7-AMINO-1,8-NAPHTHYRIDIN-2(8H)-ONE
Uses- Product Name
- 7-AMINO-1,8-NAPHTHYRIDIN-2(8H)-ONE
- CAS No.
- 1931-44-8
- Chemical Name
- 7-AMINO-1,8-NAPHTHYRIDIN-2(8H)-ONE
- Synonyms
- SURI-002;7-AMINO-1,8-NAPHTHYRIDIN-2-OL;2-AMino-1,8-naphthyridin-7-ol;7-AMino-1,8-naphthyridin-2-one;7-Amino-1,8-naphthyridine-2-ol;7-Amino-8H-1,8-naphthyridin-2-one;7-AMINO-1,8-NAPHTHYRIDIN-2(8H)-ONE;7-Amino-1H-[1,8]naphthyridin-2-one;7-amino-1,8-naphthyridin-2(1H)-one;2-AMINO-7-HYDROXY-1,8-NAPHTHYRIDINE
- CBNumber
- CB2272496
- Molecular Formula
- C8H7N3O
- Formula Weight
- 161.16
- MOL File
- 1931-44-8.mol
7-AMINO-1,8-NAPHTHYRIDIN-2(8H)-ONE Property
- Melting point:
- >335°C (dec.)
- Boiling point:
- 415.6±38.0 °C(Predicted)
- Density
- 1.49±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Methanol (Slightly, Heated)
- form
- Solid
- pka
- 3.39±0.20(Predicted)
- color
- Dark Yellow to Yellow-Brown
- InChI
- InChI=1S/C8H7N3O/c9-6-3-1-5-2-4-7(12)11-8(5)10-6/h1-4H,(H3,9,10,11,12)
- InChIKey
- NSPQTGOJGZXAJM-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC=C(N)N=2)C=CC1=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- A611635
- Product name
- 2-Amino-7-hydroxy-1,8-naphthridine
- Packaging
- 2g
- Price
- $240
- Updated
- 2021/12/16
- Product number
- CHM0166460
- Product name
- 7-AMINO-1,8-NAPHTHYRIDIN-2(8H)-ONE
- Purity
- 98.00%
- Packaging
- 1G
- Price
- $721.88
- Updated
- 2021/12/16
- Product number
- 2980BB
- Product name
- 7-Amino-1,8-naphthyridin-2(1H)-one
- Packaging
- 25g
- Price
- $884
- Updated
- 2021/12/16
- Product number
- FA17670
- Product name
- 2-Amino-7-hydroxy-1,8-naphthridine
- Packaging
- 5G
- Price
- $905
- Updated
- 2021/12/16
- Product number
- CHM0166460
- Product name
- 7-AMINO-1,8-NAPHTHYRIDIN-2(8H)-ONE
- Purity
- 98.00%
- Packaging
- 10G
- Price
- $2194.5
- Updated
- 2021/12/16
7-AMINO-1,8-NAPHTHYRIDIN-2(8H)-ONE Chemical Properties,Usage,Production
Uses
2-Amino-7-hydroxy-1,8-naphthidine is used as a research compound and in organic synthesis, etc.
Chemical Properties
Yellow-Brown Solid
Synthesis
141-86-6
617-48-1
1931-44-8
2,6-diaminopyridine (20 g, 0.18 mol) and DL-malic acid (27 g, 0.2 mol) were used as raw materials in a 500 mL three-necked round-bottomed flask equipped with a dosing funnel, thermometer and mechanical stirrer. The mixture was cooled in an ice-water bath, and concentrated sulfuric acid (100 mL) was added slowly dropwise, with the rate of dropwise acceleration controlled to keep the reaction temperature from exceeding 45 °C. Subsequently, the addition funnel was replaced with a reflux condenser and the reaction mixture was heated to 110°C and maintained for 3 hours. Upon completion of the reaction, the solution was transferred to a 1 L beaker, cooled to 0 °C via an ice-water bath, and adjusted to pH=8 by slowly adding aqueous NH4OH (300 mL).The crude product was collected by vacuum filtration and the filter cake was washed with 2 L of water. The solid product was ground with a 1:9 (v:v) water:methanol mixture and collected again by vacuum filtration to afford 7-amino-2-hydroxy-1,8-diazanaphthalene as a tan powder in 25 g (86% yield). The product was structurally confirmed by 1H NMR (500 MHz, DMSO-d6) and 13C NMR (126 MHz, DMSO-d6) as well as mass spectrometry (ESI, CH3OH).
References
[1] Journal of Organic Chemistry, 1981, vol. 46, # 5, p. 833 - 839
[2] Organic and Biomolecular Chemistry, 2012, vol. 10, # 13, p. 2578 - 2589
[3] Organic and Biomolecular Chemistry, 2012, vol. 10, # 25, p. 4899 - 4906
[4] Organic and Biomolecular Chemistry, 2012, vol. 10, # 1, p. 90 - 95
[5] Organic and Biomolecular Chemistry, 2014, vol. 12, # 33, p. 6500 - 6506
7-AMINO-1,8-NAPHTHYRIDIN-2(8H)-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
7-AMINO-1,8-NAPHTHYRIDIN-2(8H)-ONE Suppliers
- Tel
- 028-65791793 18140026355
- Fax
- QQ568470422
- 568470422@qq.com
- Country
- China
- ProdList
- 9997
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 13761627472
- Fax
- 86-21-64965863
- 183009664@qq.com
- Country
- China
- ProdList
- 649
- Advantage
- 62
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9895
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 15121041756
- xingui2022@126.com
- Country
- China
- ProdList
- 9979
- Advantage
- 58
- Tel
- 13764913901
- Fax
- -
- info@angtibio.com
- Country
- China
- ProdList
- 4985
- Advantage
- 55
- Tel
- 13951936332 18305166317
- Fax
- -
- info@serpharm.com
- Country
- China
- ProdList
- 493
- Advantage
- 55
- Tel
- 021-64502386 18017349250
- shsynchem@gmail.com
- Country
- China
- ProdList
- 296
- Advantage
- 60