ChemicalBook > CAS DataBase List > 4-(2-methoxy-2-oxoethyl)benzoic acid

4-(2-methoxy-2-oxoethyl)benzoic acid

Product Name: 4-(2-methoxy-2-oxoethyl)benzoic acid
CAS No.: 87524-66-1
Chemical Name: 4-(2-methoxy-2-oxoethyl)benzoic acid
Synonyms: 4-(2-methoxy-2-oxoethyl)benzoic acid;4-Carboxy-benzeneacetic acid methyl ester;Benzeneacetic acid, 4-carboxy-, a-methyl ester;Benzeneacetic acid, 4-carboxy-, 1-Methyl ester
CBNumber: CB22734781
Molecular Formula: C10H10O4
Formula Weight: 194.19
MOL File: 87524-66-1.mol

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4-(2-methoxy-2-oxoethyl)benzoic acid Property

Melting point:: 136 °C
Boiling point:: 331.0±25.0 °C(Predicted)
Density: 1.254±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 4.16±0.10(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: M486118
Product name: 4-(2-methoxy-2-oxoethyl)benzoicAcid
Packaging: 50mg
Price: $220
Updated: 2021/12/16

AK Scientific

Product number: 9552CU
Product name: 4-(2-Methoxy-2-oxoethyl)benzoicacid
Packaging: 1g
Price: $340
Updated: 2021/12/16

Matrix Scientific

Product number: 152266
Product name: 4-((Methoxycarbonyl) methyl)benzoic acid
Purity: 95%
Packaging: 1g
Price: $445
Updated: 2021/12/16

Ambeed

Product number: A241650
Product name: 4-(2-Methoxy-2-oxoethyl)benzoicacid
Purity: 95%
Packaging: 100mg
Price: $49
Updated: 2021/12/16

Ambeed

Product number: A241650
Product name: 4-(2-Methoxy-2-oxoethyl)benzoicacid
Purity: 95%
Packaging: 250mg
Price: $83
Updated: 2021/12/16

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4-(2-methoxy-2-oxoethyl)benzoic acid Chemical Properties,Usage,Production

Synthesis

67-56-1

501-89-3

87524-66-1

General procedure for the synthesis of methyl 4-carboxyphenylacetate from methanol and 4-(carboxymethyl)benzoic acid: to a solution of 4-(carboxymethyl)benzoic acid (1.00 g, 5.55 mmol, 1 eq.) in methanol (11 mL) was added thionyl chloride (0.020 mL, 0.28 mmol, 5 mol%). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure and the residue was dissolved in methyl tertiary butyl ether (MTBE). It was washed three times sequentially with saturated NaHCO3 solution and once more with water. The bicarbonate and aqueous phase extracts were combined and acidified with 1N HCl until the monomethyl ester precipitated. The mixture was extracted three times with MTBE, the organic layers were combined and dried with anhydrous Na2SO4. Concentration of the organic layer under reduced pressure afforded 4-(2-methoxy-2-oxoethyl)benzoic acid (12) (0.985 g, 91% yield) as a white solid.1H NMR (CDCl3, 400 MHz) δ 8.08 (d, 2H, J = 8.4Hz), 7.40 (d, 2H, J = 8.4Hz), 3.72 (s, 5H). The data obtained are in agreement with those reported in the literature WO2005/12220.

References

[1] Patent: WO2016/199111, 2016, A1. Location in patent: Paragraph 00146-00147
[2] Journal of Chemical Research - Part S, 1999, # 6, p. 378 - 379
[3] Patent: WO2005/12220, 2005, A2. Location in patent: Page/Page column 113
[4] Patent: WO2013/41407, 2013, A1. Location in patent: Page/Page column 34
[5] Patent: WO2014/125426, 2014, A1. Location in patent: Page/Page column 40

4-(2-methoxy-2-oxoethyl)benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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87524-66-1, 4-(2-methoxy-2-oxoethyl)benzoic acidRelated Search:

4-(2-methoxy-2-oxoethyl)benzoic acid

Benzeneacetic acid, 4-carboxy-, 1-Methyl ester

4-Carboxy-benzeneacetic acid methyl ester

Benzeneacetic acid, 4-carboxy-, a-methyl ester

87524-66-1