ChemicalBook > CAS DataBase List > MK-8931

MK-8931

Product Name
MK-8931
CAS No.
1286770-55-5
Chemical Name
MK-8931
Synonyms
CS-2556;SCH900931;SCH-900931;SCH 900931;MK-8931-009;Verubecestat;MK-8931(Verubecestat);Verubecestat (MK-8931);Verubecestat free base;MK8931;MK 8931;MK-8931
CBNumber
CB22756736
Molecular Formula
C17H17F2N5O3S
Formula Weight
409.41
MOL File
1286770-55-5.mol
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MK-8931 Property

Melting point:
160-162oC
Density 
1.52±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
9.92±0.70(Predicted)
form 
Solid
color 
White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21115
Product name
Verubecestat
Purity
≥98%
Packaging
1mg
Price
$29
Updated
2024/03/01
Cayman Chemical
Product number
21115
Product name
Verubecestat
Purity
≥98%
Packaging
5mg
Price
$99
Updated
2024/03/01
Cayman Chemical
Product number
21115
Product name
Verubecestat
Purity
≥98%
Packaging
10mg
Price
$141
Updated
2024/03/01
Cayman Chemical
Product number
21115
Product name
Verubecestat
Purity
≥98%
Packaging
25mg
Price
$246
Updated
2024/03/01
TRC
Product number
V128850
Product name
Verubecestat
Packaging
25mg
Price
$235
Updated
2021/12/16
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MK-8931 Chemical Properties,Usage,Production

Uses

Verubecestat is used in a β-site amyloid precursor protein cleaving enzyme I inhibitor of treatment of alzheimer’s disease.

Biological Activity

ki: 2.2 and 3.4 nm for human and mouse bace1, respectivelyverubecestat (mk-8931) is a bace1 inhibitor.β-amyloid (aβ) peptides are regarded to be involved in the etiology of ad. bace1 is required for the aβ production, and bace1 inhibition is therefore an promising target for the ad treatment.

in vitro

verubecestat has been identified as a potent inhibitor of both human and mouse bace1 and verubecestat could also inhibit the production of ab40, ab42, and sappb in human cells with similar potency. verubecestat was also found to be a potent inhibitor of purified human bace2. moreover, verubecestat was essentially inactive with over 45,000-fold selectivity in the purified human aspartyl proteases cathepsin d, cathepsin e, and pepsin and had a very weak inhibitor of purified human renin with 15,000-fold selectivity. in addition, verubecestat was also found to have minimal or no activity against various tested receptors, ion channels, transporters, as well as enzymes [1].

in vivo

verubecestat could reduce plasma, cerebrospinal fluid, and brain concentrations of aβ40, aβ42, and sappβ after acute and chronic administration to both rats and monkeys. moreover, the chronic treatment of rats and monkeys with verubecestat at exposures >40-fold higher than those tested in

storage

Store at -20°C

References

[1] kennedy me et al. the bace1 inhibitor verubecestat (mk-8931) reduces cns β-amyloid in animal models and in alzheimer's disease patients. sci transl med.2016 nov 2;8(363):363ra150.

MK-8931 Preparation Products And Raw materials

Raw materials

Preparation Products

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MK-8931 Suppliers

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View Lastest Price from MK-8931 manufacturers

Career Henan Chemical Co
Product
MK-8931 1286770-55-5
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200KG
Release date
2019-07-01

1286770-55-5, MK-8931Related Search:

VESNARINONE Verteporfin

  • MK-8931; MK 8931; MK8931; MK-8931-009; SCH 900931; SCH-900931; SCH900931; VERUBECESTAT FREE BASE,
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  • Verubecestat (MK-8931)
  • (R)-N-(3-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoropicolinamide
  • MK-8931(Verubecestat)
  • MK8931;MK 8931;MK-8931
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  • orally,Beta-secretase,β-Secretase,inhibit,Aβ40,BACE1,MK8931,Alzheimer's,BACE,Inhibitor,MK 8931,Disease,BACE2,Verubecestat
  • 1286770-55-5