ChemicalBook > CAS DataBase List > (4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER

(4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER

Product Name: (4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER
CAS No.: 130721-78-7
Chemical Name: (4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER
Synonyms: tert-Butyl (4-chloropyridin-2-yl)carbamate;2-BOC-AMINO-4-CHLOROPYRIDINE;ert-Butyl(4-chloropyridin-2-yl)carbamate;tert-butyl N-(4-chloro-2-pyridyl)carbamate;tert-butyl N-(4-chloropyridin-2-yl)carbamate;(4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER;Carbamic acid, N-(4-chloro-2-pyridinyl)-, 1,1-dimethylethyl ester;(4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER ISO 9001：2015 REACH;tert-butyl 4-chloropyridin-2-ylcarbamate,(4-Chloro-pyridin-2-yl)-carbamic acid tert-butyl ester,tert-Butyl (4-chloropyridin-2-yl)carbamate,(4-Chloro-Pyridin-2-YL)-Carbamic Acid Tert-Butyl Ester,2-Boc-amino-4-chloropyridine
CBNumber: CB2278180
Molecular Formula: C10H13ClN2O2
Formula Weight: 228.68
MOL File: 130721-78-7.mol

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(4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER Property

Melting point:: (dec)
Boiling point:: 274℃
Density: 1.245
Flash point:: 120℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 11.89±0.70(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C10H13ClN2O2/c1-10(2,3)15-9(14)13-8-6-7(11)4-5-12-8/h4-6H,1-3H3,(H,12,13,14)
InChIKey: ATOQLEMIFREXLS-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NC1=NC=CC(Cl)=C1

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-43
Safety Statements: 36/37
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000275
Product name: (4-Chloro-pyridin-2-yl)-carbamic acid tert-butyl ester
Purity: Aldrich
Packaging: 1g
Price: $761
Updated: 2023/06/20

TRC

Product number: C381283
Product name: (4-Chloro-pyridin-2-yl)-carbamic acid tert-butyl ester
Packaging: 1g
Price: $95
Updated: 2021/12/16

TRC

Product number: C381283
Product name: (4-Chloro-pyridin-2-yl)-carbamic acid tert-butyl ester
Packaging: 5g
Price: $305
Updated: 2021/12/16

Matrix Scientific

Product number: 018229
Product name: (4-Chloro-pyridin-2-yl)-carbamic acidtert-butyl ester
Packaging: 1g
Price: $34
Updated: 2021/12/16

Matrix Scientific

Product number: 018229
Product name: (4-Chloro-pyridin-2-yl)-carbamic acidtert-butyl ester
Packaging: 5g
Price: $114
Updated: 2021/12/16

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(4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Uses

tert-Butyl (4-chloropyridin-2-yl)carbamate is used as an organic synthesis intermediate and a pharmaceutical intermediate for laboratory research and development processes and in the synthesis of pharmaceutical chemicals.

Synthesis

19798-80-2

24424-99-5

130721-78-7

LHMDS (1 M tetrahydrofuran solution, 17.11 mL, 17.11 mmol) was dissolved in tetrahydrofuran (5 mL) at -5 °C and tetrahydrofuran solution (5 mL) of 4-chloropyridin-2-amine (1 g, 7.78 mmol) was slowly added and stirred for 5 min. Subsequently, tetrahydrofuran solution (5 mL) of di-tert-butyl dicarbonate (Boc2O, 1.898 mL, 8.18 mmol) was added to the reaction mixture. The reaction system was maintained at 0°C and stirring was continued for 2 h. Upon completion of the reaction, the reaction was quenched by the addition of aqueous ammonium chloride solution. The pH of the reaction solution was adjusted to 6 with 1.5 N hydrochloric acid, followed by extraction with ethyl acetate (3 x 15 mL). The organic phases were combined and washed sequentially with sodium bicarbonate solution (15 mL), water (15 mL) and brine (15 mL). The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (gradient elution with ethyl acetate/petroleum ether) to afford the target product tert-butyl (4-chloropyridin-2-yl)carbamate (1.435 g, 6.28 mmol, 81% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 10.10 (s, 1H), 8.23 (d, J = 5.20 Hz, 1H), 7.88 (d, J = 2.00 Hz, 1H), 7.15 (dd, J = 2.00, 5.20 Hz, 1H), 1.48 (s, 9H).

References

[1] Angewandte Chemie - International Edition, 2015, vol. 54, # 20, p. 6037 - 6040
[2] Angew. Chem., 2015, vol. 127, # 20, p. 6135 - 6138,4
[3] Patent: WO2015/116060, 2015, A1. Location in patent: Page/Page column 97
[4] Patent: JP2015/528018, 2015, A. Location in patent: Paragraph 0198
[5] Patent: WO2011/139891, 2011, A1. Location in patent: Page/Page column 54

(4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER manufacturers

Dideu Industries Group Limited

Product: (4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER 130721-78-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-03

Career Henan Chemical Co

Product: (4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER 130721-78-7
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200kg
Release date: 2018-12-24

130721-78-7, (4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTERRelated Search:

(3-AMINO-6-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER (2-CHLORO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER (5-BROMO-6-CHLORO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER (6-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER TERT-BUTYL 4-CHLORO-3-HYDROXYPYRIDIN-2-YLCARBAMATE 2-(TERT-BUTOXYCARBONYLAMINO)-4-CHLORONICOTINIC ACID 2-(BOC-AMINO)-4,5-DICHLOROPYRIDINE 2-BOC-AMINO-4,6-DICHLOROPYRIDINE TERT-BUTYL 4-CHLORO-3-IODOPYRIDIN-2-YLCARBAMATE (4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER

(4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER

2-BOC-AMINO-4-CHLOROPYRIDINE

tert-Butyl (4-chloropyridin-2-yl)carbamate

tert-butyl N-(4-chloropyridin-2-yl)carbamate

tert-butyl N-(4-chloro-2-pyridyl)carbamate

Carbamic acid, N-(4-chloro-2-pyridinyl)-, 1,1-dimethylethyl ester

ert-Butyl(4-chloropyridin-2-yl)carbamate

(4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER ISO 9001：2015 REACH

tert-butyl 4-chloropyridin-2-ylcarbamate,(4-Chloro-pyridin-2-yl)-carbamic acid tert-butyl ester,tert-Butyl (4-chloropyridin-2-yl)carbamate,(4-Chloro-Pyridin-2-YL)-Carbamic Acid Tert-Butyl Ester,2-Boc-amino-4-chloropyridine

130721-78-7

pharmacetical