ChemicalBook > CAS DataBase List > ABBV-075

ABBV-075

Product Name: ABBV-075
CAS No.: 1445993-26-9
Chemical Name: ABBV-075
Synonyms: Mivebresib;5100;Mivibus;CS-2464;CS-2213;ABBV-075;Mivebresib (ABBV-075 );Mivebresib, 10 mM in DMSO;ABBV-075; ABBV075; ABBV 075;Terbufos Impurity 12 (Vamidothion)
CBNumber: CB22738567
Molecular Formula: C22H19F2N3O4S
Formula Weight: 459.47
MOL File: 1445993-26-9.mol

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ABBV-075 Property

Boiling point:: 608.9±65.0 °C(Predicted)
Density: 1.465±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:60.0(Max Conc. mg/mL);130.59(Max Conc. mM)
form: A crystalline solid
pka: 8.37±0.10(Predicted)
color: White to off-white
InChI: InChI=1S/C22H19F2N3O4S/c1-3-32(29,30)26-14-5-7-19(31-20-6-4-13(23)10-18(20)24)16(11-14)17-12-27(2)22(28)21-15(17)8-9-25-21/h4-12,25-26H,3H2,1-2H3
InChIKey: RDONXGFGWSSFMY-UHFFFAOYSA-N
SMILES: C(S(NC1=CC=C(OC2=CC=C(F)C=C2F)C(C2=CN(C)C(=O)C3NC=CC=32)=C1)(=O)=O)C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21033
Product name: ABBV-075
Purity: ≥98%
Packaging: 500μg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21033
Product name: ABBV-075
Purity: ≥98%
Packaging: 1mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 21033
Product name: ABBV-075
Purity: ≥98%
Packaging: 5mg
Price: $169
Updated: 2024/03/01

Cayman Chemical

Product number: 21033
Product name: ABBV-075
Purity: ≥98%
Packaging: 10mg
Price: $305
Updated: 2024/03/01

ChemScene

Product number: CS-5815
Product name: Mivebresib
Purity: 99.69%
Packaging: 50mg
Price: $540
Updated: 2021/12/16

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ABBV-075 Chemical Properties,Usage,Production

Uses

ABBV 075-d5 is a deuterium labelled ABBV 075 (A215280), which is used for selective inhibition of the BD2 bromodomain of bromodomain and extra-??terminal proteins in prostate cancer.

Biological Activity

Mivebresib (ABBV-075) is a novel BET family bromodomain inhibitor. Binds to the bromodomain of BRD2/4/T with similar affinity (Ki values between 1-2.2 nM) with high selectivity. Low potency against BRD3 (Ki=12.2 nM) and moderate activity against CREBBP (Ki=87 μM). It can effectively trigger apoptosis in a variety of tumor cells.

in vitro

ABBV-075 has potent and potent single-agent activity in a variety of cancer cell lines (from solid tumors, leukemias and lymphomas) in cell viability assays. It is capable of disrupting cell cycle control, leading to G1 arrest, further senescence, inhibition of tumor formation, induction of apoptosis, and possibly targeting the tumor microenvironment to further provide better efficacy.

in vivo

In mouse models laterally xenografted with non-small cell and small cell lung cancer, pancreatic cancer, breast cancer, prostate cancer, head and neck cancer, multiple lymphomas, diffuse giant B-cell lymphoma, and leukemia, ABBV -075 has equal or better efficacy than other standard care agents.

target

Target	Value
BRD2
BRD4
BRD-T

ABBV-075 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ABBV-075 manufacturers

Career Henan Chemical Co

Product: ABBV-075 1445993-26-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-25

1445993-26-9, ABBV-075Related Search:

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N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide

ABBV-075

Mivebresib

5100

Mivebresib (ABBV-075 )

ABBV-075; ABBV075; ABBV 075

CS-2213

Mivebresib (ABBV075, ABBV-075, ABBV 075)

CS-2464

Mivibus

Ethanesulfonamide, N-[4-(2,4-difluorophenoxy)-3-(6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]-

Terbufos Impurity 12 (Vamidothion)

Mivebresib, 10 mM in DMSO

1445993-26-9

2115742-03-0