AZD-3965

ChemicalBook > CAS DataBase List > AZD-3965

Product Name: AZD-3965
CAS No.: 733809-45-5
Chemical Name: AZD-3965
Synonyms: AZD-3965;(S)-5-(4-hydroxy-4-methylisoxazolidine-2-carbonyl)-1-isopropyl-3-methyl-6-((3-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione;5-[[(4S)-4-Hydroxy-4-methyl-2-isoxazolidinyl]carbonyl]-3-methyl-1-(1-methylethyl)-6-[[3-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione;Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5-[[(4S)-4-hydroxy-4-methyl-2-isoxazolidinyl]carbonyl]-3-methyl-1-(1-methylethyl)-6-[[3-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]-
CBNumber: CB22731018
Molecular Formula: C21H24F3N5O5S
Formula Weight: 515.51
MOL File: 733809-45-5.mol

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AZD-3965 Property

Melting point:: >140°C (dec.)
Boiling point:: 723.1±70.0 °C(Predicted)
Density: 1.483±0.06 g/cm3(Predicted)
storage temp.: -20°C, Inert atmosphere
solubility: DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form: Solid
pka: 10.92±0.50(Predicted)
color: Off-White to Pale Yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A965308
Product name: AZD-3965
Packaging: 10mg
Price: $185
Updated: 2021/12/16

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AZD-3965 Chemical Properties,Usage,Production

Uses

AZD 3965 is a monocarboxylate transporter 1 (MCT1) inhibitor.

Enzyme inhibitor

This orally bioavailable MCT1 inhibitor (FW = 515.51 g/mol; CASs = 733809-45-5 and 1448671-31-5), also named (S)-5-(4-hydroxy-4- methylisoxazolidine-2-carbonyl)-1-isopropyl-3-methyl-6-((3-methyl-5-(tri fluoromethyl)-1H-pyrazol-4-yl)methyl)-thieno[2,3-d]pyrimidine-2,4(1H, 3H) -dione, selectively targets the Monocarboxylate Transporter-1 (IC50 = 1.6 nM) and is ~6x less active toward MCT2. AZD3965 does not inhibit MCT4, even at 10 μM. MCT1 and MCT4 are primarily involved in lactate transport, targeting highly glycolytic cancer cells, especially those that are hypoxic. The latter property suggests that the combined use with a vascular-disrupting anticancer agent (such as combrestatin) may improve the inhibitory action of AZD-3965 against cancer cells.

AZD-3965 Preparation Products And Raw materials

Raw materials

Preparation Products

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733809-45-5, AZD-3965Related Search:

GSK-2126458

AZD-3965

5-[[(4S)-4-Hydroxy-4-methyl-2-isoxazolidinyl]carbonyl]-3-methyl-1-(1-methylethyl)-6-[[3-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

(S)-5-(4-hydroxy-4-methylisoxazolidine-2-carbonyl)-1-isopropyl-3-methyl-6-((3-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5-[[(4S)-4-hydroxy-4-methyl-2-isoxazolidinyl]carbonyl]-3-methyl-1-(1-methylethyl)-6-[[3-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]-

733809-45-5

C21H24F3N5O5S