BI-224436

Product Name: BI-224436
CAS No.: 1155419-89-8
Chemical Name: BI-224436
Synonyms: BI-224436;BI 224436;3-Quinolineacetic acid, 4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-α-(1,1-dimethylethoxy)-2-methyl-, (αS,4R)-
CBNumber: CB22729354
Molecular Formula: C27H26N2O4
Formula Weight: 442.51
MOL File: 1155419-89-8.mol

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BI-224436 Property

Boiling point:: 631.8±55.0 °C(Predicted)
Density: 1.277±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C,unstable in solution, ready to use.
solubility: DMSO: ≥ 50 mg/mL (112.99 mM)
pka: 0.81±0.30(Predicted)
form: Powder
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-3472
Product name: BI224436
Purity: 98.17%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-3472
Product name: BI224436
Purity: 98.17%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611778
Product name: BI-224436
Packaging: 10mg
Price: $615.4
Updated: 2021/12/16

ChemScene

Product number: CS-3472
Product name: BI224436
Purity: 98.17%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611778
Product name: BI-224436
Packaging: 50mg
Price: $1802
Updated: 2021/12/16

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BI-224436 Chemical Properties,Usage,Production

Uses

BI 224436 is a novel HIV-1 noncatalytic site integrase inhibitor with EC50 values of less than 15 nM against different HIV-1 laboratory strains.

in vivo

BI 224436 exhibits excellent pharmacokinetic profiles in rat (clearance as a percentage of hepatic flow [CL], 0.7%; bioavailability [F], 54%), monkey (CL, 23%; F, 82%), and dog (CL, 8%; F, 81%)^[1].

References

[1] Fenwick C, et al. Preclinical profile of BI 224436, a novel HIV-1 non-catalytic-site integrase inhibitor. Antimicrob Agents Chemother. 2014 Jun;58(6):3233-44. DOI:10.1128/AAC.02719-13

BI-224436 Preparation Products And Raw materials

Raw materials

Preparation Products

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BI-224436 Suppliers

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1155419-89-8, BI-224436Related Search:

BI 224436

BI-224436

3-Quinolineacetic acid, 4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-α-(1,1-dimethylethoxy)-2-methyl-, (αS,4R)-

1155419-89-8