PU-WS13

ChemicalBook > CAS DataBase List > PU-WS13

Product Name: PU-WS13
CAS No.: 1454619-14-7
Chemical Name: PU-WS13
Synonyms: PU-WS13;CS-2047;CS-1689;PU WS13;PUWS13;8-((3,5-dichlorophenyl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine;8-(3,5-dichlorophenyl)sulfanyl-9-[3-(propan-2-ylamino)propyl]purin-6-amine;6-Amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine;9H-Purine-9-propanamine, 6-amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-;8-[(3,5-dichlorophenyl)sulfanyl]-9-{3-[(propan-2-yl)amino]propyl}-9H-purin-6-amine
CBNumber: CB22742078
Molecular Formula: C17H20Cl2N6S
Formula Weight: 411.35
MOL File: 1454619-14-7.mol

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PU-WS13 Property

Boiling point:: 617.4±65.0 °C(Predicted)
Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMF: 30 mg/mL,DMSO: 30 mg/mL,DMSO:PBS(pH7.2) (1:1): 0.5 mg/mL,Ethanol: 25 mg/mL
form: Powder
pka: 10.15±0.29(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18409
Product name: PU-WS13
Purity: ≥98%
Packaging: 1mg
Price: $36
Updated: 2022/04/27

Cayman Chemical

Product number: 18409
Product name: PU-WS13
Purity: ≥98%
Packaging: 5mg
Price: $91
Updated: 2022/04/27

Cayman Chemical

Product number: 18409
Product name: PU-WS13
Purity: ≥98%
Packaging: 10mg
Price: $143
Updated: 2022/04/27

Cayman Chemical

Product number: 18409
Product name: PU-WS13
Purity: ≥98%
Packaging: 25mg
Price: $269
Updated: 2022/04/27

TRC

Product number: P840335
Product name: PU-WS13
Packaging: 100mg
Price: $790
Updated: 2021/12/16

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PU-WS13 Chemical Properties,Usage,Production

Description

PU-WS13 is an inhibitor of the heat shock protein family member and chaperone protein glucose-regulated protein 94 (GRP94; IC₅₀ = 0.22 μM). It is selective for GRP94 over the chaperones Hsp90α, Hsp90β, and TRAP1 (IC₅₀s = 27.3, 41.8, and 7.3 μM, respectively). PU-WS13 (0.5, 2.5, and 12.5 μM) induces apoptosis without increasing Hsp70 protein levels in HER2-overexpressing SK-BR-3, BT474, and MDA-MB-361 breast cancer cells. It also induces apoptosis and necrosis in multiple myeloma cells but does not induces cell death in pre-B leukemic cells.

Uses

PU-WS13 is a pharmaceutical agent used in the preparation go paralog=selective HSP90 inhibitors used in anti-tumor treatments.

PU-WS13 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from PU-WS13 manufacturers

Career Henan Chemical Co

Product: PU-WS13 1454619-14-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98-100%
Supply Ability: 1000kg
Release date: 2018-08-20

1454619-14-7, PU-WS13Related Search:

PU-WS13

8-((3,5-dichlorophenyl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine

6-Amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine

8-(3,5-dichlorophenyl)sulfanyl-9-[3-(propan-2-ylamino)propyl]purin-6-amine

PU WS13;PUWS13

CS-1689

CS-2047

9H-Purine-9-propanamine, 6-amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-

8-[(3,5-dichlorophenyl)sulfanyl]-9-{3-[(propan-2-yl)amino]propyl}-9H-purin-6-amine

1454619-14-7

C17H20Cl2N6S