DAP-81

Product Name: DAP-81
CAS No.: 794466-17-4
Chemical Name: DAP-81
Synonyms: DAP-81;Acetamide, N-[4-[[4-[(2-benzoylphenyl)amino]-5-nitro-2-pyrimidinyl]amino]phenyl]-
CBNumber: CB22731043
Molecular Formula: C25H20N6O4
Formula Weight: 468.46
MOL File: 794466-17-4.mol

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Hazard and Precautionary Statements (GHS)

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DAP-81 Chemical Properties,Usage,Production

Description

DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules. Other spindle tubules are stabilized, resulting in monopolar mitotic spindles. In vitro, DAP-81 inhibits Plk1 at an IC50 of 0.9 nM. DAP-81 is currently in ongoing preclinical evaluations.

Uses

DAP-81 is an inhibitory agent targeting Polo-like kinases (Plks), a class of evolutionarily conserved serine/threonine kinases. DAP-81 dose-dependently increases the number of monopolar spindles in treated cells. High-resolution live-cell microscopy revealed that Plk activity is required for the assembly and maintenance of bipolar mitotic spindles. Plk inhibition destabilizes centromeric microtubules while stabilizing other spindle microtubules, leading to the formation of monopolar spindles. Further testing of compounds based on "privileged scaffolds" such as the DAP scaffold may lead to the discovery of new cell division probes and anti-microtubule agents.

References

[1] Probing cell-division phenotype space and Polo-like kinase function using small molecules

DAP-81 Preparation Products And Raw materials

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Preparation Products

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DAP-81 Suppliers

China 5 United States 2 Global 7

Hangzhou ChangCun Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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794466-17-4, DAP-81Related Search:

DAP-81

Acetamide, N-[4-[[4-[(2-benzoylphenyl)amino]-5-nitro-2-pyrimidinyl]amino]phenyl]-

794466-17-4