AC-262536
- Product Name
- AC-262536
- CAS No.
- 870888-46-3
- Chemical Name
- AC-262536
- Synonyms
- AC262;AC-262,356;ACP-262;Accadine;AC-262536;AC-262536;AC262;AC-262536 powder;4-(3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl)naphthalene-1-;1-Naphthalenecarbonitrile,4-[(3-endo)-3-hydroxy-8-azabicyclo...;4-(3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl)naphthalene-1-carbonitrile
- CBNumber
- CB22750956
- Molecular Formula
- C18H18N2O
- Formula Weight
- 278.36
- MOL File
- 870888-46-3.mol
AC-262536 Property
- Melting point:
- 158-162°C
- Boiling point:
- 526.0±45.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: Soluble
- pka
- 14.73±0.20(Predicted)
- InChI
- InChI=1/C18H18N2O/c19-11-12-5-8-18(17-4-2-1-3-16(12)17)20-13-6-7-14(20)10-15(21)9-13/h1-5,8,13-15,21H,6-7,9-10H2/t13-,14+,15+
- InChIKey
- ATKWLNSCJYLXPF-FICVDOATNA-N
- SMILES
- O[C@H]1C[C@H]2CC[C@H](N2C2=CC=C(C#N)C3C=CC=CC2=3)C1 |&1:1,3,6,r|
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- SML3278
- Product name
- AC-262536
- Purity
- ≥95% (HPLC)
- Packaging
- 10MG
- Price
- $87
- Updated
- 2024/03/01
- Product number
- SML3278
- Product name
- AC-262536
- Purity
- ≥95% (HPLC)
- Packaging
- 50MG
- Price
- $350
- Updated
- 2024/03/01
- Product number
- DC53055
- Product name
- AC-262536
- Packaging
- 1g
- Price
- $1800
- Updated
- 2021/12/16
AC-262536 Chemical Properties,Usage,Production
Uses
AC-262536 is a hydrocarbon organic matter and can be used as pharmaceutical intermediates.
General Description
AC-262536 is a selective nonsteroidal androgen receptor modulator (SARM) with beneficial anabolic effects. AC-262536 has potent agonist activity against androgen receptors with affinity in the low nanomolar range (1-10 nM). It is another novel drug put forth by Acadia, just like ACP-105. It is a SARM by design, as it selectively binds to the androgen receptor, just like all the other SARMs. AC-262536 came into light in 2007 and even though 13 years have passed, little research has been done on this compound.
Biological Activity
AC-262536 exhibits potency at AR similar to that observed for the natural ligand testosterone, 13 nM vs. 2 nM, respectively. Interestingly, AC-262536 behaved as a partial agonist (% Eff 67 ± 9) relative to testosterone. In reporter gene assays, AC-262536 modulated the transcriptional activity of a natural target gene in an AR-dependent manner with low nanomolar potency (2 nM). It displayed partial agonism properties (% Eff 72 ± 9) relative to testosterone. Further, AC-262536 physically interacted with AR with an affinity of 5 nM. Profiling at other nuclear receptors revealed that AC-262536 is extremely selective for AR, having no significant affinity for the other 47 human nuclear receptors, including the steroid receptors estrogen ERs, glucocorticoid GR, mineraloid MR, and progesterone PR, at doses as high as 10M (data not shown)[1].
Side effects
Testosterone Suppression: AC-262536 will suppress your natural testosterone levels. Compared to other SARMs, this suppression of testosterone is rather mild and similar to that of Ostarine and Andarine. Testosterone suppression can manifest in the following symptoms: Lethargy, Lack of motivation, Decreased libido, Weaker erections, Testicular pain, and Testicular atrophy. AC-262536 will cause dyslipidemia. Your HDL will decrease, and your LDL will increase during an AC-262 cycle. The extent of this side effect can be compared to that of similarly strong SARMs. The following side effects can happen to anyone who alters their endocrine balance, regardless of whether they’re taking AC-262 or something else: Gynecomastia: men who had pubertal gyno are at risk of redeveloping it if they take AC-262536; Hair shedding (temporary and completely reversible); Insomnia.
References
[1] Fabrice Piu . “Pharmacological characterization of AC-262536, a novel selective androgen receptor modulator.” Journal of Steroid Biochemistry and Molecular Biology 109 1 (2008): Pages 129-137.
AC-262536 Preparation Products And Raw materials
Raw materials
Preparation Products
AC-262536 Suppliers
- Tel
- 13345898948
- 1301260554@qq.com
- Country
- China
- ProdList
- 105
- Advantage
- 58
- Tel
- 400-8592883 15367835770
- Fax
- 0731-82251112
- viola@huatengsci.com
- Country
- China
- ProdList
- 5877
- Advantage
- 58
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51471
- Advantage
- 80
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9708
- Advantage
- 58
- Tel
- 027-83778876 13667159345
- Fax
- 027-83778876
- 13667159345@163.com
- Country
- China
- ProdList
- 1966
- Advantage
- 55
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 15085
- Advantage
- 58
- Tel
- 0371-0371-55051623 18137891487
- Fax
- QQ：2853979817
- 2853979817@qq.com
- Country
- China
- ProdList
- 9890
- Advantage
- 58
- Tel
- 0371-0371-63315541 13323832564
- Fax
- QQ:3001332135
- 3001332135@qq.com
- Country
- China
- ProdList
- 9990
- Advantage
- 58
- Tel
- +86-18665676617
- Fax
- 18665676617
- Country
- China
- ProdList
- 958
- Advantage
- 58
- Tel
- +8615255079626
- eric@witopchemical.com
- Country
- China
- ProdList
- 23556
- Advantage
- 58
- Tel
- +8618339805032
- alfa4@alfachem.cn
- Country
- China
- ProdList
- 13039
- Advantage
- 58
- Tel
- +862156762820 +86-13564624040
- sales@myuchem.com
- Country
- China
- ProdList
- 6839
- Advantage
- 58
- Tel
- +86-18031140164 +86-19933155420
- erin@hbldbiotech.com
- Country
- China
- ProdList
- 465
- Advantage
- 58
- Tel
- 0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25363
- Advantage
- 58
- Tel
- +8618942921723
- info@dmksw.xin
- Country
- China
- ProdList
- 723
- Advantage
- 58
- Tel
- +8613367258412
- Fax
- 18062427325
- ada@ipurechemical.com
- Country
- China
- ProdList
- 10326
- Advantage
- 58
- Tel
- +1-2135480471 +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10523
- Advantage
- 58
- Tel
- +86-13296627870; +8613296627870
- Fax
- 0086-27-87819568
- info@whwingroup.com
- Country
- China
- ProdList
- 703
- Advantage
- 58
- Tel
- 0086 18039857276 18039857276
- Country
- CHINA
- ProdList
- 2783
- Advantage
- 58
- Tel
- +8613315996897
- Fax
- 0086-13315996897
- bsterltd.wendy@gmail.com
- Country
- China
- ProdList
- 796
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9412
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11289
- Advantage
- 58
- Tel
- +86-021-61551413 +8618813727289
- contact@trustwe.com
- Country
- China
- ProdList
- 5738
- Advantage
- 58
- Tel
- 0573-0573-82672231 13757365595
- Fax
- QQ：715584339
- regen_chemical1@163.com
- Country
- China
- ProdList
- 4573
- Advantage
- 58
- Tel
- 18672943286
- brian_zhao@whqfchem.com
- Country
- China
- ProdList
- 387
- Advantage
- 58
- Tel
- 027-027-52344656 15871722230
- Fax
- 2796190295
- 15871722230@163.com
- Country
- China
- ProdList
- 2997
- Advantage
- 58
- Tel
- 0717-6855399 15377615856
- sales@sndswyy.cn
- Country
- China
- ProdList
- 83
- Advantage
- 58
- Tel
- 15342225168
- yutianchun2007@126.com
- Country
- China
- ProdList
- 10005
- Advantage
- 58
- Tel
- 0519-85524369
- 3477467573@qq.com
- Country
- China
- ProdList
- 8618
- Advantage
- 58
- Tel
- 021-51816796-820 13611835272
- Fax
- 021-5161 3951
- sales2@sunwaypharm.com
- Country
- China
- ProdList
- 44486
- Advantage
- 58
- Tel
- 15327269642
- Fax
- 15327269642
- 3161971384@qq.com
- Country
- China
- ProdList
- 666
- Advantage
- 58
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6749
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24017
- Advantage
- 58
- Tel
- 027-59105166 13125137732
- 2853863890@qq.com
- Country
- China
- ProdList
- 2953
- Advantage
- 58
- Tel
- 176-03256889 17603256889
- 1123722730@qq.com
- Country
- China
- ProdList
- 3390
- Advantage
- 58
- Tel
- 86-180-3439-5858-5858 18034395858
- Country
- China
- ProdList
- 1085
- Advantage
- 58
- Tel
- 16621771607
- exbio_tech@163.com
- Country
- China
- ProdList
- 8334
- Advantage
- 58
- Tel
- 19713077352 19713077352
- sales@jhbiopharm
- Country
- China
- ProdList
- 1808
- Advantage
- 58
- Tel
- 029-63373950 15353716720
- 1052@dideu.com
- Country
- China
- ProdList
- 10010
- Advantage
- 58
- Tel
- 17362549610
- 312523773@qq.com
- Country
- China
- ProdList
- 115
- Advantage
- 58
- Tel
- 13053322091 13053322091
- admin@mopaikeji.com
- Country
- China
- ProdList
- 10974
- Advantage
- 58
- Tel
- 18120340186
- 3239311947@qq.com
- Country
- China
- ProdList
- 377
- Advantage
- 58
- Tel
- 021-59167510 18117107507
- vip@med-life.cn
- Country
- China
- ProdList
- 5019
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
- 12007
- Advantage
- 58
- Tel
- 17316404525
- 209533805@qq.com
- Country
- China
- ProdList
- 9661
- Advantage
- 58
- Tel
- 852-67545345 13545075487
- sterodschina@gmail.com
- Country
- China
- ProdList
- 311
- Advantage
- 58
- Tel
- 008657128800458; +8615858145714
- Fax
- +86-571-56059825
- fandachem@gmail.com
- Country
- China
- ProdList
- 9338
- Advantage
- 55
- Tel
- +85267545345
- sterodschina@gmail.com
- Country
- China
- ProdList
- 152
- Advantage
- 58
- Tel
- +86-19164747840 +86-13119157289
- 13119157289@163.com
- Country
- China
- ProdList
- 2971
- Advantage
- 58
- Tel
- +8613545065237
- admin@whrchem.com
- Country
- China
- ProdList
- 161
- Advantage
- 58
View Lastest Price from AC-262536 manufacturers
- Product
- AC-262536 870888-46-3
- Price
- US $9.90/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2023-03-30
- Product
- AC-262536 870888-46-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2024-03-26
- Product
- AC-262536 870888-46-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10T
- Release date
- 2024-01-23