4-Chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-benzamide
- Product Name
- 4-Chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-benzamide
- CAS No.
- 865285-29-6
- Chemical Name
- 4-Chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-benzamide
- Synonyms
- SRJ-23;KKL-35;KKL-35 (KKL 35;KKL-35 >=98% (HPLC);KKL35,Bacterial,Inhibitor,KKL 35,inhibit,KKL-35;4-Chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-benzamide;Benzamide, 4-chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-
- CBNumber
- CB22750608
- Molecular Formula
- C15H9ClFN3O2
- Formula Weight
- 317.7
- MOL File
- 865285-29-6.mol
4-Chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-benzamide Property
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: soluble5mg/mL, clear (warmed)
- form
- powder
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-6884
- Product name
- KKL-35
- Purity
- 99.42%
- Packaging
- 1mg
- Price
- $360
- Updated
- 2021/12/16
- Product number
- CS-6884
- Product name
- KKL-35
- Purity
- 99.42%
- Packaging
- 5mg
- Price
- $792
- Updated
- 2021/12/16
- Product number
- CS-6884
- Product name
- KKL-35
- Purity
- 99.42%
- Packaging
- 10mg
- Price
- $1188
- Updated
- 2021/12/16
- Product number
- DC22833
- Product name
- KKL-35
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1100
- Updated
- 2021/12/16
4-Chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-benzamide Chemical Properties,Usage,Production
Biological Activity
KKL-35 inhibits trans-translation tagging reaction with IC50 of 0.9 μM. It has broad-spectrum antibiotic activity.
in vitro
KKL-35 exhibits broad-spectrum antibiotic activity. It prevents growth of B. anthracis and M. smegmatis with minimum inhibitory concentration (MIC) values of less than 6 μM. It inhibits trans-translation at some step before proteolysis of tagged proteins. It inhibits tagging of DHFR-ns. A large amount of untagged DHFR is produced in reactions with the highest concentrations of it, indicating that it does not inhibit translation. It prevents growth of WT S. flexneri with a MIC of 6 μM, and addition of it to a growing culture of S. flexneri stops growth. In an S. flexneri strain expressing ArfA and deleted for ssrA, addition of it has little effect on viability or growth rate. It inhibits the growth of E. coli ?tolC, which is deficient in small molecule efflux, with an MIC of 0.3 μM.
in vivo
Evidence suggest that the in vivo effects of KKL-35 are caused by inhibition of the release of nonstop translation complexes by trans-translation. It inhibits trans-translation and prevents growth of S. flexneri strains that require trans-translation. The correlation between inhibition of trans-translation and growth is supported by genetic and pharmacological experiments showing that alternative mechanisms to release nonstop translation complexes relieve the growth suppression of KKL-35.
target
IC50: 0.9 μM ( trans -translation tagging reaction)
4-Chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-benzamide Preparation Products And Raw materials
Raw materials
Preparation Products
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