ChemicalBook > CAS DataBase List > DAP-81
DAP-81
- Product Name
- DAP-81
- CAS No.
- 794466-17-4
- Chemical Name
- DAP-81
- Synonyms
- DAP-81;Acetamide, N-[4-[[4-[(2-benzoylphenyl)amino]-5-nitro-2-pyrimidinyl]amino]phenyl]-
- CBNumber
- CB22731043
- Molecular Formula
- C25H20N6O4
- Formula Weight
- 468.46
- MOL File
- 794466-17-4.mol
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DAP-81 Chemical Properties,Usage,Production
Description
DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules. Other spindle tubules are stabilized, resulting in monopolar mitotic spindles. In vitro, DAP-81 inhibits Plk1 at an IC50 of 0.9 nM. DAP-81 is currently in ongoing preclinical evaluations.
DAP-81 Preparation Products And Raw materials
Raw materials
Preparation Products
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