ChemicalBook > CAS DataBase List > RDEA-594 sodiuM

RDEA-594 sodiuM

Product Name: RDEA-594 sodiuM
CAS No.: 1151516-14-1
Chemical Name: RDEA-594 sodiuM
Synonyms: CS-651;RDEA-594 sodiuM;Lesinurad sodiuM;Pentanedioicacid,5-oxo-,diethylester;sodium 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetate;Sodium 2-((5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3- yl)sulfanyl)acetate;Acetic acid, 2-((5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl)thio)-, sodium salt;Acetic acid, 2-[[5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-, sodium salt (1:1)
CBNumber: CB22729369
Molecular Formula: C17H13BrN3O2S.Na
Formula Weight: 426.26279
MOL File: 1151516-14-1.mol

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RDEA-594 sodiuM Property

storage temp.: Store at -20°C
solubility: DMSO:55.5(Max Conc. mg/mL);137.97(Max Conc. mM)
Ethanol:85.0(Max Conc. mg/mL);199.41(Max Conc. mM)
Water:8.0(Max Conc. mg/mL);18.77(Max Conc. mM)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-3478
Product name: Lesinuradsodium
Purity: 99.96%
Packaging: 5mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-3478
Product name: Lesinuradsodium
Purity: 99.96%
Packaging: 10mg
Price: $84
Updated: 2021/12/16

ChemScene

Product number: CS-3478
Product name: Lesinuradsodium
Purity: 99.96%
Packaging: 50mg
Price: $228
Updated: 2021/12/16

ChemScene

Product number: CS-3478
Product name: Lesinuradsodium
Purity: 99.96%
Packaging: 100mg
Price: $312
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0004804
Product name: LESINURAD SODIUM
Purity: 95.00%
Packaging: 5MG
Price: $503.09
Updated: 2021/12/16

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RDEA-594 sodiuM Chemical Properties,Usage,Production

Uses

Lesinurad sodium is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 μM, respectively.

in vivo

Lesinurad (RDEA594) shows better pharmacokinetics than its pro-drug RDEA806. The 100 mg dose of Lesinurad exhibits a phamacological effect in the range of that produced by 300 mg to 800 mg single doses of RDEA806^[3].

References

[1] Shen Z, et al. In Vitro and In Vivo Interaction Studies Between Lesinurad, a Selective Urate Reabsorption Inhibitor, and Major Liver or Kidney Transporters. Clin Drug Investig. 2016 Jun;36(6):443-52 DOI:10.1037//0882-7974.4.4.471
[2] Sattui SE, et al. Treatment of hyperuricemia in gout: current therapeutic options, latest developments and clinical implications. Ther Adv Musculoskelet Dis. 2016 Aug;8(4):145-59. DOI:10.1177/1759720X16646703
[3] L.Yeh, et al. RDEA594, a potential uric acid lowering agent througn inhibition of uric acid reuptake ,shows better pharmacokinetics rhan its prodrug RDEA806. 2008 ACR/ARHP Annual Scientific Meeting, 24-29 October 2008, USA.

RDEA-594 sodiuM Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from RDEA-594 sodiuM manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Lesinurad Sodium 1151516-14-1
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-08-02

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Lesinurad Sodium. 1151516-14-1
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2025-01-07

Career Henan Chemical Co

Product: RDEA-594 sodiuM 1151516-14-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2020-03-05

1151516-14-1, RDEA-594 sodiuMRelated Search:

Lesinurad sodiuM

RDEA-594 sodiuM

Acetic acid, 2-[[5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-, sodium salt (1:1)

sodium 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetate

Acetic acid, 2-((5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl)thio)-, sodium salt

Sodium 2-((5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3- yl)sulfanyl)acetate

CS-651

Pentanedioicacid,5-oxo-,diethylester

1151516-14-1

C17H13BrN3NaO2S

C17H13BrN3O2SNa