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PAROMOMYCIN SULFATE

Product Name
PAROMOMYCIN SULFATE
CAS No.
1263-89-4
Chemical Name
PAROMOMYCIN SULFATE
Synonyms
PAROMOMYCIN SULPHATE;sulf;humatin;NEOMYCIN E;PAROMOMYCIN SULFATE SALT;Neomycin Sulfate EP Impurity E;O - 2, 6 - Diamino - 2, 6 - dideoxy - b - L - idopyranosyl - (1,3) - O - b - D - ribofuranosyl - (1,5) - O - [2 - amino - 2 - deoxy - a - D - glucopyranosyl - (1,4) ] - 2 - deoxy - streptamine sulfate;fi5853;D00868;Humagel
CBNumber
CB2278832
Molecular Formula
C23H47N5O18S
Formula Weight
713.71
MOL File
1263-89-4.mol
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PAROMOMYCIN SULFATE Property

Melting point:
145 °C (decomp)
alpha 
D25 +50.5° (c = 1.5 in water pH 6)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
H2O: 50 mg/mL store stock solution at 2-8°C. Stable at 37°C for 5 days.
form 
powder
color 
White to Off-White
Water Solubility 
Soluble in water
Merck 
14,7041
BRN 
5715182
Stability:
Hygroscopic
InChIKey
LJRDOKAZOAKLDU-UDXJMMFXSA-N
CAS DataBase Reference
1263-89-4
EPA Substance Registry System
Paromomycin sulfate (1263-89-4)
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Safety

Hazard Codes 
Xi
Risk Statements 
23/24/25-36/38-39/23/24/25-61-36/37/38
Safety Statements 
26-36/37-45-38-36
WGK Germany 
2
RTECS 
WK2320000
HS Code 
2941901010
Toxicity
LD50 in mice (mg/kg): ~15,000 orally; 700 s.c.; 110 i.v. (Di Marco, Bertazzoli)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P5057
Product name
Paromomycin sulfate salt
Purity
powder, BioReagent, suitable for cell culture, ≥98%
Packaging
1g
Price
$55.6
Updated
2024/03/01
Sigma-Aldrich
Product number
512731
Product name
Paromomycin Sulfate - CAS 1263-89-4 - Calbiochem
Purity
An aminoglycoside antibiotic containing 5 amino groups that exhibits antibacterial and antiamebic activity.
Packaging
5G
Price
$148
Updated
2022/05/15
TCI Chemical
Product number
P2092
Product name
Paromomycin Sulfate
Purity
>94.0%(HPLC)
Packaging
1g
Price
$57
Updated
2024/03/01
TCI Chemical
Product number
P2092
Product name
Paromomycin Sulfate
Purity
>94.0%(HPLC)
Packaging
5g
Price
$170
Updated
2024/03/01
Alfa Aesar
Product number
J61274
Product name
Paromomycin sulfate
Packaging
1g
Price
$52.4
Updated
2024/03/01
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PAROMOMYCIN SULFATE Chemical Properties,Usage,Production

Description

Paromomycin was found in the culture broth of Streptomyces rimosus forma paromomycinus by Parke Davis & Co. in 1959. In the same year it was found in the culture broth of S. Crestomyceticus by Farmitalia and named amminosidin. Paromomycin is related structurally to neomycin, but it has a hydroxyl group at the 6 position, whereas neomycin has an amino group. Its antibacterial activity is weaker than that of neomycin, but its toxicity is much less. Paromomycin is used by intramuscular injection for therapy of respiratory, urinary, and surgical infections and by oral administration to treat dysentery and salmonellosis.

Chemical Properties

PAROMOMYCIN SULFATE is White to Off-White Solid

Uses

PAROMOMYCIN SULFATE is an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed addit ive in turkey poults experimentally infected with Histomonas meleagridis.

Uses

antibacterial, antiamebic

Uses

polymeric nonionic detergent

Definition

ChEBI: An aminoglycoside sulfate salt resulting from the treatment of paromomycin with sulfuric acid. A broad-spectrum antibiotic, it is used for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoa infections. It is also used as a therapeutic against visceral leishmaniasis.

brand name

Humatin (King); Humatin (Parke- Davis).

General Description

Chemical structure: aminoglycoside

Biochem/physiol Actions

Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

Clinical Use

The isolation of paromomycin (Humatin) was reported in1956 from a fermentation with a Streptomyces sp. (PD04998), a strain said to resemble S. rimosus very closely.The parent organism had been obtained from soil samplescollected in Colombia. Paromomycin, however, moreclosely resembles neomycin and streptomycin in antibioticactivity than it does oxytetracycline, the antibiotic obtainedfrom S. rimosus.
Paromomycin has broad-spectrum antibacterial activityand has been used for the treatment of GI infections causedby Salmonella and Shigella spp., and enteropathogenic E.coli. Currently, however, its use is restricted largely to thetreatment of intestinal amebiasis. Paromomycin is soluble inwater and stable to heat over a wide pH range.

Safety Profile

Poison by intravenous,subcutaneous, and intramuscular routes. Mildly toxic byingestion. Mutation data reported. When heated to decomposition it emits very toxic fumesof SOx and NOx.

Purification Methods

Purify it by dissolving it in H2O (0.5g/10mL) and adding excess EtOH, filter or collect and wash with EtOH, then Et2O by centrifugation, and dry it in vacuo. An aqueous solution is stable at 37o for a week but longer at 0-5o. The free base [7542-37-2] is a white amorphous powder which should be stored under N2 because it is strongly basic and can absorb CO2 from the atmosphere. It is soluble in MeOH (less soluble in EtOH) and has [] D 25 +65o (c 1.5, MeOH). It is an antimicrobial against Gram +ve and Gram –ve bacteria and is antiamoebic. It inhibits initiation and peptide elongation during protein synthesis. [Haskell et al. J Am Chem Soc 8 1 , 3480, 3482 1959, Hichens & Rinehart J Am Chem Soc 85 1547 1963, Beilstein 18 III/IV 7534.]

PAROMOMYCIN SULFATE Preparation Products And Raw materials

Raw materials

Preparation Products

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PAROMOMYCIN SULFATE Suppliers

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View Lastest Price from PAROMOMYCIN SULFATE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Paromomycin Sulfate 1263-89-4
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
≥675μg/mg; USP
Supply Ability
500kg
Release date
2021-08-19
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Paromomycin Sulfate 1263-89-4
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
50kg/Month
Release date
2024-09-04
Baoji Guokang Bio-Technology Co., Ltd.
Product
PAROMOMYCIN SULFATE 1263-89-4
Price
US $610.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1-10mt
Release date
2021-06-02

1263-89-4, PAROMOMYCIN SULFATERelated Search:

Nitazoxanide Spiramycin Rimonabant Ribostamycin sulfate SPECTINOMYCIN DIHYDROCHLORIDE (R)-2-Aminocyclohenanol Glucosamine sulfate PAROMOMYCIN SULFATE C-(TETRAHYDRO-PYRAN-2-YL)-METHYLAMINE HYDROCHLORIDE paromomycin 5-Deoxy-D-ribose Methyl beta-D-ribofuranoside TRANS-2-AMINOCYCLOHEXANOL HYDROCHLORIDE 3-BUTOXY-PROPIONALDEHYDE DIETHYL ACETAL 3-Amino-cyclohexanol {PAROMOMYCIN SULFATE--N/H PAROMOMYCIN SULFATE USP(CRM STANDARD) PAROMOMYCIN SULFATE WHO(CRM STANDARD)

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  • O - 2, 6 - Diamino - 2, 6 - dideoxy - b - L - idopyranosyl - (1,3) - O - b - D - ribofuranosyl - (1,5) - O - [2 - amino - 2 - deoxy - a - D - glucopyranosyl - (1,4) ] - 2 - deoxy - streptamine sulfate
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  • (2S,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-diamino-2-(((2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6-hydroxycyclohexyl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)tetrahydro-2H-pyran-3,4-diol sulfate(1:x)
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