Isopropyl 2-(acetylamino)-2-deoxy á-D-glucopyranoside 3,4,6-triacetate

Product Name: Isopropyl 2-(acetylamino)-2-deoxy á-D-glucopyranoside 3,4,6-triacetate
CAS No.: 40592-88-9
Chemical Name: Isopropyl 2-(acetylamino)-2-deoxy á-D-glucopyranoside 3,4,6-triacetate
Synonyms: C34;TLR4-C34;TLR4-IN-C34;2-Acetamidopyranoside;Isopropyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranoside;Isopropyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranoside;ISOPROPYL 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSIDE 3,4,6-TRIACETATE;Isopropyl 2-(acetylamino)-2-deoxy á-D-glucopyranoside 3,4,6-triacetate;1-Methylethyl 2-(acetylamino)-2-deoxy-a-Dglucopyranoside 3,4,6-triacetate;1-Methylethyl 2-(acetylamino)-2-deoxy-α-D-glucopyranoside 3,4,6-triacetate
CBNumber: CB22750507
Molecular Formula: C17H27NO9
Formula Weight: 389.39758
MOL File: 40592-88-9.mol

More

Less

Isopropyl 2-(acetylamino)-2-deoxy á-D-glucopyranoside 3,4,6-triacetate Property

Boiling point:: 519.8±50.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: H2O: soluble1mg/mL, clear (warmed)
pka: 13?+-.0.70(Predicted)
form: powder
color: white to beige

More

Less

Safety

WGK Germany: 3
HS Code: 2938900000

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0832
Product name: TLR4-IN-C34
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0832
Product name: TLR4-IN-C34
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $478
Updated: 2024/03/01

Cayman Chemical

Product number: 18512
Product name: TLR4-C34
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 18512
Product name: TLR4-C34
Purity: ≥98%
Packaging: 10mg
Price: $110
Updated: 2024/03/01

Cayman Chemical

Product number: 18512
Product name: TLR4-C34
Purity: ≥98%
Packaging: 25mg
Price: $253
Updated: 2024/03/01

More

Less

Isopropyl 2-(acetylamino)-2-deoxy á-D-glucopyranoside 3,4,6-triacetate Chemical Properties,Usage,Production

Uses

TLR4-IN-C34 is a new class of toll-like receptor 4 (TLR4) inhibitors, which are potential anti-inflammatory agents.

General Description

TLR4-IN-C34 is an inhibitor of toll-like receptor 4 (TLR4) in vitro and in vivo.

Biological Activity

c34 is a 2-acetamidopyranoside that inhibits tlr4 signaling in enterocytes and macrophages in vitro when used at 10 μm. it does not affect signaling through either tlr2 or tlr9[1,2].c34, used at 1 mg/kg can reduce systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis[1].c34 markedly decreases the basal expression of tnfα, as well as lps-induced inos and tnfα expression, in intestinal tissue isolated from patients with necrotizing enterocolitis[1].[1]. neal m d, jia h, eyer b, et al. discovery and validation of a new class of small molecule toll-like receptor 4 (tlr4) inhibitors. plos one, 2013, 8(6): e65779.[2]. wipf p, eyer b r, yamaguchi y, et al. synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (tlr4). tetrahedron letters, 2015, 56(23): 3097-3100.

Biochem/physiol Actions

TLR4-IN-C34 is a potent and specific inhibitor of toll-like receptor 4 (TLR4), which inhibits TLR4 signaling in vivo and in vitro. TLR4-IN-C34, also known as C34, is an aminomonosaccharide that inhibits TLR4 signaling by docking with the hydrophobic pocket of the TLR4 co-receptor, myeloid differentiation protein-2 (MD-2). C34 has been shown to diminish the severity of experimental necrotizing enterocolitis (NEC).

storage

Store at -20°C

Isopropyl 2-(acetylamino)-2-deoxy á-D-glucopyranoside 3,4,6-triacetate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Isopropyl 2-(acetylamino)-2-deoxy á-D-glucopyranoside 3,4,6-triacetate Suppliers

China 63 India 1 United Kingdom 3 United States 11 Global 78

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

40592-88-9, Isopropyl 2-(acetylamino)-2-deoxy á-D-glucopyranoside 3,4,6-triacetateRelated Search:

Isopropyl 2-acetamido-3,4,6-tri-O-ethyl-2-deoxy-α-D-glucopyranoside 1-Methylethyl 2-(acetylamino)-2-deoxy-alpha-D-glucopyranoside

2-Acetamidopyranoside

C34

Isopropyl 2-(acetylamino)-2-deoxy á-D-glucopyranoside 3,4,6-triacetate

TLR4-IN-C34

TLR4-C34

Isopropyl 2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-alpha-D-glucopyranoside, Min. 98%

1-Methylethyl 2-(acetylamino)-2-deoxy-α-D-glucopyranoside 3,4,6-triacetate

1-Methylethyl 2-(acetylamino)-2-deoxy-a-Dglucopyranoside 3,4,6-triacetate

Isopropyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranoside

ISOPROPYL 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSIDE 3,4,6-TRIACETATE

(2R,3S,4R,5R,6S)-5-Acetamido-2-(acetoxymethyl)-6-isopropoxytetrahydro-2H-pyran-3,4-diyl diacetate

Isopropyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranoside

TLR4 IN C34,Toll-like Receptor (TLR),Inhibitor,TLR4INC34,inhibit,TLR-4-IN-C34

α-D-Glucopyranoside, 1-methylethyl 2-(acetylamino)-2-deoxy-, 3,4,6-triacetate

40592-88-9

API