ChemicalBook > CAS DataBase List > (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide
(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide
Uses- Product Name
- (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide
- CAS No.
- 1192651-49-2
- Chemical Name
- (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide
- Synonyms
- Avibactam Impurity 57;Avibactam Impurity 56（2S,5R);Avibactam Impurity（2S,5R-A9）;AVIBACTAM SODIUM INTERMEDIATE;Avibactam sodium intermediate3;(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-...;(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;(1R,2S,5R)-6-(Benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;(1R,2S,5R)-7-Oxo-6-(phenylmethoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;1,6-Diazabicyclo[3.2.1]octane-2-carboxamide, 7-oxo-6-(phenylmethoxy)-, (1R,2S,5R)-
- CBNumber
- CB22744618
- Molecular Formula
- C14H17N3O3
- Formula Weight
- 275.3
- MOL File
- 1192651-49-2.mol
More
Less
(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide Property
- Boiling point:
- 543.6±30.0 °C(Predicted)
- Density
- 1.36±0.1 g/cm3(Predicted)
- pka
- 17.19±0.20(Predicted)
More
Less
N-Bromosuccinimide Price
TRC
- Product number
- B287515
- Product name
- (2S,5R)-6-(Benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide
- Packaging
- 5mg
- Price
- $65
- Updated
- 2021/12/16
TRC
- Product number
- B287515
- Product name
- (2S,5R)-6-(Benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide
- Packaging
- 10mg
- Price
- $125
- Updated
- 2021/12/16
Alichem
- Product number
- 1192651492
- Product name
- (1R,2S,5R)-6-(Benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide
- Packaging
- 250mg
- Price
- $704.16
- Updated
- 2021/12/16
Alichem
- Product number
- 1192651492
- Product name
- (1R,2S,5R)-6-(Benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide
- Packaging
- 1g
- Price
- $1581.1
- Updated
- 2021/12/16
More
Less
(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide Chemical Properties,Usage,Production
Uses
(2S,5R)-6-(Benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide is an impurity of Avibactam; a novel β-lactamase inhibitor with a non-lactam structural scaffold. Avibactam irreversibly inhibits lactamase from Mycobacterium tuberculosis.
Uses
(2S,5R)-6-(Benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide is an impurity of Avibactam (A794850, Na Salt); a novel β-lactamase inhibitor with a non-lactam structural scaffold. Avibactam irreversibly inhibits lactamase from Mycobacterium tuberculosis.
Synthesis
(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide is synthesised using (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid as a raw material by chemical reaction. The specific synthesis steps are as follows:
DIPEA (5.8 mL, 36.2 mmol) was added to a solution of (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diaza-bicyclo[3.2.1]octane-2-carboxylic acid (5.0 g, 18.1 mmol), EDCI (5.2 g, 27.2 mmol), HOBT (3.7 g, 27.2 mmol) and NH4Cl (1.94 g, 36.2 mmol) in DMF (60 mL) at rt. The reaction mixture was stiffed for 17 hrs, then diluted with ice water (100 mL) and extracted with EtOAc (3*). The combined organic layer was dried over Na2SO4, and concentrated. The residue was purified by silica gel column chromatography (2:1 EtOAc/petroleum ether) to afford (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diaza-bicyclo[3.2.1]octane-2-carboxamide (4.0 g, 80%) as a white solid. ESI-MS (EI+, m/z): 276 [M+H]+.
(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide Suppliers
- Tel
- 0756-0756-6811852 15876689832
- Fax
- 0756-6811857
- zhyrpharm_sales03@126.com
- Country
- China
- ProdList
- 287
- Advantage
- 55
- Tel
- 760-85282375 13212762451
- marketing@enantiotech.net
- Country
- China
- ProdList
- 153
- Advantage
- 55
- Tel
- +8615621883869 15621883869
- liutf@jewim.com.cn
- Country
- China
- ProdList
- 110
- Advantage
- 58
- Tel
- +86-15552645780 +86-17658510842
- 17658510842@163.com
- Country
- China
- ProdList
- 20
- Advantage
- 58
- Tel
- 28-83379370 13880556291
- Fax
- 028-87747383
- tcy@tcypharm.com
- Country
- China
- ProdList
- 510
- Advantage
- 57
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14103
- Advantage
- 59
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 022-66211079 13212288319
- Fax
- qq1405432731
- sales@chempharmatech.com
- Country
- China
- ProdList
- 879
- Advantage
- 55
- Tel
- 0574-87365517 18074210286
- Fax
- 87367735
- sales@taikangchem.com
- Country
- China
- ProdList
- 303
- Advantage
- 58
- Tel
- 0512-62857507
- Fax
- +86-512-62857507
- sales@sinorarechem.com
- Country
- China
- ProdList
- 995
- Advantage
- 58
- Tel
- 18101936766
- Fax
- 021-58583907
- eileen@shmychem.com
- Country
- China
- ProdList
- 350
- Advantage
- 55
- Tel
- 022-25349927 15900252761
- Fax
- 022-25349927
- saichen_sales@hotmail.com
- Country
- China
- ProdList
- 101
- Advantage
- 55
- Tel
- 025-66023220 0086-15250997978
- Fax
- 025-58362220
- 1511893459@qq.com
- Country
- China
- ProdList
- 7892
- Advantage
- 55
- Tel
- +86-023- 68549356 023-68548079
- Fax
- +86-023-68442044
- clive.yang@consciencepharma.com
- Country
- China
- ProdList
- 28
- Advantage
- 60
- Tel
- 13764913901
- Fax
- -
- info@angtibio.com
- Country
- China
- ProdList
- 5028
- Advantage
- 55
- Tel
- 021-51619050 13301662590
- Fax
- +86-21-51619052
- mandy@atkchemical.com
- Country
- China
- ProdList
- 7776
- Advantage
- 55
- Tel
- 021-20786057 18918495077
- Fax
- 021-20786057
- 3116390381@qq.com
- Country
- China
- ProdList
- 220
- Advantage
- 58
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9923
- Advantage
- 55
- Tel
- 0317-5296180 15533709196
- Fax
- 0317-5106596
- sale@enkepharma.com
- Country
- China
- ProdList
- 2007
- Advantage
- 55
- Tel
- 17754423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8011
- Advantage
- 62
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 025-66113011 18112977050
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 16027
- Advantage
- 58
- Tel
- 021-61469567 13482353728
- Fax
- 021-61161605
- sales@fdc-chemical.com
- Country
- China
- ProdList
- 15006
- Advantage
- 58
- Tel
- 027-87466105 15377573527
- 2678564200@qq.com
- Country
- China
- ProdList
- 17987
- Advantage
- 58
- Tel
- 0371-67991738 13783628208
- Fax
- QQ 412703949
- carl@alchemist-pharm.com
- Country
- China
- ProdList
- 1872
- Advantage
- 58
- Tel
- 15966937598
- Fax
- 3407640895 3071519937
- 3407650895@qq.com
- Country
- China
- ProdList
- 1256
- Advantage
- 58
- Tel
- 025-84767922 18936879710
- sales@abydoscientific.com
- Country
- China
- ProdList
- 1010
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52693
- Advantage
- 58
- Tel
- 18019463053
- Fax
- 021-50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 13010
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57423
- Advantage
- 58
- Tel
- 010-86203349 18201082367
- bosennuokang@163.com
- Country
- China
- ProdList
- 220
- Advantage
- 58
- Tel
- 025-66110311 13155353615
- qzhang@aikonchem.com
- Country
- China
- ProdList
- 15527
- Advantage
- 58
- Tel
- 020-61855200 13326451905
- 260366801@qq.com
- Country
- China
- ProdList
- 7824
- Advantage
- 58
- Tel
- Country
- China
- ProdList
- 12003
- Advantage
- 58
- Tel
- +8615255079626
- eric@witopchemical.com
- Country
- China
- ProdList
- 23541
- Advantage
- 58
- Tel
- +86-0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25356
- Advantage
- 58
- Tel
- +8615986615575
- Fax
- 0086-13651442114
- info@codchem.com
- Country
- China
- ProdList
- 20342
- Advantage
- 58
- Tel
- +86-0571-85134551
- Fax
- 008657185134895
- sales@afinechem.com
- Country
- China
- ProdList
- 15352
- Advantage
- 58
- Tel
- 86-21-51086038
- Fax
- 86-21-51861608
- chemwill_asia@126.com
- Country
- CHINA
- ProdList
- 23912
- Advantage
- 58
- Tel
- 18601331139
- Fax
- QQ:3454155726
- BD@chempion.com.cn
- Country
- China
- ProdList
- 138
- Advantage
- 58
- Tel
- 021-51870955
- Fax
- 021-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 817
- Advantage
- 58
- Tel
- +86 028-84641798 15982321820
- abby@arkpharm.com
- Country
- China
- ProdList
- 10923
- Advantage
- 58
- Tel
- +86-023-6139-8061 +86-86-13650506873
- sales@chemdad.com
- Country
- China
- ProdList
- 39894
- Advantage
- 58
- Tel
- 0755-61348847 17820674378
- Fax
- 0755-21016893
- 2682116078@qq.com
- Country
- China
- ProdList
- 7843
- Advantage
- 58
- Tel
- +8618523575427
- sales@conier.com
- Country
- China
- ProdList
- 49476
- Advantage
- 58
- Tel
- +86-29-81148696 +86-15536356810
- 1022@dideu.com
- Country
- China
- ProdList
- 3882
- Advantage
- 58
- Tel
- 400-820-6829
- sales@mitachieve.com
- Country
- China
- ProdList
- 8860
- Advantage
- 58
- Tel
- 0531-88723173 18596073690
- 1047208234@qq.com
- Country
- China
- ProdList
- 4973
- Advantage
- 58
- Tel
- 16621358918
- Fax
- QQ:402135374
- botuopharma888@163.com
- Country
- China
- ProdList
- 9208
- Advantage
- 58
- Tel
- 027-52344656 15871722230
- Fax
- 2796190295
- 15871722230@163.com
- Country
- China
- ProdList
- 4999
- Advantage
- 58
More
Less
View Lastest Price from (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 1192651-49-2
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2020-04-24
Henan Fengda Chemical Co., Ltd
- Product
- (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 1192651-49-2
- Price
- US $31.00-1.20/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-22
Henan Aochuang Chemical Co.,Ltd.
- Product
- (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 1192651-49-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-29
1192651-49-2, (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamideRelated Search:
Avibactam INT 1
Avibactam Impurity 15
(2S,5R)-5-[(benzyloxy)amino]piperidine-2-carboxamide
Avibactam Impurity 28
Avibactam Impurity 1
Avibactam Impurity
L-Norleucine, 6-chloro-N-[(1,1-dimethylethoxy)carbonyl]-5-[(phenylmethoxy)imino]-, phenylmethyl ester
O-(Benzyloxymethyl)hydroxylamine
POLYMYXIN B NONAPEPTIDE HYDROCHLORIDE
Benzyl (2S,5R)-5-[(benzyloxy)amino]piperidine-2-carboxylate ethanedioate
Avibactam Impurity 10
Avibactam Sodium Isomer
Trans-5-(Benzyloxyamino)piperidine-2-carboxylic acid
5-HYDROXYPYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
Avibactam Impurity
ethyl (S)-5-oxopiperidine-2-carboxylate
Avibactam Impurity 13
Avibactam Impurity 4