2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone

ChemicalBook > CAS DataBase List > 2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone

2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone

Product Name: 2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone
CAS No.: 1429192-00-6
Chemical Name: 2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone
Synonyms: Retro-2;RN 1-001;Retro-2 cycl;Retro-2 >=98% (HPLC);2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolin;2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone;4(1H)-Quinazolinone, 2,3-dihydro-2-(5-methyl-2-thienyl)-3-phenyl-;2-(5-methylthiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one;Arenavirus,Human papillomavirus,Inhibitor,Retro-2 cycl,Virus Protease,Retro 2 cycl,Retro2 cycl,inhibit,HPV
CBNumber: CB22751094
Molecular Formula: C19H16N2OS
Formula Weight: 320.41
MOL File: 1429192-00-6.mol

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2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone Property

storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear (warmed)
form: powder
color: white to beige

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Safety

WGK Germany: 3
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1085
Product name: Retro-2
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1085
Product name: Retro-2
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $498
Updated: 2024/03/01

Cayman Chemical

Product number: 21946
Product name: Retro-2
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21946
Product name: Retro-2
Purity: ≥98%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 21946
Product name: Retro-2
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

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2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone Chemical Properties,Usage,Production

Description

Retro-2 is a selective inhibitor of retrograde protein trafficking mediated by syntaxin-5 at the interface between the endosome and trans-Golgi network, with no discernable effects on other intracellular trafficking pathways. Retro-2 inhibits ebolavirus infection with an EC₅₀ value of 12.2 μM and reduces ricin-induced toxicity by 2.7-fold when used at a concentration of 20 μM in HeLa cells. Retro-2 also blocks JC polyomavirus, BK polyomavirus, and SV40 infectivity in Vero green monkey kidney epithelial cells in vitro (EC₅₀s = 28.4, 61.2, and 58.6 μM, respectively). In mouse models, Retro-2 improves survival and reduces symptoms following infection with Shiga toxin-producing E. coli when administered at a dose of 100 mg/kg and protects against ricin challenge when administered prophylactically at a dose of 2 mg/kg.

Uses

Retro-2 is an inhibitor of Ribosome-Inactivating Proteins (RIPs) as well as a blocker of Leishmania parasitophorous vacuoles (LPV) development.

Biochem/physiol Actions

Retro-2 is a non-toxic inhibitor of the endosome-to-Golgi retrograde transport that selectively protect cells from ricin, cholera toxin, and Shiga-like toxins, without affecting compartment morphology, endogenous retrograde cargos, or other trafficking steps.

2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone Preparation Products And Raw materials

Raw materials

Preparation Products

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1429192-00-6, 2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinoneRelated Search:

2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone

Retro-2

Retro-2 cycl

RN 1-001

4(1H)-Quinazolinone, 2,3-dihydro-2-(5-methyl-2-thienyl)-3-phenyl-

2-(5-methylthiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one

Retro-2 >=98% (HPLC)

2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolin

Arenavirus,Human papillomavirus,Inhibitor,Retro-2 cycl,Virus Protease,Retro 2 cycl,Retro2 cycl,inhibit,HPV

1429192-00-6