3-(CYANOMETHYL)BENZOIC ACID
- Product Name
- 3-(CYANOMETHYL)BENZOIC ACID
- CAS No.
- 5689-33-8
- Chemical Name
- 3-(CYANOMETHYL)BENZOIC ACID
- Synonyms
- 25-50 g;Ketoprofen EP impurity 1;Ketoprofen EP Impurity H;m-(Cyanomethyl)benzoic acid;3-Carboxyphenylacetonitrile;3-(CYANOMETHYL)BENZOIC ACID;Benzoic acid, 3-(cyanomethyl)-;Ketoprofen Impurity 8(Ketoprofen EP Impurity H);3-(Cyanomethyl)benzoic acidQ: What is 3-(Cyanomethyl)benzoic acid Q: What is the CAS Number of 3-(Cyanomethyl)benzoic acid Q: What is the storage condition of 3-(Cyanomethyl)benzoic acid Q: What are the applications of 3-(Cyanomethyl)benzoic acid
- CBNumber
- CB2282116
- Molecular Formula
- C9H7NO2
- Formula Weight
- 161.16
- MOL File
- 5689-33-8.mol
3-(CYANOMETHYL)BENZOIC ACID Property
- Melting point:
- 175-176℃ (ethanol, 25% )
- Boiling point:
- 371.6±25.0 °C(Predicted)
- Density
- 1.257±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO, Methanol (Slightly)
- form
- Solid
- pka
- 4.04±0.10(Predicted)
- color
- White
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C981890
- Product name
- 3-(Cyanomethyl)benzoicAcid
- Packaging
- 250mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- C981890
- Product name
- 3-(Cyanomethyl)benzoicAcid
- Packaging
- 1g
- Price
- $215
- Updated
- 2021/12/16
- Product number
- C981890
- Product name
- 3-(Cyanomethyl)benzoicAcid
- Packaging
- 5g
- Price
- $520
- Updated
- 2021/12/16
- Product number
- FC67887
- Product name
- 3-(Cyanomethyl)benzoic acid
- Packaging
- 5G
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC67887
- Product name
- 3-(Cyanomethyl)benzoic acid
- Packaging
- 10g
- Price
- $125
- Updated
- 2021/12/16
3-(CYANOMETHYL)BENZOIC ACID Chemical Properties,Usage,Production
Uses
3-(Cyanomethyl)benzoic Acid (Ketoprofen EP Impurity H) is a reagent used in the synthesis of various pharmaceutically important compounds, such as its use in the synthesis of neprilysin inhibitors.
Uses
3-(Cyanomethyl)benzoic Acid is a reagent used in the synthesis of various pharmaceutically important compounds, such as its use in the synthesis of neprilysin inhibitors.
Synthesis
68432-92-8
5689-33-8
Lithium hydroxide (493 mg, 11.7 mmol) was added to a stirred mixed solution of methyl 3-(cyanomethyl)benzoate (1.029 g, 5.87 mmol) in THF (10 ml) and water (0.5 ml) at room temperature. The reaction mixture was stirred continuously at 50 °C overnight. After completion of the reaction, the solvent was removed by evaporation and the residue was partitioned between water and ether. The aqueous phase was extracted three times with ether. Subsequently, the aqueous phase was acidified to acidity with concentrated hydrochloric acid and again extracted three times with ether. All organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 745 mg (79% yield) of 3-cyanomethylbenzoic acid. The product was characterized by 1H NMR (DMSO-D6): δ 13.11 (1H, s), 7.95 (1H, s), 7.90 (1H, d, J = 7.6 Hz), 7.60 (1H, m), 7.53 (1H, t, J = 7.6 Hz), 4.14 (2H, s); MS (ESI) m/z 160 (M-1).
References
[1] Patent: WO2004/96781, 2004, A1. Location in patent: Page 80
3-(CYANOMETHYL)BENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-(CYANOMETHYL)BENZOIC ACID manufacturers
- Product
- 3-(CYANOMETHYL)BENZOIC ACID 5689-33-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-24