHz): TLC Rf 0.30 (unfolding agent hexane/acetone=18/1); 1H NMR (CDCl3, 400 MHz) δ 1.59-1.60 (m, 2H, CH2), 1.71 (tt, 4H, J=5.4,5.4Hz, 2CH2), 2.85 ( brs, 4H, 2CH2), 4.09 (brs, 2H, NH2), 6.92 (d, 1H, J=1.9Hz, aromatic-H), 6.97 (dd, 1H, J=1.9,8.4Hz, aromatic-H), 7.01 (d, 1H, J=8.4Hz, aromatic-H).

References

[1] Patent: EP1712242, 2006, A1. Location in patent: Page/Page column 18; 30
[2] Patent: EP1712242, 2006, A1. Location in patent: Page/Page column 18; 31
[3] Patent: EP2279750, 2011, A1
[4] European Journal of Medicinal Chemistry, 2017, vol. 134, p. 97 - 109
[5] Journal of Medicinal Chemistry, 2007, vol. 50, # 4, p. 627 - 640

N-(2-AMINO-4-TRIFLUOROMETHYLPHENYL)PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2-AMINO-4-TRIFLUOROMETHYLPHENYL)PIPERIDINE Suppliers

China 44 France 1 Germany 3 India 3 Russia 1 Ukraine 1 United Kingdom 10 United States 14 Global 77
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
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62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
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Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
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61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
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56
Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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China
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18207
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66
Shanghai Ennopharm Co., Ltd.
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+86 (21) 6435-5022
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China
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4267
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Yancheng Orgunion Pharmaceutical Sci & Tech Co., Ltd.
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0515-89701588 13770166955
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0515-87400189
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orgunion@orgunion.com
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China
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620
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Chengdu Research Accelerators Technology Co., Ltd.
Tel
028-64353063
Fax
028-64353063 QQ:784253935
Email
reacchemical@163.com
Country
China
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5253
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Wuhan Chemwish Technology Co.， Ltd
Tel
027-67849912
Fax
027-87531808
Email
sales@chemwish.com
Country
China
ProdList
9148
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60
Changzhou Hopschain Chemical Co.,Ltd.
Tel
0519-85528066 13775048983
Fax
0519-85528066
Email
sales@hopschem.com
Country
China
ProdList
31553
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1496-40-8, N-(2-AMINO-4-TRIFLUOROMETHYLPHENYL)PIPERIDINERelated Search:

N-(2-AMINO-4-TRIFLUOROMETHYLPHENYL)PIPERIDINE Benzotrifluoride N-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]PIPERIDINE 1-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]PIPERIDINE-4-CARBOXAMIDE ETHYL 1-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]PIPERIDINE-3-CARBOXYLATE ETHYL 1-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]PIPERIDINE-4-CARBOXYLATE 1-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]TETRAHYDRO-4(1H)-PYRIDINONE 4-METHYL-1-(4-AMINO-2-TRIFLUOROMETHYLPHENYL)PIPERIDINE DIHYDROCHLORIDE N-[(3-ACETYL-4,5-DIHYDRO-5-ISOXAZOLYL)METHYL]-1-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINECARBOXAMIDE 1-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]-4-(3-(1-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDYL)PROPYL)PIPERIDINE DIETHYL 2-(2-(1-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINYLIDENE)HYDRAZINO)-6-HYDROXY-3,5-PYRIDINEDICARBOXYLATE N-ALLYL-1-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINECARBOXAMIDE (8-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]-3-PHENYL-1-OXA-4,8-DIAZASPIRO[4.5]DEC-4-YL)(4-FLUOROPHENYL)METHANONE METHYL 1-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINECARBOXYLATE 1-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]-N-([3-(4-METHOXYPHENYL)-2-METHYLTETRAHYDRO-5-ISOXAZOLYL]METHYL)-4-PIPERIDINECARBOXAMIDE 1-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINECARBOXYLIC ACID 8-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]-N-(4-METHYLPHENYL)-3-PHENYL-1-OXA-4,8-DIAZASPIRO[4.5]DECANE-4-CARBOXAMIDE 4,5-BIS(HYDROXYMETHYL)-3-HYDRAZIDO-4,5-DIHYDROISOXAZOLE-1(2,6-DINITRO-4-TRIFLUOROMETHYLPHENYL)PIPERID-4-ONE ACETAL

  • BUTTPARK 44\09-69
  • ART-CHEM-BB B025581
  • ASISCHEM Z43511
  • 2-PIPERIDIN-1-YL-5-(TRIFLUOROMETHYL)ANILINE
  • 2-PIPERIDIN-1-YL-5-TRIFLUOROMETHYL-PHENYLAMINE
  • AKOS BB-8562
  • AKOS B025581
  • N-(2-AMINO-4-TRIFLUOROMETHYLPHENYL)PIPERIDINE
  • 2-piperidino-5-(trifluoromethyl)aniline
  • 3-AMINO-4-(1-PIPERIDINO)BENZOTRIFLUORIDE
  • 3-AMINO-4-PIPERIDINOBENZOTRIFLUORIDE
  • 2-(1-Piperidinyl)-5-(trifluoromethyl)aniline
  • 1-[2-Amino-4-(trifluoromethyl)phenyl]piperidine, 3-Amino-4-(piperidin-1-yl)benzotrifluoride
  • 2-(Piperidin-1-yl)-5-(trifluoromethyl)aniline 97%
  • 2-(piperidin-1-yl)-5-(trifluoromethyl)benzenamine
  • 2-(Piperidin-1-yl)-5-(trifluoromethyl)aniline97%
  • 4-(piperidin-1-yl)-3-(trifluoromethyl)aniline
  • Benzenamine, 2-(1-piperidinyl)-5-(trifluoromethyl)-
  • 1496-40-8
  • C12H15F3N2
  • Piperidine